Clostridioides Difficile Infection Clinical Trials

22 recruitingLast updated: May 21, 2026

There are 22 actively recruiting clostridioides difficile infection clinical trials across 32 countries. Studies span Phase 3, Phase 2, Not Applicable, Phase 1. Top locations include Minneapolis, Minnesota, United States, Idaho Falls, Idaho, United States, Atlanta, Georgia, United States. Updated daily from ClinicalTrials.gov.


Clostridioides Difficile Infection Trials at a Glance

22 actively recruiting trials for clostridioides difficile infection are listed on ClinicalTrialsFinder across 6 cities in 32 countries. The largest study group is Phase 3 with 6 trials, with the heaviest enrollment activity in Minneapolis, Idaho Falls, and Atlanta. Lead sponsors running clostridioides difficile infection studies include The Second Hospital of Nanjing Medical University, University of Minnesota, and Benoit Guery.

Browse clostridioides difficile infection trials by phase

About Clostridioides Difficile Infection Clinical Trials

Looking for clinical trials for Clostridioides Difficile Infection? There are currently 16 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Clostridioides Difficile Infection trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Clostridioides Difficile Infection clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 22 trials

Recruiting
Phase 1Phase 2

Evaluation of EXL01, a New Live Biotherapeutic Product to Prevent Recurrence of Clostridioides Difficile Infection in High-risk Patients

Clostridioides Difficile InfectionRecurrent Infection
Hospices Civils de Lyon56 enrolled9 locationsNCT06306014
Recruiting
Phase 1

Fecal Microbiota Transplantation in an Expanded Ulcerative Colitis Population

Inflammatory Bowel DiseasesUlcerative ColitisClostridioides Difficile Infection
University of Alberta85 enrolled2 locationsNCT07401680
Recruiting
Phase 2

Prevention of Recurrent C. Difficile Infection Study With AZD5148 Monoclonal Antibody

Clostridioides Difficile Infection
AstraZeneca230 enrolled114 locationsNCT07285213
Recruiting
Phase 3

FMT Capsules for rCDI

FMTClostridioides Difficile Infection Recurrence
Helsinki University Central Hospital76 enrolled1 locationNCT07458984
Recruiting
Phase 3

VE303 for Prevention of Recurrent Clostridioides Difficile Infection

Clostridium Difficile Infection RecurrenceClostridium DifficileClostridioides Difficile Infection+7 more
Vedanta Biosciences, Inc.852 enrolled215 locationsNCT06237452
Recruiting
Phase 1

Intestinal Microbiota Transplantation in Patients Undergoing Colon Resection

Recurrent Clostridioides difficile infectionColonic Surgery
University of Minnesota40 enrolled1 locationNCT06370884
Recruiting

Changes in Recipients Gut Microbiota After Fecal Microbiota Transplantation

Clostridioides Difficile Infection Recurrence
Fondazione Policlinico Universitario Agostino Gemelli IRCCS20 enrolled1 locationNCT05739825
Recruiting
Phase 2Phase 3

LMN-201 for Prevention of C. Difficile Infection Recurrence

Clostridioides Difficile Infection
Lumen Bioscience, Inc.375 enrolled16 locationsNCT05330182
Recruiting

Clostridioides Difficile: Understanding Responses and Treatment Effects

Clostridioides Difficile Infection
Umeå University200 enrolled1 locationNCT07374094
Recruiting

C. Difficile Toxin Levels in Stool From Healthy Individuals Following Standard of Care Antibiotic Treatment for CDI.

Clostridioides Difficile Infection Recurrence
Bactolife A/S60 enrolled1 locationNCT07250724
Recruiting
Phase 1

An Open-Label, Pilot Clinical Trial To Test The Safety And Feasibility Of A Suspension of Freeze-dried Microbiota In Patients Undergoing Colon Resection

Recurrent Clostridioides difficile infectionColonic Surgery
University of Minnesota40 enrolled1 locationNCT06692179
Recruiting
Phase 2Phase 3

Secondary Prevention of Clostridioides Difficile Using Vancomycin

Clostridioides Difficile InfectionClostridioides Difficile Infection RecurrenceClostridoides Difficile Associated Disease
McGill University Health Centre/Research Institute of the McGill University Health Centre300 enrolled1 locationNCT06979609
Recruiting
Phase 3

Fecal Microbiota Transplantation in Clostridioides Difficile Infection First Episode and First Recurrence

Clostridioides Difficile Infection
Benoit Guery220 enrolled7 locationsNCT05266807
Recruiting
Not Applicable

FMT in Initial CDI

Clostridioides Difficile Infection
Turku University Hospital140 enrolled1 locationNCT05257538
Recruiting
Not Applicable

Evaluation of GeoHAI Implementation

Clostridioides Difficile Infection
Ohio State University25 enrolled1 locationNCT05612672
Recruiting
Not Applicable

Prevention of Clostridium Difficile Infections Using Lactobacillus Plantarum 299v Strain in Nephrology and Transplantation Department

Clostridioides Difficile Infection
Medical University of Silesia300 enrolled1 locationNCT06859437
Recruiting

Study of Clostridioides Difficile in Infants

Clostridioides Difficile Infection
Westlake University300 enrolled1 locationNCT06788769
Recruiting
Phase 2

Alanyl-glutamine Supplementation for C. Difficile Treatment (ACT)

Clostridium Difficile InfectionClostridioides Difficile InfectionClostridium Difficile Diarrhea+1 more
University of Virginia260 enrolled2 locationsNCT04305769
Recruiting
Not Applicable

Lyophilized Fecal Microbiome Transfer vs. Vancomycin Monotherapy for Primary Clostridioides Difficile Infection

Clostridioides Difficile Infection
Rambam Health Care Campus196 enrolled6 locationsNCT05709184
Recruiting

Rescue Fecal Microbiota Transplantation for National Refractory Intestinal Infections

Antibiotic-Associated DiarrheaClostridioides Difficile InfectionIntestinal Infection
The Second Hospital of Nanjing Medical University100 enrolled1 locationNCT03895593