Phase 1 Advanced Non-Small Cell Lung Cancer Clinical Trials
22 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 22 trials
Recruiting
Phase 1Phase 2
First in Human Study of BAY2927088 in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Epidermal Growth Factor Receptor (EGFR) and/or Human Epidermal Growth Factor Receptor 2 (HER2)
HER2 MutationAdvanced Non-Small Cell Lung CancerEGFR Mutation
Bayer400 enrolled94 locationsNCT05099172
Recruiting
Phase 1
A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing
Locally Advanced Hepatocellular CarcinomaLocally Advanced MelanomaMetastatic Hepatocellular Carcinoma+7 more
National Cancer Institute (NCI)30 enrolled1 locationNCT06066138
Recruiting
Phase 1
A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors
Head and Neck CancerHNSCCColo-rectal Cancer+4 more
ALX Oncology Inc.170 enrolled8 locationsNCT07085091
Recruiting
Phase 1Phase 2
A 2-part Phase 1/2 Open-label Trial on ODM-212
Pancreatic CancerMesotheliomaNSCLC (Advanced Non-small Cell Lung Cancer)
Orion Corporation, Orion Pharma229 enrolled2 locationsNCT07563738
Recruiting
Phase 1Phase 2
A Study of BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations
NSCLC (Advanced Non-small Cell Lung Cancer)
BlossomHill Therapeutics266 enrolled41 locationsNCT06706076
Recruiting
Phase 1Phase 2
A Trial of Injectable SHR-A1811 in Combination With Pyrotinib or SHR-1316 in Subjects With Advanced Non-small Cell Lung Cancer
Advanced Non-Small Cell Lung Cancer
Jiangsu HengRui Medicine Co., Ltd.324 enrolled2 locationsNCT05482568
Recruiting
Phase 1
Study of Aerosolized Antibiotics and Pembrolizumab in Advanced Non-small Cell Lung Cancer
Advanced Non-Small Cell Lung Cancer
National Cancer Institute (NCI)23 enrolled1 locationNCT05777603
Recruiting
Phase 1
A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
Esophageal CancerPancreatic CancerUrothelial Carcinoma+10 more
Pfizer310 enrolled28 locationsNCT07090499
Recruiting
Phase 1Phase 2
NBTXR3 With Radiation Therapy Alone for Locally-advanced Non-small Cell Lung Cancer
Locally Advanced Non-Small Cell Lung Cancer
M.D. Anderson Cancer Center40 enrolled1 locationNCT07224152
Recruiting
Phase 1
Evaluation of JSKN016 Combination Therapy in Subjects With NSCLC
Advanced Non-Small Cell Lung Cancer
Jiangsu Alphamab Biopharmaceuticals Co., Ltd288 enrolled1 locationNCT06868732
Recruiting
Phase 1Phase 2
An Phase Ib/II Clinical Trial of TCC1727 Combination Therapy in Advanced Solid Tumors
Endometrial CancerGastric (Stomach) CancerNSCLC (Advanced Non-small Cell Lung Cancer)+2 more
Beijing Tide Pharmaceutical Co., Ltd266 enrolled3 locationsNCT07371663
Recruiting
Phase 1
A Phase l Clinical Study to Evalute the Safety,Tolerability,Pharmacokinetic Characteristics,and Preliminary Anti-tumor Efficacy of HJ-004-02 Tablets in Patients With Non-squamous Non-small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Mutations
NSCLC (Advanced Non-small Cell Lung Cancer)
Tongji University36 enrolled1 locationNCT07361237
Recruiting
Phase 1
Ladarixin With Sotorasib in Advanced NSCLC
Advanced Non-small Cell Lung Cancer With KRAS G12C Mutation
NYU Langone Health40 enrolled6 locationsNCT05815173
Recruiting
Phase 1
Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors
Endometrial CancerMetastatic Solid TumorSolid Tumor, Adult+4 more
Sairopa B.V.130 enrolled7 locationsNCT05856981
Recruiting
Phase 1
A Study of CEA-Targeted CAR-T Therapy in Patients With CEA-Positive Advanced Solid Tumors
Breast CancerNSCLC (Advanced Non-small Cell Lung Cancer)
Second Affiliated Hospital, School of Medicine, Zhejiang University48 enrolled1 locationNCT07250386
Recruiting
Phase 1Phase 2
A Study to Assess the Efficacy and Safety of WSD0922-FU in Patients With EGFRm+ Advanced Non-small Cell Lung Cancer
EGFR Mutation Positive Advanced Non-Small Cell Lung Cancer
Wayshine Biopharm, Inc.100 enrolled12 locationsNCT06631989
Recruiting
Phase 1
A Phase Ib Study of JMKX001899 in Combination With Other Therapies in Advanced NSCLC Harboring KRAS G12C Mutation
NSCLC (Advanced Non-small Cell Lung Cancer)
Jemincare72 enrolled1 locationNCT06946927
Recruiting
Phase 1
A Study on the Efficacy and Safety of Golidocitinib Combined With Tislelizumab and Chemotherapy as First-line Treatment for Advanced NSCLC
NSCLC (Advanced Non-small Cell Lung Cancer)
Peking University Cancer Hospital & Institute21 enrolled1 locationNCT06969612
Recruiting
Phase 1Phase 2
A Phase 1/2 Study to Evaluate the Safety, Tolerability and PK of JIN-A02 in Patients With EGFR Mutant Advanced NSCLC
EGFR Mutant Advanced Non-small Cell Lung Cancer
J Ints Bio150 enrolled10 locationsNCT05394831
Recruiting
Phase 1Phase 2
Cisplatin (CIS) Administered As Dry Powder for Inhalation (DPI) in Patients with Stage IV Non-Small Cell Lung Cancer
NSCLC (Advanced Non-small Cell Lung Cancer)Stage IV Lung Cancer
Inhatarget Therapeutics32 enrolled15 locationsNCT06896890