Non-invasive Prediction of EArly Cardiac rEjection
Predictive Modeling of Acute Rejection in Pediatric Heart Transplant Recipients
Vanderbilt University Medical Center
200 participants
Mar 29, 2023
OBSERVATIONAL
Conditions
Summary
Acute rejection remains a major cause of morbidity and mortality in pediatric patients after heart transplant. In order to screen for rejection, most centers perform heart catheterizations with endomyocardial biopsies frequently in the first year post transplant and then every 1-2 years thereafter; these biopsies are associated with complications, can cause significant anxiety in patients and family members, and are a significant cost for the healthcare system. This project will evaluate non-invasive methods of detecting rejection using cardiac magnetic resonance imaging and blood testing with a goal to reduce the required number of cardiac catheterizations.
Eligibility
Plain Language Summary
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Locations(22)
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NCT07770659