Phase 3 Central Nervous System Clinical Trials
16 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–16 of 16 trials
Recruiting
Phase 3
A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)
DementiaBrain DiseasesCentral Nervous System Diseases+6 more
Eli Lilly and Company1,500 enrolled141 locationsNCT05508789
Recruiting
Phase 3
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy
Mixed Phenotype Acute LeukemiaB Acute Lymphoblastic LeukemiaB Lymphoblastic Lymphoma+2 more
Children's Oncology Group5,951 enrolled230 locationsNCT03959085
Recruiting
Phase 3
IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)
Relapsed/Refractory Primary Central Nervous System Lymphoma
Ono Pharmaceutical Co., Ltd.132 enrolled4 locationsNCT07104032
Recruiting
Phase 3
A Study of a Gadolinium-Based Contrast Agent (GBCA) for Adults Undergoing Magnetic Resonance Imaging (MRI) for Known or Highly Suspected Central Nervous System (CNS) Lesions
For Contrast-enhanced Magnetic Resonance Imaging (MRI) of Central Nervous System (CNS) Lesions
Shanghai Shengdi Pharmaceutical Co., Ltd250 enrolled2 locationsNCT07275814
Recruiting
Phase 3
A Study of a Gadolinium-Based Contrast Agent (GBCA) for Adults Undergoing Magnetic Resonance Imaging (MRI) for Known or Highly Suspected Body Parts (Non-Central Nervous System) Lesions
For Contrast-enhanced Magnetic Resonance Imaging (MRI) of Abnormal Vascular Lesions in Body Regions Excluding the Central Nervous System (CNS)
Shanghai Shengdi Pharmaceutical Co., Ltd306 enrolled2 locationsNCT07275723
Recruiting
Phase 2Phase 3
Post-thrombectomy Intra-arterial Tenecteplase for Acute manaGement of Non-retrievable Thrombus and No-reflow in Emergent Stroke
Central Nervous System DiseasesCerebrovascular DisordersIschemic Stroke, Acute+1 more
University of Melbourne462 enrolled13 locationsNCT05892510
Recruiting
Phase 3
Adjusted High-dose Chemotherapy With Autologous Stem Cell Transplant vs. Conventional Immunochemotherapy in Elderly PCNSL Patients
Primary Central Nervous System Lymphoma
University Hospital Freiburg340 enrolled35 locationsNCT06830421
Recruiting
Phase 3
Azathioprine in MOGAD
Central Nervous System InflammationMOG-IgG Associated Disease
Hospices Civils de Lyon126 enrolled17 locationsNCT05349006
Recruiting
Phase 3
Nebulized Ketamine for the Treatment of Major Depressive Disorder in an Inpatient Setting
MidazolamDepressive SymptomSevere Depression+16 more
Theresa Jacob, PhD, MPH40 enrolled1 locationNCT06752759
Recruiting
Phase 2Phase 3
Therapeutic Effects of R-IDARAM and Intrathecal Immunochemotherapy on Elderly Patients With PCNSL
Primary Central Nervous System Lymphoma
Navy General Hospital, Beijing100 enrolled1 locationNCT02836158
Recruiting
Phase 2Phase 3
Treatment of PCNSL With R-IDARAM and Intrathecal Immunochemotherapy
Primary Central Nervous System Lymphoma
Navy General Hospital, Beijing100 enrolled1 locationNCT02657785
Withdrawn
Phase 3
Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma
Brain and Central Nervous System Tumors
Alliance for Clinical Trials in Oncology360 enrolled66 locationsACTRN12620000402943
Completed
Phase 3
A clinical study to determine the safety and efficacy of gadobutrol 1.0 molar (Gadovist 'Registered trade mark') in comparison to ProHance 'Registered trade mark' (gadoteridol) 0.5 molar in patients referred for contrast-enhanced Magnetic Resonance Imaging (MRI) of the central nervous system.
Central nervous system diseases requiring a contrast-enhanced MRI of the CNS.
Bayer Australia Ltd402 enrolled7 locationsACTRN12608000455369
Active
Phase 3
Radiation Therapy or Temozolomide in Treating Patients With Gliomas
Brain and Central Nervous System Tumors
European Organisation for Research and Tretment of Cancer (EORTC)699 enrolled34 locationsACTRN12607000427471
Terminated
Phase 3
QUARTZ - Quality of Life After Radiotherapy and Steroids
Lung CancerBrain and Central Nervous System Tumors
Tanya Holt1,000 enrolled1 locationACTRN12607000264482
Completed
Phase 3
A study comparing the efficacy and safety of once-daily oral rivaroxaban with warfarin for the prevention of stroke and embolism in patients with atrial fibrillation.
StrokeNon-central nervous system systemic embolism in subjects with non-valvular atrial fibrillation.
Bayer Australia Limited14,269 enrolled1 locationACTRN12607000214437