Phase 2 CLL Clinical Trials
22 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 22 trials
Recruiting
Phase 2
A Study of NX-5948 in Adults With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor and a B-cell Lymphoma-2 Inhibitor (DAYBreak CLL-201)
Chronic Lymphocytic Leukemia (CLL)Small Lymphocytic Lymphoma (SLL)
Nurix Therapeutics, Inc.100 enrolled20 locationsNCT07221500
Recruiting
Phase 1Phase 2
Adaptive Dual-Target CAR-T Cells for Relapsed or Refractory Hematologic Malignancies
T-lymphoblastic LymphomaRelapsed/Refractory B-cell Acute Lymphoblastic LeukemiaRelapsed/Refractory B-cell Non-Hodgkin Lymphoma or CLL/SLL+3 more
Beijing Biotech96 enrolled1 locationNCT07523555
Recruiting
Phase 2
Study of Zanubrutinib, Obinutuzumab, and Venetoclax in Patients With Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL)
Chronic Lymphocytic Leukemia (CLL)Small Lymphocytic Leukemia (SLL)
Memorial Sloan Kettering Cancer Center230 enrolled8 locationsNCT03824483
Recruiting
Phase 2
A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation
LymphomaMyelofibrosisAML (Acute Myelogenous Leukemia)+8 more
Center for International Blood and Marrow Transplant Research358 enrolled13 locationsNCT06859424
Recruiting
Phase 1Phase 2
A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies
Acute Lymphoblastic LeukemiaAcute Myeloid LeukemiaAcute Leukemia+8 more
Ossium Health, Inc.12 enrolled9 locationsNCT05589896
Recruiting
Phase 2
Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax With Intravenous (IV) Obinutuzumab in Adult Participants With Recurring Chronic Lymphocytic Leukemia (CLL)
Chronic Lymphocytic Leukemia (CLL)
AbbVie75 enrolled58 locationsNCT04895436
Recruiting
Phase 2
Intermittent Versus Continuous Venetoclax With Acalabrutinib for CLL/SLL
Chronic Lymphocytic LeukemiaSmall Lymphocytic LymphomaCLL Variant
Zulfa Omer62 enrolled1 locationNCT07014917
Recruiting
Phase 2
REtreatment With VEnetoclax and Acalabrutinib After Venetoclax Limited Duration (REVEAL)
CLL/SLL
Stichting Hemato-Oncologie voor Volwassenen Nederland60 enrolled18 locationsNCT04523428
Recruiting
Phase 2
Study of Epcoritamab as a Consolidation Therapy in CLL/SLL
Chronic Lymphocytic LeukemiaSmall Lymphocytic LymphomaCLL+4 more
Zulfa Omer22 enrolled1 locationNCT07108998
Recruiting
Phase 2
A Study of Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Chronic Lymphocytic Leukemia (CLL)Small Lymphocytic Lymphoma (SLL)
AbbVie110 enrolled31 locationsNCT02966756
Recruiting
Phase 2
Zanubrutinib and Venetoclax in CLL (ZANU-VEN)
Chronic Lymphocytic Leukemia (CLL)Small Lymphocytic Lymphoma (SLL)
Dana-Farber Cancer Institute45 enrolled4 locationsNCT05168930
Recruiting
Phase 2
Venetoclax as Consolidation in CLL Patients Treated With BTK Inhibitor Monotherapy
Chronic Lymphocytic Leukemia (CLL) / Small Lymphocytic Lymphoma (SLL)
The First Affiliated Hospital with Nanjing Medical University79 enrolled1 locationNCT06958705
Recruiting
Phase 2
LP-168 and Obinutuzumab for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) and Variants of This
Chronic Lymphocytic LeukemiaSmall Lymphocytic LymphomaCLL/SLL+1 more
Zulfa Omer34 enrolled1 locationNCT06978088
Recruiting
Phase 1Phase 2
A Phase 1/2 Study of IDP-121 in Patients With Relapsed/Refractory Hematologic Malignancies
Chronic Lymphocytic Leukemia (CLL)High Grade B-Cell Lymphoma, Not Otherwise SpecifiedMultiple Myeloma (MM)+3 more
IDP Discovery Pharma S.L.37 enrolled11 locationsNCT05908409
Recruiting
Phase 1Phase 2
Safety and Efficacy of KLS-1 Monotherapy in Malignant Neoplasms
Solid Tumor, AdultCLL
Vector Vitale LLC36 enrolled1 locationNCT06506643
Recruiting
Phase 1Phase 2
Allogeneic CARCIK-CD19 in Adults/Pediatric B-cell NHL or Chronic Lymphocytic Leukemia
CLLB-cell NHL
Fondazione Matilde Tettamanti Menotti De Marchi Onlus29 enrolled1 locationNCT05869279
Recruiting
Phase 1Phase 2
Venetoclax Treatment (26 Cycles) With 6 Cycles or 12 Cycles of Epcoritamab in Patients With Relapsed or Refractory CLL or SLL
CLL/SLL
Stichting Hemato-Oncologie voor Volwassenen Nederland112 enrolled24 locationsNCT05791409
Recruiting
Phase 2Phase 3
Acalabrutinib and Venetoclax Treatment of Newly Diagnosed Patients With CLL at High Risk of Infection or Early Treatment
CLL
Rigshospitalet, Denmark212 enrolled7 locationsNCT03868722
Recruiting
Phase 2
Ibrutinib for the Treatment of AIHA in Patients With CLL/SLL or CLL-like MBL
Chronic Lymphocytic LeukemiaSmall Lymphocytic LymphomaAutoimmune Hemolytic Anemia+1 more
Gruppo Italiano Malattie EMatologiche dell'Adulto45 enrolled3 locationsNCT05694312
Recruiting
Phase 2
Venetoclax, Rituximab and Ibrutinib in TN Patients With CLL Undetectable Minimal Residual Disease (uMRD) in Treatment-naïve Patients With Chronic Lymphocytic Leukemia (CLL)
Chronic Lymphocytic Leukemia (CLL)
Paolo Ghia55 enrolled1 locationNCT04758975