Phase 1 Advanced/Metastatic Clinical Trials
22 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 22 trials
Recruiting
Phase 1Phase 2
CR-001 in Adult Participants With Locally Advanced or Metastatic Solid Tumors
Locally Advanced/Metastatic Solid Tumors
Crescent Biopharma, Inc.290 enrolled17 locationsNCT07335497
Recruiting
Phase 1
A Study to Learn More About How Safe BAY 3771249 is and How Well it Works in People With Advanced or Metastatic Colorectal Cancer That Has a KRAS G12D Mutation
Advanced/Metastatic Colorectal Adenocarcinoma
Bayer130 enrolled21 locationsNCT07535112
Recruiting
Phase 1Phase 2
Dual-Target CAR-NK Cells Targeting MSLN, EGFR, or HER2 in Advanced NSCLC
Non-small Cell Lung CancerAdvanced/Metastatic
Beijing Biotech60 enrolled1 locationNCT07641023
Recruiting
Phase 1Phase 2
Symbiotic-GU-06: A Study to Learn About PF-08634404 Alone or In Combination With Enfortumab Vedotin in Urothelial Cancer
Urothelial CarcinomaUrothelial CancerAdvanced/Metastatic Urothelial Cancer
Pfizer132 enrolled50 locationsNCT07421700
Recruiting
Phase 1Phase 2
Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers
Non-small Cell Lung CancerCarcinoma, Non-Small Cell LungAdvanced/Metastatic Non-Small Cell Lung Cancer
Pfizer162 enrolled45 locationsNCT07227298
Recruiting
Phase 1
A Phase I Clinical Study of HLX316 in Participants With Advanced/Metastatic Solid Tumors
Advanced/Metastatic Solid Tumors
Shanghai Henlius Biotech41 enrolled5 locationsNCT07541534
Recruiting
Phase 1Phase 2
A Phase I/II of HRS-6719 in Patients With Advanced/Metastatic Solid Tumors
Advanced/Metastatic Solid Tumors
Shandong Suncadia Medicine Co., Ltd.120 enrolled2 locationsNCT06922357
Recruiting
Phase 1
A Phase I Study to Evaluate the Safety, Tolerability, and PK of HLX43 in Advanced/Metastatic Solid Tumors
Advanced/Metastatic Malignant Solid Tumors
Shanghai Henlius Biotech367 enrolled10 locationsNCT06115642
Recruiting
Phase 1
A Study of ATG-022 in Patients With Advanced/Metastatic Solid Tumors
Advanced/Metastatic Solid Tumors
Antengene Biologics Limited156 enrolled22 locationsNCT05718895
Recruiting
Phase 1
A Study of DB-1317 in Selected Advanced/Metastatic Solid Tumors
Advanced/Metastatic Solid Tumors
DualityBio Inc.233 enrolled6 locationsNCT07141706
Recruiting
Phase 1
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
Esophageal CancerPancreatic CancerUrothelial Carcinoma+10 more
Pfizer310 enrolled28 locationsNCT07090499
Recruiting
Phase 1Phase 2
Dual-Target CAR-NK Cells for Advanced Breast Cancer HER2+ TNBC
Triple-Negative Breast CancerHER2-positive Breast CancerBreast Cancer (Advanced/Metastatic)
Beijing Biotech60 enrolled1 locationNCT07510802
Recruiting
Phase 1Phase 2
Dual-Target CAR-NK Cells Directed Against MSLN, EGFR, or HER2 in Advanced NSCLC
Non-small Cell Lung CancerAdvanced/Metastatic NSCLC
Beijing Biotech48 enrolled1 locationNCT07467863
Recruiting
Phase 1Phase 2
Phase 1/II Clinical Study of SYS6043 in the Treatment of Advanced/Metastatic Solid Tumors
Advanced/Metastatic Solid Tumors
CSPC Megalith Biopharmaceutical Co.,Ltd.820 enrolled1 locationNCT07415863
Recruiting
Phase 1Phase 2
ADG126 in Combination With Pembrolizumab in Patients With Advanced/Metastatic Solid Tumors
Advanced/Metastatic Solid Tumors
Adagene Inc186 enrolled21 locationsNCT05405595
Recruiting
Phase 1
Study of ISM3412 in Participants With Locally Advanced/Metastatic Solid Tumors
Locally Advanced/Metastatic Solid Tumors
InSilico Medicine Hong Kong Limited80 enrolled9 locationsNCT06414460
Recruiting
Phase 1
Study of ESG406 in Adults With Solid Tumors
Locally Advanced/Metastatic Solid Tumors
Shanghai Escugen Biotechnology Co., Ltd556 enrolled3 locationsNCT06979674
Recruiting
Phase 1Phase 2
Study of MHB088C for Patients With Advanced Solid Malignant Tumors
Advanced/Metastatic Solid Tumors
Qilu Pharmaceutical Co., Ltd.515 enrolled1 locationNCT07102004
Recruiting
Phase 1
First in Human Study of EMB-07 in Locally Advanced/Metastatic Solid Tumors or Relapse/Refractory Lymphoma
Advanced/Metastatic Solid TumorsRelapse/Refractory Lymphoma
EpimAb Biotherapeutics (Suzhou)Co., Ltd.150 enrolled10 locationsNCT05607498
Recruiting
Phase 1Phase 2
First-line Trastuzumab, Gemcitabine, Cisplatin and Nivolumab in Advanced HER2- Positive Biliary Tract Cancer: a Multicenter, Open-label, Single-arm Phase Ib/II Trial (HERBOT)
HER2 Positive Advanced/Metastatic/Nonresectable Biliary Tract Cancer
Yonsei University44 enrolled1 locationNCT05749900