RecruitingNot ApplicableNCT07810166

Incremental Dead Space Versus Capping Trial Before Tracheostomy Decannulation

Incremental Dead Space Versus Capping Trial to Predict the Post-Decannulation Respiratory Status in Tracheostomized Critically Ill Patients: A Physiological Randomized Crossover Study


Sponsor

Pontificia Universidad Catolica de Chile

Enrollment

22 participants

Start Date

Aug 17, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

Some critically ill patients need a breathing tube placed directly into the windpipe (tracheostomy) because they require long-term help from a breathing machine. Before this tube can be safely removed (decannulation), medical team need to confirm the patient is ready to breathe on their own through the nose and mouth again. The most common way to check this is a "capping trial," in which the tube is blocked so air must pass through the upper airway, similar to normal breathing. However, because the tube itself remains in place during this test, it narrows the airway and may make breathing harder than it would be if the tube were actually removed. This could cause some patients to fail the test even though they are truly ready for the tube to come out, leading to unnecessary delays. This study will compare the standard capping trial with a new approach that instead adds extra tubing (dead space) to the breathing circuit, without blocking the airway, to more closely copy the breathing effort patients will experience once the tube is removed. Each participant will undergo both methods, in random order, during a single study day, with breathing effort, muscle activity, and comfort measured during each method and again after the tube is actually removed. The goal is to determine which method more accurately predicts how a patient will actually breathe once the tracheostomy tube is taken out.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Capping Trial and Incremental Instrumental Dead Space for people with prolonged mechanical ventilation, tracheostomy, and other related conditions. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERIncremental Instrumental Dead Space

Instrumental dead space applied through a modular low-resistance circuit connected to the tracheostomy for 45 minutes, intended to reproduce the respiratory demand associated with restoration of the upper airway after decannulation.

OTHERCapping Trial

The tracheostomy cuff is deflated and the tube is completely occluded with a standard cap, requiring the participant to breathe through the upper airway for 45 minutes unless predefined intolerance or safety criteria require earlier discontinuation.


Locations(1)

Hospital Clínico UC CHRISTUS, Unidad de Paciente Crítico

Santiago, Santiago Metropolitan, Chile

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NCT07810166


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