Phase 1 ALT Clinical Trials
557 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 557 trials
Recruiting
Phase 1
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
HealthyMild Cognitive ImpairmentAlzheimer s Disease
National Institute of Mental Health (NIMH)90 enrolled1 locationNCT07169630
Recruiting
Phase 1
Developing Biomarkers of Dietary Intake: Dose Dependent Measurement of Sugar Intake
Healthy VolunteersDiet Therapy
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)60 enrolled1 locationNCT04799301
Recruiting
Phase 1
A Study to Understand What the Body Does to the Study Medicine Called PF-07799544 When Taken by Healthy Adults
Healthy male volunteers
Pfizer9 enrolled1 locationNCT07578636
Recruiting
Phase 1
Evaluation of [11C]ZTP-1 to Image PDE4B
Healthy
National Institute of Mental Health (NIMH)40 enrolled1 locationNCT07625345
Recruiting
Phase 1
Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)
High Grade GliomaLow-grade GliomaRecurrent World Health Organization (WHO) Grade II Glioma
University of California, San Francisco50 enrolled17 locationsNCT04485559
Recruiting
Phase 1Phase 2
A Phase 1/2 Study of PRO-203 in Healthy Volunteers and Participants With Systemic Sclerosis.
Healthy VolunteersSclerodermaSystemic Sclerosis (SSc)+1 more
Prolium Bioscience, Inc44 enrolled3 locationsNCT07641634
Recruiting
Phase 1
Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ICP-538 in Healthy Subjects
Health Services Research
Beijing InnoCare Pharma Tech Co., Ltd.104 enrolled1 locationNCT07535099
Recruiting
Phase 1Phase 2
Behavioral Economic Attributes of Recreation
Cardiometabolic Health Indicators
Rush University Medical Center120 enrolled1 locationNCT07282418
Recruiting
Phase 1
A Bioequivalence Study Between Two Casdatifan Tablet Strengths and Food Effect Study of Casdatifan in Healthy Adult Participants
Healthy Participants
Arcus Biosciences, Inc.24 enrolled1 locationNCT07641881
Recruiting
Phase 1Phase 2
Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms
Healthy VolunteersAlcohol Use Disorder (AUD)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)180 enrolled1 locationNCT06484075
Recruiting
Phase 1
A Study to Investigate the Effect of the CYP3A Inducer Phenytoin and the CYP3A Inhibitor Itraconazole on the Pharmacokinetics of BGB-58067 in Healthy Participants
Healthy Volunteers
BeOne Medicines30 enrolled1 locationNCT07590102
Recruiting
Phase 1
Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers
Healthy
National Institute of Mental Health (NIMH)40 enrolled1 locationNCT06874205
Recruiting
Phase 1
A Study of LY3971297 in Healthy Participants
ObesityHypertensionHealthy
Eli Lilly and Company225 enrolled7 locationsNCT06148272
Recruiting
Phase 1
A Study in People With Overweight or Obesity to Compare How 2 Different Formulations of Survodutide Are Taken up by the Body
ObesityHealthyOverweight
Boehringer Ingelheim80 enrolled1 locationNCT07407348
Recruiting
Phase 1
A Study of the Effects of Itraconazole on LY4395089 in Healthy Participants
Healthy
Eli Lilly and Company14 enrolled1 locationNCT07592572
Recruiting
Phase 1
Evaluate the Effect of Vimseltinib on Pharmacokinetics of Combined Oral Contraceptive (Ethinyl Estradiol/Levonorgestrel)
Healthy Participants
Deciphera Pharmaceuticals, LLC24 enrolled1 locationNCT07539090
Recruiting
Phase 1Phase 2
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Healthy VolunteersAnemia, Sickle Cell
Bristol-Myers Squibb184 enrolled34 locationsNCT06481306
Recruiting
Phase 1
LH-001 vs Placebo in Healthy Participants
Healthy
Chien-Liang Lin56 enrolled1 locationNCT06546449
Recruiting
Phase 1
A Study to Evaluate How the Study Drug Moves Through the Body, Adverse Events, and How the Body Tolerates ABBV-547 Injections
Healthy Volunteer
AbbVie121 enrolled23 locationsNCT07232004
Recruiting
Phase 1
A Study of LY4065967 in Healthy Participants
Healthy
Eli Lilly and Company36 enrolled2 locationsNCT07607483