ACL reconstruction Clinical Trials

10 recruitingLast updated: June 23, 2026

There are 10 actively recruiting acl reconstruction clinical trials across 7 countries. Studies span Not Applicable, Phase 2. Top locations include Houston, Texas, United States, Berlin, Germany, Bologna, Italy. Updated daily from ClinicalTrials.gov.


ACL reconstruction Trials at a Glance

10 actively recruiting trials for acl reconstruction are listed on ClinicalTrialsFinder across 6 cities in 7 countries. The largest study group is Not Applicable with 8 trials, with the heaviest enrollment activity in Houston, Berlin, and Bologna. Lead sponsors running acl reconstruction studies include Charite University, Berlin, Germany, Egas Moniz - Cooperativa de Ensino Superior, CRL, and Berivan Beril Kılıç.

Browse acl reconstruction trials by phase

Treatments under study

About ACL reconstruction Clinical Trials

Looking for clinical trials for ACL reconstruction? There are currently 14 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new ACL reconstruction trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about ACL reconstruction clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 110 of 10 trials

Recruiting

Clinical and Biomechanical Outcomes of Anterior Cruciate Ligament (ACL) Reconstruction Associated With Lateral Extra-articular Tenodesis (LET)

ACL reconstructionACL InjuriesTenodesis
Stefano Zaffagnini51 enrolled1 locationNCT07049484
Recruiting
Phase 2

Comparison of Functional Outcomes Following Arthroscopic ACL Reconstruction With Peroneus Longus Autograft With and Without Intra-articular Platelet-Rich Plasma Injection.

ACL reconstructionPRPIntraarticular Injection
Lahore General Hospital60 enrolled1 locationNCT07470359
Recruiting
Not Applicable

Effect of Internal Brace on Outcomes Following ACL Reconstruction With BTB Autograft

ACL reconstruction
NYU Langone Health90 enrolled1 locationNCT06542705
Recruiting
Not Applicable

Personalized Digital Training Intervention to Reduce Inflammation by Correcting Pathological Movement Patterns in Pre-stage Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction

ACL reconstructionOsteoarthritis(OA) of the knee
Charite University, Berlin, Germany60 enrolled2 locationsNCT06596824
Recruiting
Not Applicable

Efficacy of Focused Extracorporeal Shock Wave Therapy After Anterior Cruciate Ligament Reconstruction

ACL reconstructionExtracorpereal Shock Wave Therapy
Berivan Beril Kılıç32 enrolled1 locationNCT06688344
Recruiting
Not Applicable

Kinesiophobia vs. Task-Specific Fear: Defining Movement-Related Fear in ACL Reconstruction Patients

ACL reconstruction
Egas Moniz - Cooperativa de Ensino Superior, CRL21 enrolled2 locationsNCT07190456
Recruiting
Not Applicable

A Comparison of Outcomes After Anterior Cruciate Ligament (ACL) or Anterior Cruciate Ligament and Meniscus (ACL+Meniscus) Surgery Using Semiconductor Fabric Products

Anterior cruciate ligament ruptureACL reconstructionMeniscus Tears
Illinois Center for Orthopaedic Research and Education135 enrolled1 locationNCT06979804
Recruiting
Not Applicable

Protein Supplementation After ACL Surgery

ACL reconstruction
The Methodist Hospital Research Institute102 enrolled1 locationNCT06311058
Recruiting
Not Applicable

Effect of the Hockey Slideboard Training Combined With Blood Flow Restriction (BFR) in the Rehabilitation Following Anterior Cruciate Ligament Surgical Reconstruction (ACL-R)

Anterior cruciate ligament ruptureRehabilitation After ACL Reconstruction
Spitalul Municipal Odorheiu Secuiesc30 enrolled1 locationNCT06955026
Recruiting
Not Applicable

Does Blood Flow Restriction Training Improve Quadriceps Function After Arthroscopic Knee Surgery?

ACL reconstructionQuadriceps Atrophy
The University of Texas Health Science Center, Houston150 enrolled1 locationNCT03096366