RecruitingNCT07738419

Diagnostic Accuracy of a Deep Learning-Based Software for Automated Multiparametric Echocardiographic Measurements

PANECHO: Diagnostic Accuracy of a Deep Learning-Based Artificial Intelligence Software Developed for Automated Multiparametric Echocardiographic Measurements From Echocardiographic Video Images: A Multicenter Study of the Italian Society of Echocardiography and Cardiovascular Imaging (SIECVI)


Sponsor

Centro Cardiologico Monzino

Enrollment

1,157 participants

Start Date

Apr 27, 2026

Study Type

OBSERVATIONAL

Conditions

Summary

Transthoracic echocardiography is an essential imaging modality for the diagnosis and follow-up of cardiovascular diseases. Comprehensive echocardiographic assessment requires multiple quantitative measurements of cardiac structure and function, which are time-consuming and highly dependent on operator expertise. US2.AI (Us2.v1) is an artificial intelligence (deep learning)-based software designed to automatically analyze standard two-dimensional and Doppler echocardiographic DICOM video clips acquired from different ultrasound vendors. The software provides automated measurements of cardiac morphology and function, including chamber dimensions and volumes, left and right ventricular systolic and diastolic function, myocardial strain, and Doppler-derived parameters, generating a comprehensive echocardiographic report based on current international guideline recommendations. In addition, the software may assist in identifying echocardiographic features suggestive of several cardiovascular conditions, including heart failure, pulmonary hypertension, hypertrophic cardiomyopathy, cardiac amyloidosis, valvular heart disease, and ischemic cardiomyopathy.


Eligibility

Min Age: 18 Years

Inclusion Criteria4

  • Adults aged 18 years or older.
  • Undergoing clinically indicated standard transthoracic echocardiography.
  • Adequate echocardiographic image quality for automated and expert analysis.
  • Written informed consent provided prior to study participation.

Exclusion Criteria3

  • Age <18 years.
  • Frequent and/or complex cardiac arrhythmias during echocardiographic examination.
  • Suboptimal echocardiographic images.

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Locations(1)

Centro Cardiologico Monzino, IRCCS

Milan, Lombardy, Italy

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NCT07738419


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