RecruitingPhase 2NCT07787273

Interferon Gamma Plus Camrelizumab as Neoadjuvant Therapy for Locally Advanced Esophageal Squamous Cell Carcinoma

Study of Efficacy and Safety of Interferon Gamma Combined With Camrelizumab for Neoadjuvant Therapy in Patients With Locally Advanced Esophageal Squamous Cell Carcinoma


Sponsor

Hefei Cancer Hospital of the Chinese Academy of Sciences

Enrollment

84 participants

Start Date

Mar 20, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to evaluate the efficacy and safety of interferon-gamma combined with camrelizumab plus chemotherapy as neoadjuvant therapy for locally advanced esophageal squamous cell carcinoma. Based on previous mechanistic research and preliminary clinical data, this trial intends to generate high-level evidence for this therapeutic strategy, which may improve the treatment landscape for patients with locally advanced esophageal squamous cell carcinoma.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Camrelizumab and a drug called Interferon-γ for people with camrelizumab, locally advanced esophageal squamous cell carcinoma, and other related conditions. The study is currently recruiting participants at 2 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGInterferon-γ

1,000,000 IU administered intravenously on Day 1 of each 3-week cycle for a total of 3-4 cycles.

DRUGCamrelizumab

200 mg administered intravenously on Day 1 of each 3-week cycle for a total of 3-4 cycles.


Locations(2)

Hefei Cancer Hospital, Chinese Academy of Sciences

Hefei, Anhui, China

The First Affiliated Hospital of Anhui Medical University

Hefei, Anhui, China

View Full Details on ClinicalTrials.gov

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NCT07787273


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