Phase 2 Carcinoma, Non-Small Cell Lung Clinical Trials
28 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 28 trials
Recruiting
Phase 1Phase 2
Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC)
Non-small Cell Lung Cancer (NSCLC)Non-small Cell Lung CancerCarcinoma, Non-Small Cell Lung+1 more
National Cancer Institute (NCI)60 enrolled1 locationNCT06694454
Recruiting
Phase 1Phase 2
KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)
Carcinoma, Non-Small Cell Lung
Merck Sharp & Dohme LLC450 enrolled46 locationsNCT04165070
Recruiting
Phase 2
A Study of Navlimetostat (BMS-986504) in Participants With Pre-treated Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With Homozygous MTAP Deletion (MountainTAP-9)
Carcinoma, Non-Small Cell Lung
Bristol-Myers Squibb130 enrolled70 locationsNCT06855771
Recruiting
Phase 1Phase 2
A Study of Amivantamab and Olomorasib Combination Therapy in Participants With Metastatic Non-Small Cell Lung Cancer
Carcinoma, Non-Small Cell Lung
Janssen Research & Development, LLC60 enrolled15 locationsNCT07227025
Recruiting
Phase 2
A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Carcinoma, Non-Small Cell Lung
Janssen Research & Development, LLC480 enrolled201 locationsNCT06667076
Recruiting
Phase 2
A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)
Carcinoma, Non-Small Cell Lung
Johnson & Johnson Enterprise Innovation Inc.130 enrolled41 locationsNCT06667908
Recruiting
Phase 2
A Study of Amivantamab in Participants With Advanced or Metastatic Solid Tumors Including Epidermal Growth Factor Receptor (EGFR)-Mutated Non-Small Cell Lung Cancer
Carcinoma, Non-Small Cell Lung
Janssen Research & Development, LLC520 enrolled110 locationsNCT05498428
Recruiting
Phase 1Phase 2
Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers
Non-small Cell Lung CancerCarcinoma, Non-Small Cell LungAdvanced/Metastatic Non-Small Cell Lung Cancer
Pfizer162 enrolled45 locationsNCT07227298
Recruiting
Phase 2
A Study of Investigational Agents in Participants With Previously Treated Stage IV Nonsquamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01H/KEYMAKER-U01)
Carcinoma, Non-Small Cell Lung
Merck Sharp & Dohme LLC96 enrolled32 locationsNCT06780085
Recruiting
Phase 1Phase 2
Intratumoral N17350 in Advanced Solid Tumors
MelanomaCarcinoma, Non-Small Cell LungHead and Neck Neoplasms+4 more
Onchilles Pharma Inc275 enrolled1 locationNCT07339176
Recruiting
Phase 1Phase 2
A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer
Carcinoma, Non-Small Cell LungSquamous Cell Carcinoma of Head and NeckOvarian Neoplasms+8 more
Cancer Research UK167 enrolled4 locationsNCT06380816
Recruiting
Phase 2
A Study of LP-300 With Carboplatin and Pemetrexed in Never Smokers With Advanced Lung Adenocarcinoma
Carcinoma, Non-Small Cell LungAdenocarcinoma of Lung
Lantern Pharma Inc.90 enrolled16 locationsNCT05456256
Recruiting
Phase 2
Preoperative Radioimmunotherapy Versus Chemoimmunotherapy in NSCLC
Carcinoma, Non-Small Cell Lung
Weill Medical College of Cornell University112 enrolled1 locationNCT06623656
Recruiting
Phase 2
THIO Sequenced With Cemiplimab in Advanced NSCLC
Carcinoma, Non-Small Cell Lung
Maia Biotechnology227 enrolled35 locationsNCT05208944
Recruiting
Phase 2
Enhanced Dermatological Care to Reduce Rash and Paronychia in Epidermal Growth Factor Receptor (EGRF)-Mutated Non-Small Cell Lung Cancer (NSCLC) Treated First-line With Amivantamab Plus Lazertinib
Carcinoma, Non-Small Cell Lung
Janssen Research & Development, LLC300 enrolled93 locationsNCT06120140
Recruiting
Phase 2
Intrathecal Pemetrexed for Leptomeningeal Metastasis in EGFR-Mutant NSCLC
Carcinoma, Non-Small Cell LungLeptomeningeal MetastasisEpidermal Growth Factor Receptor
Taipei Veterans General Hospital, Taiwan23 enrolled1 locationNCT05805631
Recruiting
Phase 2
Durvalumab and Tremelimumab in Combination With Chemotherapy in HIV-infected Patients With Non-small Cell Lung Cancer
Carcinoma, Non-Small Cell Lung
Georgetown University18 enrolled4 locationsNCT04499053
Recruiting
Phase 2
Immune Profile Selection By Fraction of ctDNA in Patients With Advanced NSCLC Treated With Immunotherapy
Carcinoma, Non-Small Cell Lung
Hackensack Meridian Health108 enrolled3 locationsNCT05715229
Recruiting
Phase 1Phase 2
Quaratusugene Ozeplasmid (Reqorsa) and Osimertinib in Patients With Advanced Lung Cancer Who Progressed on Osimertinib
Carcinoma, Non-Small Cell Lung
Genprex, Inc.158 enrolled10 locationsNCT04486833
Recruiting
Phase 2
Locally Advanced NSCLC Treated With Radiochemotherapy: Phase 2 Study on the Value of a Stereotactic Boost
Carcinoma, Non-Small Cell Lung
Centre Antoine Lacassagne42 enrolled1 locationNCT06627738