Mood Effects of Serotonin Agonists: Depression

This study is investigating how drugs that activate serotonin receptors in the brain affect mood — specifically whether they may have antidepressant effects — in healthy volunteers or individuals with depression. **You may be eligible if...** - You are fluent in English - You have at least a high school education - Your BMI is between 19 and 30 kg/m² **You may NOT be eligible if...** - You have high blood pressure (above 140/90 mmHg) - You have a history of suicidal ideation or a suicide attempt in the past year - You have a serious substance use disorder in the past year - You or a first-degree family member has a history of psychosis - You are currently taking any psychiatric medication (or have been on conventional antidepressants within the last 2 weeks) - You have active panic disorder, severe OCD, or severe PTSD - You are pregnant or planning to become pregnant - You have liver or cardiovascular disease Talk to your doctor to see if this trial is right for you.