Clear Cell Renal Cell Carcinoma Clinical Trials

53 recruitingLast updated: June 17, 2026

There are 53 actively recruiting clear cell renal cell carcinoma clinical trials across 23 countries. Studies span Phase 2, Phase 1, Phase 3, Early Phase 1, Not Applicable. Top locations include Duarte, California, United States, Houston, Texas, United States, Dallas, Texas, United States. Updated daily from ClinicalTrials.gov.


Clear Cell Renal Cell Carcinoma Trials at a Glance

53 actively recruiting trials for clear cell renal cell carcinoma are listed on ClinicalTrialsFinder across 6 cities in 23 countries. The largest study group is Phase 2 with 25 trials, with the heaviest enrollment activity in Duarte, Houston, and Dallas. Lead sponsors running clear cell renal cell carcinoma studies include City of Hope Medical Center, M.D. Anderson Cancer Center, and Chinese PLA General Hospital.

Browse clear cell renal cell carcinoma trials by phase

Treatments under study

About Clear Cell Renal Cell Carcinoma Clinical Trials

Looking for clinical trials for Clear Cell Renal Cell Carcinoma? There are currently 27 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Clear Cell Renal Cell Carcinoma trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Clear Cell Renal Cell Carcinoma clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 53 trials

Recruiting
Phase 2

An Investigational Scan (89Zr-DFO-GmAb PET/CT) Compared to Contrast-Enhanced CT for the Detection of Recurrent Clear Cell Renal Cell Cancer After Surgery Comparing Carbonic Anhydrase IX (CAIX) PET CT to Conventional PET CT for Post-Op Staging in Kidney Cancer

Clear Cell Renal Cell CarcinomaSarcomatoid Renal Cell CarcinomaStage III Renal Cell Cancer+2 more
Jonsson Comprehensive Cancer Center91 enrolled1 locationNCT06447103
Recruiting
Phase 2

Phase II Trial of Single Agent Belzutifan or Pembrolizumab Versus Combination as Neoadjuvant Therapy in Clear Cell Renal Cell Carcinoma (BLAZE)

Clear Cell Renal Cell Carcinoma
M.D. Anderson Cancer Center10 enrolled1 locationNCT07187778
Recruiting
Phase 3

Adding Biotherapy or Placebo to Standard Treatment for Advanced Kidney Cancer

Stage III Renal Cell Cancer AJCC v8Stage IV Renal Cell Cancer AJCC v8Metastatic Clear Cell Renal Cell Carcinoma+1 more
SWOG Cancer Research Network718 enrolled41 locationsNCT07383441
Recruiting
Early Phase 1

The Safety and Efficacy of Allogeneic CD70 CAR-T Therapy in Unresectable or Metastatic Clear Cell Renal Cell Carcinoma

Unresectable or Metastatic Clear Cell Renal Cell Carcinoma
Chinese PLA General Hospital30 enrolled3 locationsNCT07645690
Recruiting
Phase 1

Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma
Xencor, Inc.307 enrolled26 locationsNCT05433142
Recruiting
Phase 2

Ivonescimab Prior to Surgery for the Treatment of High-Risk Localized Clear Cell Renal Cell Cancer

Stage III Renal Cell Cancer AJCC v8Stage IV Renal Cell Cancer AJCC v8Stage II Renal Cell Cancer AJCC v8+2 more
City of Hope Medical Center31 enrolled1 locationNCT07226544
Recruiting
Phase 2

Adding a Live Biotherapeutic Product (CBM588) to Pembrolizumab for the Treatment of Renal Cell Cancer After Surgery

Stage III Renal Cell Cancer AJCC v8Stage IV Renal Cell Cancer AJCC v8Clear Cell Renal Cell Carcinoma+2 more
City of Hope Medical Center62 enrolled2 locationsNCT07037004
Recruiting
Phase 1

KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors

Non-small Cell Lung Cancer (NSCLC)Pancreatic Ductal Adenocarcinoma (PDAC)Colorectal Cancer (CRC)+4 more
Kura Oncology, Inc.300 enrolled38 locationsNCT06026410
Recruiting
Phase 1Phase 2

Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer

Metastatic Renal Cell CarcinomaCarcinoma, Renal CellAdvanced Renal Cell Carcinoma+10 more
Pfizer224 enrolled109 locationsNCT07227415
Recruiting
Phase 2

VSV-IFNβ-NIS With Ipilimumab and Nivolumab for the Treatment of Advanced or Metastatic Clear Cell Renal Cell Carcinoma

Stage III Renal Cell Cancer AJCC v8Stage IV Renal Cell Cancer AJCC v8Metastatic Clear Cell Renal Cell Carcinoma+1 more
Mayo Clinic18 enrolled1 locationNCT07510334
Recruiting
Phase 2

Radiopharmaceutical Treatment of Advanced Kidney Cancer

Metastatic Clear Cell Renal Cell Carcinoma
European Organisation for Research and Treatment of Cancer - EORTC48 enrolled2 locationsNCT06783348
Recruiting
Phase 3

Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer

Renal Cell Carcinoma (RCC)Clear Cell Renal Cell CarcinomaStage II Renal Pelvis Cancer AJCC v8+1 more
Alliance for Clinical Trials in Oncology1,040 enrolled414 locationsNCT06661720
Recruiting
Phase 3

Study of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma

Metastatic Clear Cell Renal Cell CarcinomaAdvanced Clear Cell Renal Cell Carcinoma
Arcus Biosciences, Inc.720 enrolled118 locationsNCT07011719
Recruiting
Phase 1

Open-Label Phase 1/2 Study of NEO-811 in Subjects With Locally Advanced or Metastatic Non-Resectable Clear Cell Renal Cell Carcinoma

Renal Cell CarcinomaClear Cell Renal Cell CarcinomaKidney Cancers+6 more
Neomorph, Inc30 enrolled10 locationsNCT07300241
Recruiting
Phase 1

A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid Tumors

Solid TumorsClear Cell Renal Cell Carcinoma
Arcus Biosciences, Inc.362 enrolled25 locationsNCT05536141
Recruiting
Phase 1

Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

Head and Neck Squamous Cell Carcinoma (HNSCC)Non-small Cell Lung Cancer (NSCLC)Solid Tumor+7 more
Exelixis1,314 enrolled122 locationsNCT05176483
Recruiting
Phase 2

Belzutifan's Role in Active Surveillance Versus Treatment for Indolentmetastatic Clear Cell Renal Ccell Carcinoma (BRAVE-RCC)

Clear Cell Renal Cell CarcinomaActive Surveillance
M.D. Anderson Cancer Center78 enrolled1 locationNCT07023432
Recruiting
Phase 2

Trial of Zanzalintinib (XL092) in Combination With Immunotherapy in Patients Who Progress on Adjuvant Therapy in Clear Cell RCC

Metastatic Renal Cell CarcinomaAdvanced Renal Cell CarcinomaClear Cell Renal Cell Carcinoma
Karie Runcie70 enrolled4 locationsNCT06863311
Recruiting
Phase 1

Immunotherapy (Nivolumab and Ipilimumab) With and Without a Live Biotherapeutic Product (EXL01) for the Treatment of Metastatic Renal Cell Cancer

Stage III Renal Cell Cancer AJCC v8Stage IV Renal Cell Cancer AJCC v8Metastatic Clear Cell Renal Cell Carcinoma+3 more
City of Hope Medical Center33 enrolled2 locationsNCT07128680
Recruiting

Evaluation of Urinary Exosomes Presence From Clear Cell Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma
Centre Hospitalier Universitaire de Saint Etienne100 enrolled1 locationNCT04053855