RecruitingPhase 2NCT07791043

A Study to Investigate the Safety and Efficacy of Efimosfermin Alfa Compared With Placebo in Adult Participants With Alcohol-related Liver Disease (ALD)

A Dose-finding, Double-blind, Randomized, Placebo-controlled Phase 2 Study to Evaluate the Efficacy and Safety of Treatment With Efimosfermin Alfa in Adult Participants With Alcohol-related Liver Disease (ALD)


Sponsor

GlaxoSmithKline

Enrollment

274 participants

Start Date

Aug 31, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This is a dose-ranging study to evaluate safety of efimosfermin alfa and to establish proof-of-concept that efimosfermin alfa therapy provides benefit in participants with ALD.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Efimosfermin alfa and a drug called Placebo for people with liver diseases, alcoholic. The study is currently recruiting participants at 3 locations. People eligible for this study include aged 18 Years to 75 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGEfimosfermin alfa

Efimosfermin alfa will be administered.

DRUGPlacebo

Placebo will be administered.


Locations(3)

GSK Investigational Site

Topeka, Kansas, United States

GSK Investigational Site

Fort Worth, Texas, United States

GSK Investigational Site

San Antonio, Texas, United States

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NCT07791043


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