Advanced Cancer Clinical Trials

91 recruiting

Advanced Cancer Trials at a Glance

92 actively recruiting trials for advanced cancer are listed on ClinicalTrialsFinder across 6 cities in 32 countries. The largest study group is Phase 1 with 41 trials, with the heaviest enrollment activity in Houston, Shanghai, and Boston. Lead sponsors running advanced cancer studies include M.D. Anderson Cancer Center, Chongqing Precision Biotech Co., Ltd, and Chia Tai Tianqing Pharmaceutical Group Co., Ltd..

Browse advanced cancer trials by phase

Treatments under study

About Advanced Cancer Clinical Trials

Looking for clinical trials for Advanced Cancer? There are currently 91 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Advanced Cancer trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Advanced Cancer clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 92 trials

Recruiting
Not Applicable

BOLSTER: Learning New Skills to Thrive

Advanced CancerGynecologic CancerGastrointestinal Cancer
Dana-Farber Cancer Institute600 enrolled2 locationsNCT06936878
Recruiting
Phase 1

A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815

Metastatic CancerAdvanced CancerSolid Tumor
Jazz Pharmaceuticals332 enrolled15 locationsNCT05557045
Recruiting
Phase 1

A Study of IMC-002 in Patients With Advanced Cancer Failed to Standard Therapy

Advanced Cancer
ImmuneOncia Therapeutics Inc.62 enrolled3 locationsNCT05276310
Recruiting
Phase 2

Toripalimab(JS001) as Monotherapy in Participants With POLE or POLD-1 Mutated and Non-MSI-H Advanced Solid Tumors

Advanced CancerSolid Tumor
Sun Yat-sen University35 enrolled4 locationsNCT03810339
Recruiting
Phase 1

A Study of PHN-012 in Patients With Advanced Solid Tumors

Pancreatic CancerColon CancerAdvanced Cancer+2 more
Pheon Therapeutics165 enrolled21 locationsNCT07127874
Recruiting
Phase 3

Combination of Immune Checkpoint in Locally Advanced or Metastatic MSI/dMMR Esogastric Adenocarcinomas

Gastric CancerMetastatic CancerAdvanced Cancer+1 more
Centre Leon Berard132 enrolled6 locationsNCT06346197
Recruiting
Phase 2

Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy

Advanced CancerDepression, AnxietyPsilocybin-Assisted Psychotherapy
M.D. Anderson Cancer Center30 enrolled1 locationNCT06200155
Recruiting
Phase 1Phase 2

Phase 1b/2 Study of Combination 177Lu Girentuximab Plus Cabozantinib and Nivolumab in Treatment naïve Patients With Advanced Clear Cell RCC

Advanced CancerClear Cell Renal Cell Carcinoma
M.D. Anderson Cancer Center100 enrolled1 locationNCT05663710
Recruiting
Not Applicable

A Pilot Randomized Controlled Trial of a Social Network Intervention

Advanced CancerOlder Adults (65 Years and Older)Social Networks
University of Rochester70 enrolled1 locationNCT07393529
Recruiting
Phase 2

CVM-1118 in Combination With Nivolumab for Unresectable Advanced Hepatocellular Carcinoma

Hepatocellular CarcinomaAdvanced Cancer
TaiRx, Inc.95 enrolled5 locationsNCT05257590
Recruiting
Phase 1Phase 2

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

MelanomaAdvanced Solid TumorMetastasis+5 more
7 Hills Pharma, LLC126 enrolled5 locationsNCT06362369
Recruiting
Not Applicable

A Chaplain-clinician Led Spiritual Care (PEACE) Intervention on Spiritual/Religious Beliefs Related to Medical Care in Patients With Advanced Cancer: a Pilot Clinical Trial

Advanced CancerSpiritual Care
M.D. Anderson Cancer Center60 enrolled1 locationNCT07246954
Recruiting
Phase 1Phase 2

Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

Breast CancerBreast Cancer MetastaticOvarian Cancer+6 more
Incyclix Bio150 enrolled18 locationsNCT05735080
Recruiting

SPECT Imaging for Pharmacokinetics and dosimEtry Towards TREATment Optimization

Prostate CancerAdvanced Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins80 enrolled1 locationNCT06389097
Recruiting
Not Applicable

Pilot Trial of Spiritual Care Interventions for Patients With Cancer

Advanced Cancer
Weill Medical College of Cornell University64 enrolled2 locationsNCT06811376
Recruiting
Phase 1Phase 2

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

Ovarian CancerEndometrial CancerMetastatic Cancer+6 more
Artios Pharma Ltd442 enrolled79 locationsNCT04657068
Recruiting
Not Applicable

Electronic Patient Reporting of Symptoms and Unmet Needs to Connect Patients With Advanced Cancer to Palliative Care Services

Advanced CancerMetastatic Cancer (Different Solid Tumour Types)Palliative Care, Health Services+1 more
Dartmouth-Hitchcock Medical Center90 enrolled1 locationNCT07195513
Recruiting
Phase 1Phase 2

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Antitumor Activity of ALK201 in Participants With Advanced Solid Tumors

Advanced CancerAdvanced Solid Tumors
Shanghai Allink Biotherapeutics Co., Ltd.202 enrolled2 locationsNCT06656390
Recruiting
Phase 1

Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors

Gastric CancerEsophageal AdenocarcinomaMetastatic Cancer+5 more
I-Mab Biopharma US Limited330 enrolled21 locationsNCT04900818
Recruiting
Phase 1Phase 2

A Study of Repotrectinib in Combination With Chemotherapy in Children and Young Adults With Solid Tumor Cancer

Metastatic Solid TumorAdvanced Cancer
Memorial Sloan Kettering Cancer Center77 enrolled1 locationNCT05004116