Phase 1 DM Clinical Trials
33 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 33 trials
Recruiting
Phase 1Phase 2
PBGENE-DMD Phase 1/2a Safety and Preliminary Efficacy Study in Duchenne Muscular Dystrophy (FUNCTION-DMD)
Duchenne Muscular Dystrophy With Mutations Amenable to PBGENE-DMD
Precision BioSciences, Inc.18 enrolled1 locationNCT07429240
Recruiting
Phase 1
A Study of FX-909 in Patients With Advanced Solid Malignancies, Including Advanced Urothelial Carcinoma
Advanced Urothelial CarcinomaOral Drug AdministrationOpen Label
Flare Therapeutics Inc.120 enrolled12 locationsNCT05929235
Recruiting
Phase 1
AMG 436 as Monotherapy and Combination Therapy in Participants With MSI-H/dMMR Solid Tumors
Metastatic or Locally Advanced Solid Tumors With Microsatellite Instability-high (MSI-H) or Mismatched Repair Deficiency (dMMR)
Amgen464 enrolled6 locationsNCT07403721
Recruiting
Phase 1Phase 2
A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM
Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled20 locationsNCT06845202
Recruiting
Phase 1
Phase I Study to Evaluate the Pharmacokinetics and Safety After Co-administration of L03RD1 and L03RD2 or Administration of L03TD1 in Healthy Volunteers
Type 2 Diabetes Mellitus (T2DM)
Celltrion48 enrolled1 locationNCT07533539
Recruiting
Phase 1Phase 2
EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors
Endometrial CancerAdvanced Solid TumorsMSI-H or dMMR Advanced Solid Tumors+4 more
Eikon Therapeutics160 enrolled10 locationsNCT07262619
Recruiting
Phase 1
Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)
Antiphospholipid Syndrome (APS)Immune-mediated Necrotizing Myopathy (IMNM)Immune Thrombocytopenia (ITP)+3 more
Chugai Pharmaceutical144 enrolled69 locationsNCT06371417
Recruiting
Phase 1
ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors
Central Nervous System TumorGlioblastomaCNS Tumor+5 more
Sabine Mueller, MD, PhD208 enrolled6 locationsNCT04732065
Recruiting
Phase 1
A Study of REGEND003 on Patients With Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD)
Type 2 Diabetes Mellitus (T2DM) and Chronic Kidney Disease (CKD)
Regend Therapeutics15 enrolled1 locationNCT07275788
Recruiting
Phase 1Phase 2
A Study in Participants With Duchenne Muscular Dystrophy Amenable to Exon 44 Skipping to Evaluate the Safety and Efficacy of ENTR-601-44
Duchenne Muscular Dystrophy (DMD)
Entrada Therapeutics, Inc.24 enrolled14 locationsNCT07037862
Recruiting
Phase 1Phase 2
CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D)
Type 1 DiabetesType 1 Diabetes MellitusType 1 Diabetes Mellitis+7 more
COUR Pharmaceutical Development Company, Inc.72 enrolled31 locationsNCT06783309
Recruiting
Phase 1Phase 2
A Study in Participants With Duchenne Muscular Dystrophy Amenable to Exon 45 Skipping to Evaluate the Safety and Efficacy of ENTR-601-45
Duchenne Muscular Dystrophy (DMD)
Entrada Therapeutics, Inc.24 enrolled15 locationsNCT07038824
Recruiting
Phase 1Phase 2
Safety, Tolerability, Pharmacodynamic, Efficacy, and Pharmacokinetic Study of DYNE-101 in Participants With Myotonic Dystrophy Type 1
Myotonic Dystrophy Type 1 (DM1)
Dyne Therapeutics116 enrolled17 locationsNCT05481879
Recruiting
Phase 1Phase 2
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Metabolic DiseaseDiabetes Mellitus, Type 1Type 1 Diabetes+14 more
Otsuka Pharmaceutical Factory, Inc.13 enrolled1 locationNCT06575426
Recruiting
Phase 1
Acute Effects of Intravenous 5-MeO-DMT in Healthy Participants
5-methoxy-dimethyltryptamine (5-MeO-DMT)
University Hospital, Basel, Switzerland40 enrolled1 locationNCT07444788
Recruiting
Phase 1Phase 2
A Phase 1/2 Study of VX-670 in Adult Participants With Myotonic Dystrophy 1 (DM1)
Myotonic Dystrophy Type 1 (DM1)
Vertex Pharmaceuticals Incorporated44 enrolled26 locationsNCT06185764
Recruiting
Phase 1
Acute Effects of Oral Nicotine Pouches
Nicotine Pouch Self-AdministrationNicotine Pharmacokinetic StudyNicotine Pharmacodynamic Study
Johns Hopkins University120 enrolled1 locationNCT07128329
Recruiting
Phase 1
A Trial to Investigate the Safety and Pharmacokinetics of GRT6019 in Healthy Male Participants
Duchenne Muscular Dystrophy (DMD)
Grünenthal GmbH24 enrolled1 locationNCT07347548
Recruiting
Phase 1Phase 2
Phase 1 Trial of Arginine Hydrochloride for the Management of Diabetic Ketoacidosis in Type 2 Diabetes
Diabetes (DM)Diabetic KetoacidosisKetosis Prone Diabetes+1 more
David K Carroll60 enrolled1 locationNCT07167693
Recruiting
Phase 1
Role of Alpha-to-beta Cell Communication to Adapt Insulin Secretion to Insulin Resistance.
Diabetes (DM)
David D'Alessio, M.D.30 enrolled1 locationNCT07224334