Phase 1 ALT Clinical Trials
478 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 478 trials
Recruiting
Phase 1
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
HealthyMild Cognitive ImpairmentAlzheimer s Disease
National Institute of Mental Health (NIMH)90 enrolled1 locationNCT07169630
Recruiting
Phase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4954 in Healthy Adult Participants With or Without Elevated Lipoprotein (a) (Lp[a]) Levels, and Participants With Dyslipidemia
Healthy ParticipantsDyslipidemia
AstraZeneca136 enrolled6 locationsNCT06980428
Recruiting
Phase 1
A Study to Learn About a Vaccine Against E Coli in Healthy Adults
Healthy Participants
Pfizer310 enrolled11 locationsNCT07122986
Recruiting
Phase 1
A Study to Test How BI 1291583 is Taken up in the Blood of People With and Without Liver Problems
HealthyHepatic Impairment
Boehringer Ingelheim32 enrolled3 locationsNCT07023354
Recruiting
Phase 1
A Study of SYNT-101 to Test Safety, Tolerability and Pharmacodynamics of SYNT-101 in Healthy and Overweight Adults
HealthyOverweight and Obese Adults
Syntis Bio64 enrolled1 locationNCT07307274
Recruiting
Phase 1
A Drug-Drug Interaction Study of Itraconazole and Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-017)
Healthy
Merck Sharp & Dohme LLC14 enrolled1 locationNCT07548606
Recruiting
Phase 1
A Phase 1 Study of BLKR201 in Healthy Adult Participants
Healthy
Formation Bio, Inc.128 enrolled1 locationNCT07501039
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics of GenSci161 in Healthy Adult Participants
Healthy Volunteers
Changchun GeneScience Pharmaceutical Co., Ltd.44 enrolled1 locationNCT07476586
Recruiting
Phase 1
A Study to Assess the Bioequivalence of Trastuzumab Via Different Subcutaneous Delivery Platforms in Healthy Male Participants
Healthy Participants
Genentech, Inc.312 enrolled4 locationsNCT07214766
Recruiting
Phase 1Phase 2
Study Evaluating ABCL635 for Vasomotor Symptoms of Menopause
Healthy VolunteersVasomotor Symptoms Associated With Menopause
AbCellera Biologics Inc.136 enrolled13 locationsNCT07118891
Recruiting
Phase 1
A First-in-Human Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Single and Multiple Oral Doses of Debio 1453P in Healthy Adults
Healthy Participants
Debiopharm International SA88 enrolled1 locationNCT07035769
Recruiting
Phase 1
The Primary Purpose of This Study is to Determine if Biotin, Vitamin B7 is an Effective Way to Label Platelets in Survival and Recovery Studies.
Healthy Volunteers
Bloodworks12 enrolled1 locationNCT07513532
Recruiting
Phase 1
Serial MR Imaging and MR Spectroscopic Imaging for the Characterization of Lower Grade Glioma
WHO Grade III GliomaWHO Grade II GliomaRecurrent WHO Grade III Glioma+1 more
Susan Chang300 enrolled1 locationNCT04540107
Recruiting
Phase 1
A Study in Healthy Men to Test How Well Different Doses of BI 3821001 Are Tolerated
Healthy
Boehringer Ingelheim72 enrolled1 locationNCT07526194
Recruiting
Phase 1
OMAR Opioid Use Disorder
Healthy Control
Yale University30 enrolled1 locationNCT05683184
Recruiting
Phase 1
Assessment of 11C-JMJ-129 for Imaging PDE4D in Brain and Whole Body of Healthy Volunteers
Healthy
National Institute of Mental Health (NIMH)40 enrolled1 locationNCT06874205
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability, PK/PD of HEC-007 Injection in Healthy and Overweight/Obese Subjects
Healthy Subjects
Sunshine Lake Pharma Co., Ltd.126 enrolled1 locationNCT07102251
Recruiting
Phase 1Phase 2
Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms
Healthy VolunteersAlcohol Use Disorder (AUD)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)180 enrolled1 locationNCT06484075
Recruiting
Phase 1Phase 2
A Study to Learn About the Treatment LTP001 in Healthy Participants (Part A) and in Participants With PAH (Part B)
Healthy Volunteers, Pulmonary Arterial Hypertension
Novartis Pharmaceuticals232 enrolled85 locationsNCT06649110
Recruiting
Phase 1
A Study to Investigate Safety, Tolerability, and Pharmacokinetics of AZD3974 in Healthy Participants
Healthy Participants
AstraZeneca176 enrolled2 locationsNCT07290283