Phase 1 Amyloidosis Clinical Trials
17 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–17 of 17 trials
Recruiting
Phase 1
Study of GC012F, CAR-T Therapy Targeting CD19 and BCMA in Chinese Participants With Relapsed or Refractory AL Amyloidosis
Relapsed/Refractory AL Amyloidosis
Gracell Biotechnologies (Shanghai) Co., Ltd.9 enrolled9 locationsNCT07250269
Recruiting
Phase 1Phase 2
A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis)
Relapsed/Refractory Systemic Light Chain Amyloidosis
Regeneron Pharmaceuticals220 enrolled19 locationsNCT06292780
Recruiting
Phase 1
A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis
Relapsed or Refractory Multiple MyelomaPreviously Treated Amyloid Light-chain (AL) Amyloidosis
Janssen Research & Development, LLC180 enrolled29 locationsNCT05652335
Recruiting
Phase 1
Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or Refractory Light Chain Amyloidosis
Refractory AL AmyloidosisRecurrent AL Amyloidosis
National Cancer Institute (NCI)24 enrolled16 locationsNCT04847453
Recruiting
Phase 1
Repeat PET/CT Imaging in People With CAPS and Anakinra-Induced Amyloidosis Using an Amyloid-Reactive Peptide to Measure Changes in Organ-Specific Amyloid Load
AmyloidosisCryopyrin-Associated Periodic Syndromes
National Institute of Allergy and Infectious Diseases (NIAID)30 enrolled1 locationNCT06974877
Recruiting
Phase 1
Test-retest Study With [18F]FBB in Cardiac Amyloidosis
Cardiac Amyloidosis
Life Molecular Imaging GmbH15 enrolled2 locationsNCT06790394
Recruiting
Phase 1Phase 2
A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.
AmyloidosisLight Chain AmyloidosisRelapsed AL Amyloidosis+1 more
Alexion Pharmaceuticals, Inc.91 enrolled18 locationsNCT07081646
Recruiting
Phase 1Phase 2
Elranatamab in Patients With Relapsed or Refractory AL Amyloidosis
AL Amyloidosis
Brigham and Women's Hospital49 enrolled1 locationNCT06569147
Recruiting
Phase 1Phase 2
Phase 1/2a Study of Belantamab Mafodotin in Relapsed or Refractory AL Amyloidosis
AmyloidosisAL Amyloidosis
University of Texas Southwestern Medical Center37 enrolled3 locationsNCT05145816
Recruiting
Phase 1Phase 2
Assessment of the Efficacy and Safety of Injectable TQB2934 (Subcutaneous Injection) in Systemic Light Chain Amyloidosis Patients
Systemic Light Chain Amyloidosis
Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.70 enrolled23 locationsNCT07266116
Recruiting
Phase 1Phase 2
A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Immunoglobulin Light Chain (AL) Amyloidosis Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion
Immunoglobulin Light Chain (AL) Amyloidosis
AbbVie76 enrolled21 locationsNCT06158854
Recruiting
Phase 1Phase 2
Study of NXC-201 CAR-T in Patients With Light Chain (AL) Amyloidosis
Light Chain (AL) Amyloidosis
Nexcella Inc.40 enrolled18 locationsNCT06097832
Recruiting
Phase 1Phase 2
Venetoclax-Dexamethasone in Relapsed and/or Refractory t(11;14) Amyloidosis
AL Amyloidosis
Rajshekhar Chakraborty, MD53 enrolled4 locationsNCT05451771
Recruiting
Phase 1Phase 2
A Phase I/IIa，Open-label, Single Ascending Dose and Dose-expansion Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of YOLT-201 in Patients With Transthyretin Amyloidosis Polyneuropathy (ATTR-PN) or Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM)
Transthyretin Amyloidosis PolyneuropathyTransthyrexin Amyloidosis Cardiomyopathy
YolTech Therapeutics Co., Ltd31 enrolled3 locationsNCT06539208
Recruiting
Phase 1Phase 2
Haemodynamic Effects of Dobutamine in Patients With Wild-type Transthyretin Amyloid Cardiomyopathy (ATTRwt)
ATTR Amyloidosis Wild Type
Steen Hvitfeldt Poulsen35 enrolled1 locationNCT06318260
Recruiting
Phase 1
Study of AT-02 in Healthy Volunteers and Subjects With Systemic Amyloidosis
Amyloidosis; Systemic
Attralus, Inc.100 enrolled11 locationsNCT05521022
Recruiting
Phase 1
FKC288 for Relapsed or Refractory Systemic Light Chain (AL) Amyloidosis
Light Chain Amyloidosis
Nanjing University School of Medicine12 enrolled1 locationNCT05978661