Advanced Cancer Clinical Trials

107 recruitingLast updated: June 17, 2026

There are 107 actively recruiting advanced cancer clinical trials across 33 countries. Studies span Phase 1, Phase 2, Not Applicable, Phase 3, Early Phase 1. Top locations include Houston, Texas, United States, Nashville, Tennessee, United States, Guangzhou, Guangdong, China. Updated daily from ClinicalTrials.gov.


Advanced Cancer Trials at a Glance

107 actively recruiting trials for advanced cancer are listed on ClinicalTrialsFinder across 6 cities in 33 countries. The largest study group is Phase 1 with 47 trials, with the heaviest enrollment activity in Houston, Nashville, and Guangzhou. Lead sponsors running advanced cancer studies include M.D. Anderson Cancer Center, Chia Tai Tianqing Pharmaceutical Group Co., Ltd., and Chongqing Precision Biotech Co., Ltd.

Browse advanced cancer trials by phase

Treatments under study

About Advanced Cancer Clinical Trials

Looking for clinical trials for Advanced Cancer? There are currently 100 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Advanced Cancer trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Advanced Cancer clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 107 trials

Recruiting

Evaluating Disparities in Precision Oncology

Metastatic CancerAdvanced Cancer
Indiana University10,600 enrolled1 locationNCT06081517
Recruiting
Phase 1

CT-95 in Advanced Cancers Associated With Mesothelin Expression

Colorectal, CancerMesothelin-Expressing TumorsEpithelial Ovarian Cancer+8 more
Context Therapeutics Inc.70 enrolled9 locationsNCT06756035
Recruiting

Psychophysical Studies of Cancer Therapy Pain

PainAdvanced Cancer
M.D. Anderson Cancer Center450 enrolled1 locationNCT00515060
Recruiting
Phase 1

MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors

Triple-Negative Breast CancerPancreatic CancerMelanoma+7 more
Memgen, Inc.40 enrolled2 locationsNCT05076760
Recruiting
Not Applicable

Simulation-Free Celiac Plexus Pain Ablation Using Stereotactic Body Radiotherapy in Patients With Cancer-Related Celiac Pain

Pancreatic CancerAdvanced Cancer
University Health Network, Toronto5 enrolled1 locationNCT07636382
Recruiting
Not Applicable

Resilience-Building for Advance Care Planning

Advanced CancerEnd of Life
University of Illinois at Chicago152 enrolled1 locationNCT07428278
Recruiting
Phase 1

A Study of PHN-012 in Patients With Advanced Solid Tumors

Pancreatic CancerColon CancerAdvanced Cancer+2 more
Pheon Therapeutics165 enrolled20 locationsNCT07127874
Recruiting
Phase 1Phase 2

A Study of Repotrectinib in Combination With Chemotherapy in Children and Young Adults With Solid Tumor Cancer

Metastatic Solid TumorAdvanced Cancer
Memorial Sloan Kettering Cancer Center77 enrolled1 locationNCT05004116
Recruiting
Not Applicable

Trial of Spiritual Care Interventions for Patients With Cancer

Advanced Cancer
Weill Medical College of Cornell University288 enrolled3 locationsNCT07408310
Recruiting
Phase 1Phase 2

Phase 1/2 Study of UI-102 in Selected Advanced Cancers

Advanced Cancer
United Immunity, co., Ltd.140 enrolled3 locationsNCT07605962
Recruiting
Phase 1

An Open-Label Study to Evaluate PF-07994525 in Participants With Advanced Cancers

Advanced CancerAdvanced Malignancies
Pfizer120 enrolled4 locationsNCT07426757
Recruiting
Phase 1Phase 2

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Antitumor Activity of ALK201 in Participants With Advanced Solid Tumors

Advanced CancerAdvanced Solid Tumors
Shanghai Allink Biotherapeutics Co., Ltd.202 enrolled38 locationsNCT06656390
Recruiting
Early Phase 1

A Phase I Study on Evaluating the Safety, Tolerability, Pharmacokinetic Characteristics and Preliminary Efficacy of SXRN Plasmid DNA Technique in Patients With Advanced Solid Tumors

Advanced CancerCachexia
Jiangsu Nutai Biologics Co., Ltd28 enrolled1 locationNCT06736275
Recruiting
Phase 1

Samarium Optimized for Long-lasting Analgesia in Cancerous End-stage Bone Pain

Bone PainMetastatic Bone TumorBone Metastases in Subjects With Advanced Cancer
Telix Pharmaceuticals (Innovations) Pty Limited33 enrolled6 locationsNCT07197645
Recruiting
Phase 2

Timely Integration of Palliative Care in Oncology Care for Patients Referred for Palliative Radiotherapy on Bone Metastases: A Randomized Trial

RadiotherapyBone Metastases in Subjects With Advanced Cancer
Roxanne Gal246 enrolled5 locationsNCT06805396
Recruiting
Phase 2

Givastomig Combined With Nivolumab and Chemotherapy in Adults With CLDN18.2 Positive Metastatic Gastric Cancer (GIVA-2)

Gastric CancerEsophageal AdenocarcinomaMetastatic Cancer+3 more
I-Mab Biopharma US Limited180 enrolled6 locationsNCT07432295
Recruiting
Not Applicable

Longitudinal Screening for Financial Hardship to Improve Outcomes in Patients With Advanced Cancer

Metastatic CancerAdvanced Cancer
Alliance Foundation Trials, LLC.1,000 enrolled7 locationsNCT06963723
Recruiting
Early Phase 1

Pilot Study of [68Ga]Ga-ABY-025 Imaging in Patients Undergoing Treatment With HER2-targeted Therapy

Metastatic CancerHER2Locally Advanced Cancer+2 more
Vanderbilt-Ingram Cancer Center30 enrolled1 locationNCT06828588
Recruiting
Phase 1Phase 2

Phase 1b/2 Study of Combination 177Lu Girentuximab Plus Cabozantinib and Nivolumab in Treatment naïve Patients With Advanced Clear Cell RCC

Advanced CancerClear Cell Renal Cell Carcinoma
M.D. Anderson Cancer Center100 enrolled1 locationNCT05663710
Recruiting
Not Applicable

ALIGN for Older Adults With Cancer in SNFs

Advanced Cancer
University of Colorado, Denver120 enrolled1 locationNCT06616298