Phase 1 ache Clinical Trials
16 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–16 of 16 trials
Recruiting
Phase 1
A Clinical Study of Nanocrystalline Megestrol Acetate in Concurrent Chemoradiotherapy for Locally Advanced Cervical Cancer
CachexiaLocally Advanced Cervical Cancer
Second Xiangya Hospital of Central South University88 enrolled1 locationNCT07338487
Recruiting
Phase 1
Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1
Post-Traumatic Headache
Yale University12 enrolled1 locationNCT06069791
Recruiting
Phase 1
A Dose Escalation Study of AV-380 in Cancer Patients With Cachexia
Cachexia
AVEO Pharmaceuticals, Inc.30 enrolled12 locationsNCT05865535
Recruiting
Phase 1
Orbit Study: A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Intrathecally Administered ION356 in Participants With Pelizaeus Merzbacher Disease (PMD)
Pelizaeus-Merzbacher Disease
Ionis Pharmaceuticals, Inc.24 enrolled7 locationsNCT06150716
Recruiting
Phase 1
A Phase I Clinical Study Evaluating the Safety, Tolerability, Pharmacokinetic Characteristics, and Preliminary Efficacy of SXRN Injection in Patients With Cancer Cachexia
Solid Tumor MalignanciesCachexia-Anorexia Syndrome
Jiangsu Nutai Biologics Co., Ltd54 enrolled1 locationNCT07231120
Recruiting
Phase 1Phase 2
VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma
Esophageal CancerPancreatic CancerHead and Neck Squamous Cell Carcinoma (HNSCC)+22 more
VM Oncology, LLC242 enrolled15 locationsNCT03556228
Recruiting
Phase 1
Cryospray Therapy for Benign Airway Stenosis
Stenosis Trachea
Virginia Commonwealth University12 enrolled1 locationNCT06085209
Recruiting
Phase 1
To Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of GB18 Injection in Healthy Participants
Cancer cachexia syndromeCancer CachexiaCancer Cachexia (CC)
Shenzhen Kexing Pharmaceutical Co., Ltd.36 enrolled1 locationNCT07237464
Recruiting
Phase 1
Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches
Mild Traumatic Brain InjuryHeadacheBrain Concussion+1 more
State University of New York - Upstate Medical University60 enrolled1 locationNCT06112093
Recruiting
Phase 1Phase 2
Treating Chronic Cervicogenic Head and Neck Pain
Cervicogenic headacheNeck Pain, Posterior
Michigan State University30 enrolled1 locationNCT05617365
Recruiting
Phase 1
UCB Transplant of Inherited Metabolic Diseases With Administration of Intrathecal UCB Derived Oligodendrocyte-Like Cells
Batten DiseaseAdrenoleukodystrophyPelizaeus-Merzbacher Disease+9 more
Joanne Kurtzberg, MD40 enrolled1 locationNCT02254863
Recruiting
Phase 1
A Phase I Study to Evaluate GFS202A in Advanced Solid Tumor Patients With Pre-cachexia or Cachexia
Cancer Cachexia
Genfleet Therapeutics (Shanghai) Inc.36 enrolled1 locationNCT06898255
Recruiting
Phase 1
A Study of JMT203 in Patients With Cancer Cachexia
Colorectal, CancerPancreatic CancerNon-small Cell Lung Cancer+1 more
Shanghai JMT-Bio Inc.130 enrolled1 locationNCT06868849
Withdrawn
Phase 1
Comparative assessment of the absorption of a generic formulation of a combination N-(4-hydroxyphenyl)acetamide/(RS)-2-(4-(2-Methylpropyl)phenyl)propanoic acid oral suspension against two innovator formulations administered simultaneously of N-(4-hydroxyphenyl)acetamide oral suspension and (RS)-2-(4-(2-Methylpropyl)phenyl)propanoic acid oral suspension conducted under fasting conditions in healthy volunteers.
(RS)-2-(4-(2-Methylpropyl)phenyl)propanoic acid is a nonsteroidal anti-inflammatory drug used for the temporary relief of fever, pain associated with teething, toothache, earache, sore throat, headache, minor ache, sprain, strain, cold and flu.N-(4-hydroxyphenyl)acetamide is an effective analgesic and antipyretic. It is indicated for the temporary relief of pain, discomfort associated with teething, headache, earache, immunisation, toothache, cold and flu, and it reduces fever.
Zenith Technology Corporation Limited24 enrolled1 locationACTRN12621001446853
Recruiting
Phase 1
Propofol on Trial for Headaches in the Emergency Department Setting
Refractory Headache
Dr Erik Wood30 enrolled2 locationsACTRN12617000345381
Completed
Phase 1
A study of aerosol Amikacin and Fosfomycin delivered via a new nebulizer system in mechanically ventilated patients.
Ventilator Associated Tracheobronchitis (VAT)
Cardeas Pharma9 enrolled1 locationACTRN12612000273886