RecruitingNCT07814079

Targeted Ablation to Isolate Scar Channels Causing Ventricular Tachycardia

Segmental Substrate Isolation for the Treatment of Ventricular Tachycardia in Patients With Structural Heart Disease

Sponsor

New York Medical College

Enrollment

30 participants

Start Date

Mar 27, 2025

Study Type

OBSERVATIONAL

Conditions

Ischemic Cardiomyopathy Nonischemic Cardiomyopathy Ventricular Tachycardia (VT)

Summary

The goal of this study is to map conducting channels within scar that cause ventricular tachycardia (VT) in patients with scar in their hearts in order to block these channels from causing VT with targeted radiofrequency ablation (cautery). Participants undergoing VT ablation mapping of these channels by pacing many sites within the scar area and determining where these channels exit the scar into normal tissue. These exits will be ablated. Immediate success and success at 1 year will be evaluated.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a procedure called Selective Substrate Isolation for people with ischemic cardiomyopathy, nonischemic cardiomyopathy, and other related conditions. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURESelective Substrate Isolation

Ablation will be guided by mapping the substrate "from the inside out" by identifying conducting channels as they might be activated during VT. Extensive pace mapping will be performed within scar areas identified during sinus rhythm mapping. The course of these channels will be identified and ablated across the distal portion, just proximal to the exit based on shortest stimulus-to-QRS interval obtained.