Adverse childhood experience Clinical Trials

10 recruitingLast updated: May 13, 2026

There are 10 actively recruiting adverse childhood experience clinical trials across 2 countries. Studies span Not Applicable, Early Phase 1. Top locations include Iowa City, Iowa, United States, Durham, North Carolina, United States, Irvine, California, United States. Updated daily from ClinicalTrials.gov.


Adverse childhood experience Trials at a Glance

10 actively recruiting trials for adverse childhood experience are listed on ClinicalTrialsFinder across 6 cities in 2 countries. The largest study group is Not Applicable with 7 trials, with the heaviest enrollment activity in Iowa City, Durham, and Irvine. Lead sponsors running adverse childhood experience studies include Nathaniel Jenkins, Loma Linda University, and Duke University.

Browse adverse childhood experience trials by phase

Treatments under study

About Adverse childhood experience Clinical Trials

Looking for clinical trials for Adverse childhood experience? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Adverse childhood experience trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Adverse childhood experience clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 110 of 10 trials

Recruiting
Not Applicable

Evaluating an Adverse Childhood Experience-Targeting Advocate Model of a Substance Use Prevention Program

Substance-Related DisordersAdverse Childhood Experiences
RTI International360 enrolled1 locationNCT06236100
Recruiting
Early Phase 1

Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking

Nicotine Dependence, CigarettesAdverse Childhood Experiences
Duke University150 enrolled1 locationNCT05665465
Recruiting
Not Applicable

The THRIVE Study: Teaching Healthy Regulation in Individuals & Vulnerable Environments

Adverse Childhood ExperiencesFamily Functioning
University of California, Irvine210 enrolled1 locationNCT06821035
Recruiting
Not Applicable

Early Life Exposures Among Children With Sickle Cell Disease

Sickle Cell DiseaseBreastfeedingAdverse Childhood Experiences
University of Alabama at Birmingham20 enrolled1 locationNCT05377372
Recruiting
Not Applicable

The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies

SleepSleep DisturbanceEndothelial Dysfunction+6 more
Nathaniel Jenkins70 enrolled1 locationNCT06454344
Recruiting
Not Applicable

Probing the Role of Mitochondrial Oxidative Stress in Impaired Vascular Function Among Young Adults With Early Life Adversity

Adverse childhood experienceEndothelial Function (FMD)Mitochondrial Function+3 more
University of Iowa300 enrolled1 locationNCT07244809
Recruiting
Not Applicable

Building Resilient Families

Adverse Childhood Experiences
Loma Linda University340 enrolled1 locationNCT05388864
Recruiting

School Violence Exposure as an Adverse Childhood Experience

Adverse Childhood ExperiencesMental Health OutcomesPerceived School Safety+1 more
Teachers College, Columbia University2,500 enrolled1 locationNCT06153316
Recruiting
Not Applicable

ACEs, SIRT1, and Premature Vascular Aging in Humans

Endothelial DysfunctionAdverse Childhood Experiences
Nathaniel Jenkins30 enrolled1 locationNCT07073352
Recruiting

Chinese Community Sample of Hierarchical Model of Psychopathology

Adverse childhood experienceMental Health Issue
Shanghai Mental Health Center4,000 enrolled1 locationNCT06105970