RecruitingEarly Phase 1NCT07017478

Mood Effects of Serotonin Agonists: Depression

Sponsor

University of Chicago

Enrollment

48 participants

Start Date

Jun 9, 2025

Study Type

INTERVENTIONAL

Conditions

Depression Major Depressive Disorder LSD

Summary

This study will examine the effect of a low dose of the 5HT2A agonist LSD (26 µg), compared to placebo, on acute and protracted mood states in individuals with depression. The investigators will assess the relationship between mood-related symptoms and EEG as a neurophysiological marker.

Eligibility

Min Age: 18 YearsMax Age: 40 Years

Inclusion Criteria3

English Fluency
high school education or higher
BMI between 19-30 kg/m2

Exclusion Criteria10

individuals with a medical condition contraindicating study participation as determined by the study physician (e.g., liver disease, abnormal EKG, liver or cardiovascular disease)
high blood pressure (\>140/90)
current suicidal ideation or suicide attempt in past 12 months
past year severe substance use disorder
personal or first-degree relative with history of psychosis
currently taking any psychiatric medication (for conventional antidepressants must be off for ≥ 2 weeks)
active panic disorder
severe obsessive-compulsive disorder
severe post-traumatic stress disorder
women who are pregnant or planning to become pregnant