RecruitingNot ApplicableNCT07739992

Dose Optimization Study of Acute Intermittent Hypoxia in Spinal Cord Injury

Dose-Optimization Study of Acute Intermittent Hypoxia (DOSA-SCI): Effects on Lower-Limb Motor Function and Physiological Responsiveness in Individuals With Incomplete Spinal Cord Injury

Sponsor

Milap Sandhu

Enrollment

40 participants

Start Date

Jul 27, 2026

Study Type

INTERVENTIONAL

Conditions

Spinal Cord Injuries (SCI)

Summary

This study aims to evaluate how different doses of acute intermittent hypoxia (AIH) affect lower-limb strength, reaction time, and responsiveness in individuals with spinal cord injury (SCI). The objective is to identify the dose that most effectively improves motor output while also examining parameters that may account for variability in response.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Inclusion Criteria3

Chronic Spinal Cord Injury (>6 months)
Motor incomplete SCI classified as AIS C or D
Volitional ankle plantarflexion strength in at least one leg

Exclusion Criteria8

Uncontrolled hypertension (outside 140/90 and 90/60)
Concurrent medical illness
Traumatic brain injury
Cardiovascular complications
Pulmonary complications
Metabolic dysfunction
Continued use of anti-spasticity medications
Previously diagnosed obstructive sleep apnea

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Interventions

OTHERSham AIH

In this intervention, participants will wear a fitted mask, and will be given 15 bouts of room air through the same delivery system as the AIH interventions

OTHERAcute Intermittent Hypoxia (AIH) 15

In this intervention, participants will wear a fitted mask, and will be given 15, 60 second bouts of lowered oxygen (9% O2, akin to being on a tall mountain). Following the 60 seconds of hypoxia, participants will be given 60 seconds of room air

OTHERAcute Intermittent Hypoxia (AIH) 23

In this intervention, participants will wear a fitted mask, and will be given 23, 60 second bouts of lowered oxygen (9% O2, akin to being on a tall mountain). Following the 60 seconds of hypoxia, participants will be given 60 seconds of room air