Phase 2 DED Clinical Trials
14 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–14 of 14 trials
Recruiting
Phase 2Phase 3
A Clinical Study Evaluating Licaminlimab for Dry Eye Disease
Dry Eye Disease (DED)
Oculis160 enrolled10 locationsNCT07548632
Recruiting
Phase 2
Visugromab, Nivolumab and Lenvatinib Compared to Double Placebo and Lenvatinib in Unresectable or Metastatic Hepatocellular Carcinoma Post Anti-PD-(L)1 Failure
Unresectable or Metastatic Hepatocellular CarcinomaChild-Pugh A Hepatocellular CarcinomaFailure of First-Line Treatment That Included an Approved Anti PD-(L)1 Compound
CatalYm GmbH104 enrolled2 locationsNCT07219459
Recruiting
Phase 2
Testing Nivolumab With or Without Ipilimumab in Deficient Mismatch Repair System (dMMR) Recurrent Endometrial Carcinoma
Recurrent Endometrial CarcinomaEndometrial AdenocarcinomaEndometrial Clear Cell Adenocarcinoma+6 more
National Cancer Institute (NCI)81 enrolled137 locationsNCT05112601
Recruiting
Phase 1Phase 2
STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants With Selected Sarcomas
SarcomaSolid TumorLeiomyosarcoma+1 more
STORM Therapeutics LTD107 enrolled6 locationsNCT06975293
Recruiting
Phase 1Phase 2
Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma
Metastatic Soft Tissue SarcomaMetastatic LeiomyosarcomaAdvanced Soft Tissue Sarcoma+5 more
National Cancer Institute (NCI)74 enrolled1 locationNCT06498648
Recruiting
Phase 2Phase 3
Efficacy Testing of a Multi-Level Family Planning Intervention
Unintended pregnancyFamily Planning
Boston College1,464 enrolled1 locationNCT06923189
Recruiting
Phase 1Phase 2
A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma
LiposarcomaDedifferentiated LiposarcomaPleomorphic Liposarcoma+6 more
Memorial Sloan Kettering Cancer Center54 enrolled7 locationsNCT06843967
Recruiting
Phase 2
Pre-transplant Purging and Post-transplant MRD-guided Maintenance Therapy With Elranatamab in Patients With High-risk Multiple Myeloma
Multiple MyelomaPost-transplant MRD-guided Maintenance TherapyPre-transplant Purging
M.D. Anderson Cancer Center40 enrolled1 locationNCT06207799
Recruiting
Phase 2
Elimination of PTV Margins Based on MRI-guided Adaptive Stereotactic Radiotherapy for Non-small Cell Lung Cancer With Brain Metastasis
Non-small Cell Lung CancerBrain MetastasisMRI-guided Adaptive Radiotherapy
Sun Yat-sen University168 enrolled1 locationNCT06582940
Recruiting
Phase 2
A Phase 2, Open Label Study of PEmigatinib and REtifanlimab in Advanced Dedifferentiated LIposarcoma (PERELI)
Dedifferentiated Liposarcoma
Lund University Hospital33 enrolled4 locationsNCT06389799
Not Yet Recruiting
Phase 2
Efficacy of assigning treatment for participants with VEXAS syndrome with lenzilumab plus azacitidine
V - vacuoles are often seen in cells identified in bone marrow biopsies from patients with VEXAS syndrome.
E - E1 ubiquitin activating enzyme, encoded by the UBA1 gene which is mutated in patients
X - the UBA1 gene is located on the X chromosome.
A - patients have autoinflammation.
S - the mutations are somatic, meaning they are acquired at some point in life and not inherited.
(VEXAS)
South Australian Health & Medical Research Institute Ltd10 enrolled1 locationACTRN12625000619448
Recruiting
Phase 2
Neoantigen Vaccines in Esophageal Squamous Cell Carcinoma
Esophageal Squamous Cell Carcinoma (ESCC)Neoantigen-loaded Dendritic Cell VaccineImmune Checkpoint Inhibitors (ICIs)
Sichuan University165 enrolled1 locationNCT06675201
Recruiting
Phase 2
Biomarcer-2 :Biomarker informed optimal management of advanced RAS wild type colorectal cancer
Advanced RAS Wild type right sided Colorectal cancer
Australasian Gastrointestinal Trials Group29 enrolled12 locationsACTRN12623000874617
Active
Phase 2Phase 3
Clinical Investigation of the Extended Range of Vision (ERV) Intraocular Lenses (IOLs), Model XRA03 and Toric Series ZXT in Participants Requiring Bilateral Cataract Removal and Lens Replacement.
Bilateral Cataract removal and replacment of crystalline lens with an investigational extended range of vision IOL, in otherwise healthy eyes
Abbott Medical Optics Inc75 enrolled1 locationACTRN12613001189718