Ankle instability Clinical Trials

14 recruitingLast updated: May 13, 2026

There are 14 actively recruiting ankle instability clinical trials across 11 countries. Studies span Not Applicable. Top locations include Ljubljana, Slovenia, Fort Bragg, North Carolina, United States, Greenfield, Indiana, United States. Updated daily from ClinicalTrials.gov.


Ankle instability Trials at a Glance

14 actively recruiting trials for ankle instability are listed on ClinicalTrialsFinder across 6 cities in 11 countries. The largest study group is Not Applicable with 7 trials, with the heaviest enrollment activity in Ljubljana, Fort Bragg, and Greenfield. Lead sponsors running ankle instability studies include University of Ljubljana, Hancock Orthopedics, and Chirurgie Du Sport.

Browse ankle instability trials by phase

Treatments under study

About Ankle instability Clinical Trials

Looking for clinical trials for Ankle instability? There are currently 4 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Ankle instability trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Ankle instability clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 114 of 14 trials

Recruiting

Effects of Ankle Evertor Fatigue on Force Sense and Neuromuscular Activation in Subjects With Chronic Ankle Instability

Chronic Ankle Instability, CAI
University of Ljubljana50 enrolled1 locationNCT07252219
Recruiting

Effects of Ankle Evertor Fatigue on Perturbed Gait

Chronic Ankle Instability, CAI
University of Ljubljana40 enrolled1 locationNCT07273097
Recruiting
Not Applicable

Neurocognitive Ankle Training for Instability to Optimize Neuromusculoskeletal Outcomes (NATION)

Chronic ankle instability
Womack Army Medical Center180 enrolled2 locationsNCT06527287
Recruiting
Not Applicable

Preop US-Guided Nerve Blocks for Pain & Recovery After Ankle Arthroscopy

Ankle Ligament Injury,Chronic Ankle Instability,Ankle Arthroscopy
Second Affiliated Hospital, School of Medicine, Zhejiang University70 enrolled1 locationNCT07470021
Recruiting
Not Applicable

BioBrace® in Arthroscopic Brostrom Lateral Ankle Ligament Repair

ATFLLateral Ankle InstabilityAnterior Talofibular Ligament+4 more
Hancock Orthopedics40 enrolled1 locationNCT07401095
Recruiting
Not Applicable

Acute Effect of Graded Motor Imagery on Ankle Rehabilitation: A Pilot Study

Ankle instabilityHealthy (Controls)
Istanbul University - Cerrahpasa48 enrolled1 locationNCT07376915
Recruiting

French Ankle Ligament Surgery Cohort Study

Ankle instabilityAnkle (Ligaments); Instability (Old Injury)Ankle Ligament Rupture+1 more
Chirurgie Du Sport5,000 enrolled1 locationNCT07188363
Recruiting
Not Applicable

Effect of Functional Core Stability Training or Cognitive Training on Balance and Postural Control in Chronic Ankle Instability

Chronic ankle instabilityPostural ControlBalance; Distorted+2 more
Cairo University45 enrolled1 locationNCT07283276
Recruiting
Not Applicable

Comparison of Resistance Training With and Without Plyometric Exercises on Athletes With Chronic Ankle Instability.

Chronic ankle instability
Riphah International University24 enrolled1 locationNCT06552533
Recruiting
Not Applicable

Role of Sensory Deficits on Sensorimotor Control in Athletes With Chronic Ankle Instability

Chronic ankle instability
National Yang Ming Chiao Tung University150 enrolled1 locationNCT06118879
Recruiting

SOFARI Clinical Outcomes Registry

Disorders of synovium or tendons of the ankle and footClaw and hammertoe deformitiesIngrowing nails+7 more
Sydney Orthopaedic Foot and Ankle Research Institute (SOFARI)50,000 enrolled1 locationACTRN12620000331932
Recruiting

Effects of Combining Mobilization of the Proximal Tibiofibular Joint and the Talocrural Joint in Subjects with Ankle Instability

Ankle instability
National Yang-Ming University60 enrolled1 locationACTRN12619001152112
Recruiting

Clinical trial comparing two surgical techniques used to treat instability of the ankle in those people who are normally involved in sports activities.

Chronic lateral ankle instability
Mark Porter42 enrolled1 locationACTRN12618000906257
Recruiting

Dry needling effects on muscle recruitment pattern and motor control in basketball players with functional ankle instability

Functional ankle instability
Universidad de Alcala28 enrolled1 locationACTRN12616000386437