RecruitingPhase 3NCT07771465

A Study of the Long-term Safety and Efficacy of Danicamtiv in Adults With Symptomatic Genetic and Familial Dilated Cardiomyopathy

An Open-label Extension Study to Assess the Long-term Safety and Efficacy of Danicamtiv in Adults With Symptomatic Genetic and Familial Dilated Cardiomyopathy

Sponsor

Kardigan, Inc.

Enrollment

332 participants

Start Date

Aug 26, 2026

Study Type

INTERVENTIONAL

Conditions

Symptomatic Genetic Dilated Cardiomyopathy (DCM)

Summary

Danicamtiv is an investigational medication, which means it is still being studied and has not been approved. The purpose of this study is to learn how well danicamtiv works, how safe it is, how well people can take it when used in patients with genetic or familial dilated cardiomyopathy (DCM). There are currently no approved medicines made specifically to treat genetic or familial DCM.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Danicamtiv for people with symptomatic genetic dilated cardiomyopathy (dcm). The study is currently recruiting participants at 78 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDanicamtiv

Danicamtiv will be administered twice daily for up to 5 years

Locations(78)

University of Alabama Birmingham

Birmingham, Alabama, United States

Cedars Sinai

Los Angeles, California, United States

University of California, Los Angeles (UCLA) - David Geffen School of Medicine

Los Angeles, California, United States

University of California, San Diego (UCSD) - Medical Center

San Diego, California, United States

University of California, San Francisco (UCSF)

San Francisco, California, United States

Stanford University Medical Center

Stanford, California, United States

MedStar Washington Hospital Center

Washington D.C., District of Columbia, United States

Mayo Clinic - Jacksonville

Jacksonville, Florida, United States

Northwestern University

Chicago, Illinois, United States

Louisiana State University (LSU) Health Sciences Center

New Orleans, Louisiana, United States

Johns Hopkins Medicine

Baltimore, Maryland, United States

Brigham and Women's Hospital

Boston, Massachusetts, United States

Henry Ford Health System

Detroit, Michigan, United States

University of Minnesota

Minneapolis, Minnesota, United States

Mayo Clinic - Rochester

Rochester, Minnesota, United States

Saint Luke's Mid America Heart Institute

Kansas City, Missouri, United States

Washington University in St. Louis

St Louis, Missouri, United States

University of Nebraska Medical Center

Omaha, Nebraska, United States

NYU Langone Health

New York, New York, United States

Columbia University Medical Center/ New York Presbyterian Hospital

New York, New York, United States

Duke University Medical Center

Durham, North Carolina, United States

The Lindner Center for Research and Education at The Christ Hospital

Cincinnati, Ohio, United States

The Ohio State University Wexner Medical Center

Columbus, Ohio, United States

Oregon Health & Science University (OHSU)

Portland, Oregon, United States

University of Pennsylvania

Philadelphia, Pennsylvania, United States

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Baylor College of Medicine

Houston, Texas, United States

Houston Methodist Hospital

Houston, Texas, United States

AZORG - Campus Moorselbaan

Aalst, Belgium

Universite Libre de Bruxelles (ULB) - Hopital Erasme

Brussels, Belgium

Universitair Ziekenhuis Antwerpen (UZA)

Edegem, Belgium

Jessa Ziekenhuis

Hasselt, Belgium

UZ Leuven

Leuven, Belgium

Aarhus University Hospital

Aarhus, Denmark

Rigshospitalet

Copenhagen, Denmark

Odense University Hospital - Odense

Odense, Denmark

CHRU de Tours - Hopital Trousseau

Chambray-lès-Tours, France

CHU de Lille - Institut Coeur Poumon

Lille, France

AP-HP Hopital Pitie-Salpetriere

Paris, France

AP-HP Hopital Europeen Georges Pompidou

Paris, France

CHU Rennes - Hopital Pontchaillou

Rennes, France

Semmelweis Egyetem - Varosmajori Sziv es Ergyogyaszati Klinika

Budapest, Hungary

Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont

Szeged, Hungary

Azienda Ospedaliera Universitaria Consorziale - Policlinico Bari

Bari, Italy

Azienda Ospedaliero-Universitaria Careggi

Florence, Italy

IRCCS Ospedale San Raffaele

Milan, Italy

Centro Cardiologico Monzino

Milan, Italy

ASST Grande Ospedale Metropolitano Niguarda

Milan, Italy

Azienda Ospedale - Università Padova

Padova, Italy

Fondazione IRCCS Policlinico San Matteo

Pavia, Italy

Ospedale Policlinico Casilino

Roma, Italy

Istituto Clinico Humanitas

Rozzano, Italy

Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI) - Ospedale di Cattinara

Trieste, Italy

Amsterdam UMC - Locatie AMC

Amsterdam, Netherlands

Maastricht University Medical Center

Maastricht, Netherlands

Erasmus MC

Rotterdam, Netherlands

Uniwersyteckie Centrum Kliniczne, Gdansk

Gdansk, Poland

Krakowski Szpital Specjalistyczny im. sw. Jana Pawla II

Krakow, Poland

Samodzielny Publiczny Zaklad Opieki Zdrowotnej Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi

Lodz, Poland

Narodowy Instytut Kardiologii Stefana kardynala Wyszynskiego - Panstwowy Instytut Badawczy w Warszawie

Warsaw, Poland

Hospital Universitario de A Coruña

A Coruña, Spain

Hospital Universitario Vall d'Hebron, Horta-Guinardó

Barcelona, Spain

Hospital Universitari de Bellvitge

Barcelona, Spain

Hospital Universitario Puerta de Hierro, Majadahonda, Madrid 20222

Madrid, Spain

Hospital Universitario Virgen de la Victoria

Málaga, Spain

Hospital Clinico Universitario Virgen de la Arrixaca

Murcia, Spain

Hospital Universitario Son Llatzer, Palma De Mallorca,

Palma de Mallorca, Spain

Hospital Universitario Virgen del Rocio

Seville, Spain

Sodersjukhuset AB

Stockholm, Sweden

Danderyds sjukhus

Stockholm, Sweden

University Hospitals Bristol NHS Foundation Trust

Bristol, United Kingdom

NHS Greater Glasgow and Clyde

Glasgow, United Kingdom

Glenfield hospital

Leicester, United Kingdom

St. Bartholomew's Hospital

London, United Kingdom

St George's Hospital

London, United Kingdom

Royal Brompton Hospital

London, United Kingdom

Hammersmith Hospital, Imperial College of London

London, United Kingdom

Cardiovascular Clinical Research Facility (CCRF)

Oxford, United Kingdom

View Full Details on ClinicalTrials.gov

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NCT07771465