Phase 1 Acute Myeloid Leukaemia Clinical Trials
12 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–12 of 12 trials
Recruiting
Phase 1Phase 2
Study of Lisaftoclax (APG-2575) Single Agent and Combination With Therapy in Patients Relapsed/Refractory AML
Myeloid MalignancyRelapsed/Refractory Acute Myeloid Leukaemia
Ascentage Pharma Group Inc.682 enrolled12 locationsNCT04501120
Recruiting
Phase 1Phase 2
Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression
Acute Lymphoblastic LeukaemiaAcute Myeloid Leukaemia
AstraZeneca84 enrolled30 locationsNCT07155226
Recruiting
Phase 1
Optimised CD33 (FL-33) CAR T Therapy for Refractory/Relapsed Acute Myeloid Leukaemia
Refractory/Relapsed Acute Myeloid Leukaemia
Beijing GoBroad Hospital27 enrolled4 locationsNCT06326021
Recruiting
Phase 1Phase 2
A Multi-Site Break Through Cancer Trial: Targeting Measurable Residual Disease in Patients With Acute Myeloid Leukemia: A Phase 1/2 Study of Tagraxofusp, Azacitidine, and Venetoclax
LeukemiaBlood CancersBlood Cancer+1 more
Jacqueline Garcia, MD31 enrolled2 locationsNCT07148180
Recruiting
Phase 1
Effect of Moderate Renal Impairment and Race/Ethnicity on Treosulfan Pharmacokinetics
Myelodysplastic Syndrome (MDS)Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)Acute Myeloid Leukaemia (AML)
medac GmbH36 enrolled4 locationsNCT05534620
Recruiting
Phase 1Phase 2
Clinical Study of U32 in Patients With Acute Myeloid Leukemia
Acute Myeloid Leukaemia
Shanghai Unicar-Therapy Bio-medicine Technology Co.,Ltd20 enrolled1 locationNCT07036250
Terminated
Phase 1
A clinical trial to assess the safety, distribution, effects on certain immune cells and anti-leukaemia effects of LAVA-1266 in patients with acute myeloid leukaemia or certain types of myelodysplastic syndrome
Refractory/Relapsed (R/R) acute myeloid leukaemia (AML)High risk myelodysplastic syndrome (MDS)Extremely high risk myelodysplastic syndrome (MDS)+1 more
LAVA Therapeutics N.V.50 enrolled4 locationsACTRN12624001214527
Recruiting
Phase 1
An Exploratory Randomized, Double-Blind, Placebo-Controlled, First-in-Human Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Ascending Doses of ZE63-0302 in Healthy Volunteers
Acute Myeloid Leukaemia (AML)
Eilean Therapeutics AU Pty Ltd (A subsidiary of Eilean Therapeutics LLC)88 enrolled1 locationACTRN12624000180516
Active
Phase 1
A phase Ib/II clinical evaluation of Ponatinib in combination with 5- Azacitidine in patients failing prior therapy for FLT3-ITD positive acute myeloid leukaemia (AMLM21)
Acute Myeloid Leukaemia (FLT3-ITD positive)
Australasian Leukaemia and Lymphoma Group42 enrolled8 locationsACTRN12614000810617
Terminated
Phase 1
Pilot Study of partially Human Leucocyte Antigen (HLA)-mismatched stem cell infusions after chemotherapy for acute myeloid leukaemia in patients over the age of 60.
Acute Myeloid Leukaemia > 60 yrs
St Vincent's Hospital, Sydney12 enrolled1 locationACTRN12613000337774
Completed
Phase 1
Lenalidomide with epigenetic therapy in relapsed or refractory Acute Myeloid Leukaemia (AML)-Phase I
Relapsed or refractory Acute Myeloid Leukaemia (AML)
Australasian Leukaemia and Lymphoma Group18 enrolled3 locationsACTRN12612000303842
Completed
Phase 1
High-dose lenalidomide maintenance therapy in adult acute myeloid leukaemia (AML)
Newly diagnosed acute myeloid leukaemia (except Acute promyelocytic leukaemia (APML))
Australasian Leukaemia and Lymphoma Group (ALLG)50 enrolled1 locationACTRN12610000627055