Ankle sprain Clinical Trials

21 recruitingLast updated: May 21, 2026

There are 21 actively recruiting ankle sprain clinical trials across 14 countries. Studies span Not Applicable. Top locations include Beijing, China, São Paulo, São Paulo, Brazil, Lexington, Kentucky, United States. Updated daily from ClinicalTrials.gov.


Ankle sprain Trials at a Glance

21 actively recruiting trials for ankle sprain are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Not Applicable with 13 trials, with the heaviest enrollment activity in Beijing, São Paulo, and Lexington. Lead sponsors running ankle sprain studies include Peking University Third Hospital, Cairo University, and Centre Hospitalier Universitaire de Saint Etienne.

Browse ankle sprain trials by phase

About Ankle sprain Clinical Trials

Looking for clinical trials for Ankle sprain? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Ankle sprain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Ankle sprain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 21 trials

Recruiting
Not Applicable

Semiconductor Embedded Socks for Ankle Sprains

Ankle sprain
University of Colorado, Denver100 enrolled1 locationNCT07025733
Recruiting
Not Applicable

A Study on Reducing Opioid Use After Minimally Invasive Ankle Surgery

Opioid analgesiaAnkle sprainAnkle (Ligaments); Instability (Old Injury)+2 more
Second Affiliated Hospital, School of Medicine, Zhejiang University110 enrolled1 locationNCT07154433
Recruiting
Not Applicable

Investigating the Effects of Cognitive Functional Therapy on Pain, Physical Function, and Kinesiophobia in Individuals With Chronic Ankle Sprain

Chronic Ankle SprainChronic Ankle Sprains
Yeditepe University40 enrolled1 locationNCT07449078
Recruiting
Not Applicable

Addressing Neuromuscular Deficits for Improved Outcomes in Ankle Rehabilitation

ankle sprains
Phillip Gribble150 enrolled2 locationsNCT03663361
Recruiting
Not Applicable

Performance and Safety of LightForce® Therapy Lasers on Lateral Ankle Sprain

Acute PainAnkle Sprain 1St DegreeAnkle Sprain 2Nd Degree
DJO UK Ltd108 enrolled8 locationsNCT06854016
Recruiting
Not Applicable

NMES With PNF for Ankle Sprain Rehabilitation

Ankle sprain
Fooyin University60 enrolled1 locationNCT07190599
Recruiting
Not Applicable

Auditory Biofeedback Gait Training Individuals With Chronic Ankle Instability

ankle sprainsAnkle Injuries and Disorders
University of Kentucky100 enrolled2 locationsNCT06868316
Recruiting
Not Applicable

Surgical Management of Lateral Ankle Instability: Modified Broström-Gould Versus Arthroscopic Allograft Reconstruction of the Anterior Talofibular and Calcaneofibular Ligaments.

Ankle sprain
Universidad Francisco de Vitoria36 enrolled1 locationNCT07200271
Recruiting

The Clinical Outcomes of the Modified Broström vs Anatomic Reconstruction Operation in CLAI and GJL

ankle sprainsJoint HypermobilityInstability, Joint
Peking University Third Hospital100 enrolled1 locationNCT05196906
Recruiting

Comparison of MBR + Suture Tape and MBR for CLAI in GJL Cases: A Prospective Cohort Study

Ankle sprainHypermobility, Joint
Peking University Third Hospital86 enrolled1 locationNCT06897293
Recruiting

Comparison of MBR + Suture Tape, MBR, and Anatomic Reconstruction for CLAI in GJL Cases: A Prospective Cohort Study

ankle sprainsHypermobility Syndrome
Peking University Third Hospital114 enrolled1 locationNCT05698446
Recruiting
Not Applicable

Spinal and Supraspinal Control in Chronic Ankle Instability

Ankle injuriesankle sprains
Ayca Yagcioglu30 enrolled2 locationsNCT06898554
Recruiting

Computed Tomography with Stress Maneuvers for Evaluation of Distal Tibiofibular Syndesmosis Instability (CTMETS)

Ankle sprain
Hospital Israelita Albert Einstein133 enrolled1 locationNCT04095598
Recruiting

First-degree Ankle Sprains

Ankle Sprain 1St Degree
Rehabilitation Centre Zivot100 enrolled1 locationNCT06645262
Recruiting
Not Applicable

Effect of ACL Reconstruction in Biomechanical Properties of Ankle Joint Complex

ankle sprainsAnterior Cruciate Ligament tear
Cairo University40 enrolled1 locationNCT06631690
Recruiting
Not Applicable

Arthroscopic Versus Open Brostrom for Ankle Instability

ankle sprainsSurgeryLigament Injury+1 more
Federal University of São Paulo98 enrolled2 locationsNCT03643926
Recruiting
Not Applicable

A Mobile Recovery Guidance App for Children and Young Adults With Acute Ankle Inversion Injuries

ankle sprains
Naveen Poonai250 enrolled1 locationNCT05785533
Recruiting

Interest of Ultrasound in the Diagnosis of Severity of Lateral Ankle Sprain

ankle sprains
Centre Hospitalier Universitaire de Saint Etienne50 enrolled1 locationNCT04846712
Recruiting
Not Applicable

The Effect of Taping on Plantar Pressure Distribution in Players With Chronic Ankle Instability

Ankle injuriesankle sprainsAnkle Injuries and Disorders
Cairo University88 enrolled1 locationNCT06499935
Recruiting

Immediate effects of direct thrust manipulation of talus in the dorsiflexion range of movement, posterior talar glide and dynamic postural control.

Ankle sprain
Nuno Alexandre Fernandes Pinheiro40 enrolled1 locationACTRN12618001679279