Early Phase 1 Depressive Clinical Trials
7 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–7 of 7 trials
Recruiting
Early Phase 1
Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine
Major Depressive Disorder (MDD)
University of Pennsylvania10 enrolled1 locationNCT06788249
Recruiting
Early Phase 1
Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
DepressionDepressive SymptomsAlzheimer Disease+1 more
Johns Hopkins University20 enrolled1 locationNCT04123314
Recruiting
Early Phase 1
Mood Effects of Serotonin Agonists: Depression
DepressionMajor Depressive DisorderLSD
University of Chicago48 enrolled1 locationNCT07017478
Recruiting
Early Phase 1
Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder
Major Depressive DisorderBipolar Depression
Massachusetts General Hospital20 enrolled1 locationNCT03748446
Recruiting
Early Phase 1
Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine
Major Depressive Disorder
Emory University140 enrolled1 locationNCT05327699
Terminated
Early Phase 1
Exploratory trial to assess the efficacy and safety of Psilocybin-Assisted Psychotherapy (PAP) involving family-members compared to standard PAP, in adults with treatment-resistant major depressive disorder. (TRMDD).
Treatment-resistant major depressive disorder (TRMDD).
Reset Mind Science60 enrolled1 locationACTRN12623000618651
Completed
Early Phase 1
A healthy mind in a healthy body: A two-group randomised pilot trial evaluating web-based physical activity interventions to improve mental and physical health in people with depression
Depressive Symptoms
Central Queensland University800 enrolled1 locationACTRN12613001215718