Chondral Defect Clinical Trials

14 recruitingLast updated: May 21, 2026

There are 14 actively recruiting chondral defect clinical trials across 8 countries. Studies span Not Applicable, Phase 3. Top locations include Houston, Texas, United States, Boston, Massachusetts, United States, Aurora, Illinois, United States. Updated daily from ClinicalTrials.gov.


Chondral Defect Trials at a Glance

14 actively recruiting trials for chondral defect are listed on ClinicalTrialsFinder across 6 cities in 8 countries. The largest study group is Not Applicable with 6 trials, with the heaviest enrollment activity in Houston, Boston, and Aurora. Lead sponsors running chondral defect studies include Massachusetts General Hospital, Vericel Corporation, and Centre Hospitalier Universitaire Vaudois.

Browse chondral defect trials by phase

About Chondral Defect Clinical Trials

Looking for clinical trials for Chondral Defect? There are currently 7 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Chondral Defect trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Chondral Defect clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 114 of 14 trials

Recruiting

The Biomechanical Outcomes of Autologous Chondrocyte Implantation

Chondral Defect
University of Manchester47 enrolled7 locationsNCT06921889
Recruiting
Not Applicable

Descriptive Study of the Reconstruction of Osteochondral Lesions of the Knee: Clinical and Imaging Results

osteochondral defect
Versailles Hospital130 enrolled1 locationNCT03908931
Recruiting
Not Applicable

Introduction of ACI for Cartilage Repair

Chondral DefectArticular Cartilage DefectOsteochondritis
Centre Hospitalier Universitaire Vaudois218 enrolled1 locationNCT04296487
Recruiting
Phase 3

A Study of MACI in Patients Aged 17 to 65 Years With Symptomatic Chondral or Osteochondral Defects of the Ankle

Chondral DefectArticular Cartilage Defect
Vericel Corporation309 enrolled4 locationsNCT06915233
Recruiting
Not Applicable

A Study on Reducing Opioid Use After Minimally Invasive Ankle Surgery

Opioid analgesiaAnkle sprainAnkle (Ligaments); Instability (Old Injury)+2 more
Second Affiliated Hospital, School of Medicine, Zhejiang University110 enrolled1 locationNCT07154433
Recruiting

Evaluation of Clinical and Radiological Outcomes in Patients Undergoing Fixation of Osteochondral Fragments With Reasorbable Screws in the Knee Joint

osteochondral defectOsteochondritis DissecansOsteochondral Fracture+1 more
Istituto Ortopedico Rizzoli100 enrolled1 locationNCT06462040
Recruiting
Not Applicable

Evaluating Cryopreserved Osteochondral Allograft Cores for the Treatment of Osteochondral Lesions in the Knee

osteochondral defect
AlloSource68 enrolled6 locationsNCT06216756
Recruiting

Use of BMAC With Hip Arthroscopy Treatment of FAI and Labral Tear

Chondral DefectBone Marrow Aspirate ConcentrateAcetabular Labrum Tear+2 more
Massachusetts General Hospital400 enrolled1 locationNCT03909139
Recruiting
Not Applicable

BioPoly® Partial Resurfacing Knee Implant IDE

Knee OsteoarthritisKnee Pain ChronicCartilage Damage+3 more
BioPoly LLC152 enrolled1 locationNCT06915363
Recruiting
Phase 3

A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee

Chondral DefectOsteochondritis Dissecans (OCD)Articular Cartilage Defect+1 more
Vericel Corporation45 enrolled12 locationsNCT03588975
Recruiting
Phase 3

Effect of PRP, PPP, & BMAC on Functional Outcomes Following Hip Arthroscopy for Acetabular Labral Pathologies

Chondral DefectBone Marrow Aspirate ConcentrateAcetabular Labrum Tear+1 more
Massachusetts General Hospital160 enrolled1 locationNCT06003101
Recruiting

Knee Registry (Knieregister)

osteochondral defectOsteoarthritis, KneeChondral Defect+2 more
UMC Utrecht1,000,000 enrolled1 locationNCT04364334
Recruiting

Study Protocol to Evaluate Clinical and Imaging Results of Knee Fresh Osteochondral Allografts

osteochondral defect
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau40 enrolled1 locationNCT04236492
Recruiting
Not Applicable

Clinical and Radiographic Outcomes After AMIC Treatment for Talus Osteochondral Lesion Trattamento Artroscopico Delle Lesioni Osteocondrali Dell'Astragalo Con Tecnica AMIC

ArthroscopyPainTalar Osteochondral Defect of Ankle
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio103 enrolled1 locationNCT03371121