RecruitingPhase 4NCT07746895

Real-World Effectiveness and Safety of Pegcetacoplan in Patients With C3G or IC-MPG: A Multi-Country Study

Real-World Effectiveness and Safety of Pegcetacoplan in Patients With C3 Glomerulopathy (C3G) or Primary Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN): A Multi-Country Study

Sponsor

Swedish Orphan Biovitrum

Enrollment

150 participants

Start Date

Aug 5, 2026

Study Type

INTERVENTIONAL

Conditions

C3 Glomerulopathy (C3G)Immune Complex Membranoproliferative Glomerulonephritis (IC-MPGN)

Summary

The purpose of this study is to evaluate the effectiveness and safety of Pegcetacoplan in patients with C3G and primary IC-MPGN in the real-world setting. This study will also assess biomarkers not routinely measured in clinical practice. Results will support the long-term evaluation of the benefit-risk profile of pegcetacoplan in a broad patient population, informing clinical decision-making.

Eligibility

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Pegcetacoplan for people with c3 glomerulopathy (c3g) and immune complex membranoproliferative glomerulonephritis (ic-mpgn). The study is currently recruiting participants at 101 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPegcetacoplan

Solution for infusion for subcutaneous use according to drug use in the real world.

Locations(101)

Nepean Hospital

Kingswood, Australia

Princess Alexandra Hospital

Woolloongabba, Australia

Medizinische Universität Graz

Graz, Austria

Uniklinik Innsbruck

Innsbruck, Austria

Allgemeines Krankenhaus Wien Universitätsklinik

Vienna, Austria

Klinik Ottakring

Vienna, Austria

Cliniques Universitaires Saint-Luc

Brussels, Belgium

University hosptial of Antwerpen

Edegem, Belgium

Grand Hôpital de Charleroi

Gilly, Belgium

UZ Leuven

Leuven, Belgium

Centre Hospitalier Universitaire de Liege

Liège, Belgium

CHU UCL Namur

Namur, Belgium

University of Calgary - Alberta Children's Hospital

Calgary, Alberta, Canada

British Columbia Childrens' & Women's Hospital Center

Vancouver, British Columbia, Canada

Kingston General Hospital

Kingston, Ontario, Canada

London Health Sciences Centre (LHSC) - Victoria Hospital

London, Ontario, Canada

The Hospital for Sick Children

Toronto, Ontario, Canada

University Health Network

Toronto, Ontario, Canada

McGill University

Montreal, Quebec, Canada

CHU Sainte-Justine

Montreal, Quebec, Canada

Institut klinicke a experimentalni mediciny

Prague, Czechia

Fakultni nemocnice v Motole

Prague, Czechia

CHU Bordeaux

Bordeaux, France

CHU Lyon - Hôpital Femme-Mère-Enfant

Bron, France

Hopital Henri Mondor

Créteil, France

Hopital Claude Huriez - CHU Lille

Lille, France

Hopital de la Conception - APHM

Marseille, France

Hopital Lapeyronie pt

Montpellier, France

CHU Nantes - Hôtel Dieu

Nantes, France

Hôpital Saint-Louis

Paris, France

AP-HP Georges-Pompidou European Hospital (Paris)

Paris, France

Hôpital Necker - Enfants Malades

Paris, France

Hôpital Robert Debré - Paris

Paris, France

Tenon CHU Paris Est

Paris, France

CHU Reims - Hôpital Maison Blanche

Reims, France

CHU Strasbourg - Nouvel Hôpital Civil

Strasbourg, France

Hôpital Foch

Suresnes, France

Universitaetsklinikum Aachen AOeR

Aachen, Germany

Charité - Campus Virchow-Klinikum

Berlin, Germany

University Hospital Cologne

Cologne, Germany

Universitaetsklinikum Carl Gustav Carus TU Dresden

Dresden, Germany

Universitaetsklinikum Erlangen

Erlangen, Germany

Universitaetsklinikum Essen

Essen, Germany

Universitaetsklinikum Essen

Essen, Germany

Universitaetsklinikum Hamburg-Eppendorf

Hamburg, Germany

Medizinische Hochschule Hannover

Hanover, Germany

Universitaetsklinikum Heidelberg

Heidelberg, Germany

Universitaetsklinikum Leipzig AoeR

Leipzig, Germany

Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz

Mainz, Germany

Universitaetsklinikum Regensburg

Regensburg, Germany

Robert-Bosch-Krankenhaus

Stuttgart, Germany

Nephrologisches Zentrum Villingen-Schwenningen

Villingen-Schwenningen, Germany

Nierenzentrum Wiesbaden

Wiesbaden, Germany

Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari

Bari, Italy

Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS

Bologna, Italy

Azienda Ospedaliero Universitaria di Bologna Policlinico S Orsola Malpighi

Bologna, Italy

Ospedali Riuniti di Foggia

Foggia, Italy

Azienda Ospedaliera Universitaria Gaetano Martino

Messina, Italy

Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico

Milan, Italy

Ospedale Pediatrico Bambino Gesù

Roma, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Roma, Italy

Azienda Ospedaliero-Universitaria Santa Maria della Misericordia

Udine, Italy

King Faisal Specialist Hospital & Research Center

Jeddah, Saudi Arabia

King Faisal Specialist Hospital & Research Center

Riyadh, Saudi Arabia

King Fahad Medical City

Riyadh, Saudi Arabia

Keimyung University Dongsan Hospital

Daegu, South Korea

Chungnam National University Hospital

Daejeon, South Korea

Seoul National University Bundang Hospital

Seongnam, South Korea

Seoul National University Hospital

Seoul, South Korea

Severance Hospital, Yonsei University Health System

Seoul, South Korea

Samsung Medical Center

Seoul, South Korea

The Catholic University of Korea, Seoul St. Mary's Hospital

Seoul, South Korea

Seoul Metropolitan Government Seoul National University Boramae Medical Center

Seoul, South Korea

Complejo Hospitalario Universitario A Coruña

A Coruña, Spain

Hospital Universitari Vall d'Hebron - VHIR

Barcelona, Spain

Hospital Clinic de Barcelona

Barcelona, Spain

Hospital Sant Joan de Deu

Barcelona, Spain

Hospital Universitario de la Palma

Las Palmas, Spain

Hospital General Universitario Gregorio Marañon

Madrid, Spain

Hospital Universitario 12 de Octubre

Madrid, Spain

Hospital La Paz

Madrid, Spain

Hospital Regional Universitario de Malaga

Málaga, Spain

Hospital Doctor Peset Valencia

Valencia, Spain

Hospital Universitari i Politecnic La Fe

Valencia, Spain

University of Basel

Basel, Switzerland

Inselspital - University Hospital Bern

Bern, Switzerland

Hôpitaux Universitaires de Genève - HUG

Geneva, Switzerland

CHUV, Lausanne University Hospital

Lausanne, Switzerland

University Hospital Zurich - Children's Hospital Zurich

Zurich, Switzerland

University Hospital Zurich

Zurich, Switzerland

Taipei Veterans General Hospital

Taipei, Taiwan

Cambridge University Hospitals NHS Foundation Trust

Cambridge, United Kingdom

University Hospital of Wales

Cardiff, United Kingdom

Royal Hospital for Children

Glasgow, United Kingdom

Leicester General Hospital

Leicester, United Kingdom

Royal Free Hospital

London, United Kingdom

Evelina London Children's Hospital

London, United Kingdom

Imperial College Healthcare NHS Trust (ICH)

London, United Kingdom

Royal Manchester Children's Hospital

Manchester, United Kingdom

Newcastle Hospital NHS Foundation Trust

Newcastle, United Kingdom

Salford Care Organisation

Salford, United Kingdom

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NCT07746895

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