Phase 1 Dysfunction Clinical Trials
33 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 33 trials
Recruiting
Phase 1
Evaluating the Pharmacokinetics and Safety of Miricorilant
Nonalcoholic Steatohepatitis (NASH)Non-alcoholic Fatty Liver Disease NAFLDMetabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis+1 more
Corcept Therapeutics15 enrolled1 locationNCT07553663
Recruiting
Phase 1
A Study of Lepodisiran (LY3819469) in Participants With Normal, Mild, Moderate, or Severe Liver Function
HealthyLiver Dysfunction
Eli Lilly and Company33 enrolled4 locationsNCT06916078
Recruiting
Phase 1Phase 2
Study of TGM-312-SC01 in Healthy Participants and Adults With MASH
Healthy ParticipantsMASH - Metabolic Dysfunction-Associated Steatohepatitis
Tangram Therapeutics Plc99 enrolled1 locationNCT07427680
Recruiting
Phase 1Phase 2
Enhancing Parasympathetic Activity to Improve Endothelial Dysfunction, Vascular Oxidative Stress in African Americans
Endothelial Dysfunction
Vanderbilt University Medical Center160 enrolled1 locationNCT04769206
Recruiting
Phase 1Phase 2
Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
Hypoxia, BrainBlood PressureStroke+5 more
University of Calgary12 enrolled1 locationNCT03255408
Recruiting
Phase 1Phase 2
A Study to Evaluate ALN-CIDEB in Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease or With Metabolic Dysfunction-Associated Steatohepatitis (MASLD/MASH)
Metabolic Dysfunction-Associated Steatotic Liver DiseaseMetabolic Dysfunction-Associated Steatohepatitis
Regeneron Pharmaceuticals132 enrolled3 locationsNCT06836609
Recruiting
Phase 1
Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease
Cognitive ImpairmentSickle Cell DiseaseAttention Deficit Hyperactivity Disorder (ADHD)+1 more
St. Jude Children's Research Hospital72 enrolled1 locationNCT07226219
Recruiting
Phase 1Phase 2
Stem Cell Therapy for Early Alzheimer's Disease
Cognitive Dysfunction
Paul E Schulz12 enrolled1 locationNCT06775964
Recruiting
Phase 1Phase 2
A Trial to Learn if ALN-PNP is Safe and Well Tolerated in Healthy Adults and Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Healthy VolunteersMetabolic dysfunction–associated steatotic liver disease (MASLD)
Regeneron Pharmaceuticals172 enrolled6 locationsNCT05648214
Recruiting
Phase 1
Developing Microbial Therapy for MASLD: From Mechanism to Clinical Validation
Metabolic Dysfunction-Associated Steatotic Liver Disease
Leeuwenhoek Laboratories Co. Ltd.40 enrolled1 locationNCT07488975
Recruiting
Phase 1Phase 2
TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVD
Endothelial DysfunctionAtherosclerotic Cardiovascular Diseases
Hudson Biotech80 enrolled1 locationNCT07487363
Recruiting
Phase 1Phase 2
Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan
Heart FailureHeart Dysfunction
Virginia Commonwealth University53 enrolled1 locationNCT05194111
Recruiting
Phase 1Phase 2
Effect of a Daily Supplement on Plasma PAI-1 Levels
Endothelial DysfunctionAgingsenescence
University of California, Los Angeles35 enrolled2 locationsNCT07469475
Recruiting
Phase 1Phase 2
Effects of Vagal Dysfunction on Gastrointestinal and Inflammatory Pathways in HIV
HIVNon-HIVVagus Nerve Dysfunction
Icahn School of Medicine at Mount Sinai207 enrolled1 locationNCT04353778
Recruiting
Phase 1
Evaluation of Miricorilant on Liver Fat in Patients With MASLD
Nonalcoholic Steatohepatitis (NASH)Metabolic dysfunction-associated steatohepatitis (MASH)Non-alcoholic Fatty Liver Disease NAFLD+1 more
Corcept Therapeutics8 enrolled1 locationNCT06947304
Recruiting
Phase 1
ECC4703 Food Effect and Relative Bioavailability Study in Healthy Adult Participants
Metabolic Dysfunction-Associated Steatohepatitis
Eccogene72 enrolled1 locationNCT07334080
Recruiting
Phase 1
Vardenafil Nasal Spray in healthy volunteers including over 65's (15 days confinement in Sydney)
Erectile Dysfunction (ED)
LTR Pharma Ltd27 enrolled1 locationACTRN12626000048381
Recruiting
Phase 1
PVEK Corneal Implant For Treatment of Corneal Edema
Pseudophakic Bullous KeratopathyFuchs' Endothelial DystrophyCorneal Edema+1 more
Precise Bio15 enrolled3 locationsNCT07325097
Recruiting
Phase 1
Study to Assess Safety and Tolerability of Multiple Doses of EO2002
Endothelial DysfunctionPseudophakic Bullous KeratopathyFuchs' Endothelial Dystrophy+5 more
Asociación para Evitar la Ceguera en México12 enrolled1 locationNCT05636579
Recruiting
Phase 1
The Objective of This Phase 1 Study is to Evaluate the Food Effect of 100 mg Hezkue Turbo® (ASP-001.1, Sildenafil) Under Fed Versus 100 mg of Hezkue Turbo® (ASP-001.1, Sildenafil) Under Fasted Conditions in Healthy Adult Male Subjects
Erectile Dysfunction
Aspargo Labs, Inc12 enrolled1 locationNCT06872866