Calcification Clinical Trials

40 recruitingLast updated: July 25, 2026

There are 40 actively recruiting calcification clinical trials across 27 countries. Studies span Not Applicable, Phase 4, Phase 2, Phase 1, Phase 3. Top locations include New York, New York, United States, Boston, Massachusetts, United States, Norfolk, Virginia, United States. Updated daily from ClinicalTrials.gov.


Calcification Trials at a Glance

40 actively recruiting trials for calcification are listed on ClinicalTrialsFinder across 6 cities in 27 countries. The largest study group is Not Applicable with 15 trials, with the heaviest enrollment activity in New York, Boston, and Norfolk. Lead sponsors running calcification studies include Luzerner Kantonsspital, Inozyme Pharma, and Abbott Medical Devices.

Browse calcification trials by phase

Treatments under study

About Calcification Clinical Trials

Looking for clinical trials for Calcification? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Calcification trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Calcification clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 40 trials

Recruiting

Diagnosis and Treatment of Patients With Inborn Errors of Metabolism

Arterial Calcification Due to Deficiency of CD73
National Human Genome Research Institute (NHGRI)4,000 enrolled1 locationNCT00369421
Recruiting

MitrAl Valve Calcium aSsEssmEnt With TrueVue Trans-illumination 3D Rendering.

Mitral Valve DiseaseMitral Annular Calcification
Centro Cardiologico Monzino100 enrolled1 locationNCT07612553
Recruiting
Not Applicable

Intravascular Lithotripsy With or Without Rotational Atherectomy for Coronary Calcified Nodule Treatment

Coronary Artery DiseaseCoronary Calcification
Annapoorna Kini120 enrolled1 locationNCT07000045
Recruiting
Not Applicable

Multicenter Cardiac Decision Impact Study in People With Breast Cancer

Breast CancerCardiovascular (CV) RiskCoronary Artery Calcifications
UMC Utrecht1,000 enrolled5 locationsNCT07703033
Recruiting

Mechanisms Of Disease Progression in Aortic Stenosis - the MODAS Study

GeneticsPathogenesisAortic Stenosis+3 more
Heinrich-Heine University, Duesseldorf938 enrolled3 locationsNCT05851209
Recruiting

Abbott Cephea Mitral Valve Disease Registry

Mitral RegurgitationMitral StenosisMitral Valve Disease+4 more
Abbott Medical Devices1,000 enrolled23 locationsNCT07069673
Recruiting

Use of Discarded Surgery Human Tissue Specimens for Basic Science Research

Vascular CalcificationOsteoblast
Centre Hospitalier Universitaire, Amiens200 enrolled1 locationNCT04753593
Recruiting
Not Applicable

The THOR IDE Study

Peripheral Artery DiseasePADPeripheral Artery Stenosis+1 more
Philips Clinical & Medical Affairs Global155 enrolled29 locationsNCT05916950
Recruiting

CHoice of OptImal transCatheter trEatment for Mitral Insufficiency Registry

Mitral RegurgitationMitral Valve DiseaseMitral Annular Calcification
Universitätsklinikum Hamburg-Eppendorf1,000 enrolled43 locationsNCT04688190
Recruiting
Not Applicable

Orbital Atherectomy vs Intravascular Lithotripsy for the Treatment of Calcified Coronary Nodules (ORBIT-SHOCK).

Chronic Coronary SyndromeCoronary Arterial Disease (CAD)Percutaneous Coronary Intervention (PCI)+6 more
Spanish Society of Cardiology50 enrolled6 locationsNCT06736665
Recruiting
Not Applicable

TECTONIC CAD IVL IDE Study

Coronary Artery DiseaseCoronary Artery CalcificationStenotic Coronary Lesion
Abbott Medical Devices335 enrolled41 locationsNCT06885177
Recruiting
Phase 1

The ENERGY Study: Evaluation of Safety and Tolerability of INZ-701 in Infants With ENPP1 Deficiency or ABCC6 Deficiency

Pseudoxanthoma ElasticumEctonucleotide Pyrophosphatase/phosphodiesterase1 DeficiencyAutosomal Recessive Hypophosphatemic Rickets+2 more
Inozyme Pharma16 enrolled7 locationsNCT05734196
Recruiting
Phase 3

ENERGY 2: Evaluation of the Efficacy and Safety of INZ-701 in Infants With ENPP1 Deficiency

Ectonucleotide Pyrophosphatase/phosphodiesterase1 DeficiencyAutosomal Recessive Hypophosphatemic RicketsGeneralized Arterial Calcification of Infancy 1
Inozyme Pharma12 enrolled8 locationsNCT07473973
Recruiting
Not Applicable

DCB vs DES for Severe Coronary Calcification After Optimal Modification Assessed by QFR

Coronary Calcification
Shanghai Zhongshan Hospital656 enrolled1 locationNCT07277114
Recruiting
Phase 2

Treatment of Ectopic Calcification in Fahr's Disease or Syndrome

Fahr DiseaseFahr SyndromePrimary Familial Brain Calcification
UMC Utrecht98 enrolled2 locationsNCT05662111
Recruiting
Not Applicable

Mammography and Breast Arterial Calcification: An Information-Sharing Trial

MammographyVascular Calcification
Icahn School of Medicine at Mount Sinai5,708 enrolled1 locationNCT04983875
Recruiting
Not Applicable

CAlcified Coronary Lesions Identification & Quantification With X Rays

Coronary Calcification
RCF@ICPS30 enrolled3 locationsNCT07417150
Recruiting

A Novel Ferumoxytol-enhanced Cardiac Magnetic Resonance for the Detection of Calcified Coronary Arteries

Coronary Artery Calcification
The First Affiliated Hospital with Nanjing Medical University100 enrolled1 locationNCT07400406
Recruiting
Not Applicable

The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).

Mitral RegurgitationMitral StenosisMitral Valve Disease+1 more
Mayra Guerrero210 enrolled17 locationsNCT04408430
Recruiting

CRUSH PAD: Real-world Outcomes Following Use of Shockwave Intravascular Lithotripsy (IVL) Technology in Calcified Common Femoral Lesions

ClaudicationPeripheral Arterial DiseaseFemoral Arterial Calcification+1 more
Yale University50 enrolled2 locationsNCT05145478