Early Phase 1 ESS Clinical Trials
50 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 50 trials
Recruiting
Early Phase 1
A Single Dose, Dose Escalation Clinical Trial on the Safety, Tolerability and Efficacy of Lyophilized Powder for Inhalation of Recombinant Human Keratinocyte Growth Factor-2 (Rh-KGF-2) in The Treatment of Patients With Acute Respiratory Distress Syndrome
ARDS (Moderate or Severe)ARDS (Acute Respiratory Distress Syndrome)
Shanghai Zhongshan Hospital24 enrolled1 locationNCT07558538
Recruiting
Early Phase 1
Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia
DementiaAlzheimer DiseaseProgressive Aphasia+3 more
University of Texas at Austin120 enrolled1 locationNCT06511752
Recruiting
Early Phase 1
Regulation of Brain Glucose Metabolism in Type 1 Diabetes
Diabetes Mellitus, Type 1Hypoglycemia Unawareness
Yale University16 enrolled1 locationNCT05317455
Recruiting
Early Phase 1
Tolerance Through Mixed Chimerism (Sip-Tego)
Kidney FailureTransplant Recipient (Kidney)Immunosuppresion+2 more
Tatsuo Kawai, MD, PhD12 enrolled1 locationNCT06972069
Recruiting
Early Phase 1
Autonomic Control of the Circulation and VDR
Blood PressureVenous Distension Reflex
Milton S. Hershey Medical Center18 enrolled1 locationNCT03513770
Recruiting
Early Phase 1
Glutamatergic Adaptation to Stress as a Mechanism for Anhedonia and Treatment Response With Ketamine
Major Depressive Disorder
Emory University140 enrolled1 locationNCT05327699
Recruiting
Early Phase 1
iNO300 Therapy in Critically Ill Patients With Pneumonia
PneumoniaCritical Illness
Massachusetts General Hospital34 enrolled1 locationNCT06950294
Recruiting
Early Phase 1
Open Label Study for the Use of Low Intensity Focused Ultrasound for Essential Tremor
Essential Tremor
University of California, Los Angeles20 enrolled1 locationNCT07599592
Recruiting
Early Phase 1
Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease
HypopituitarismArginine vasopressin deficiencyOxytocin Deficiency+1 more
Massachusetts General Hospital20 enrolled1 locationNCT07568509
Recruiting
Early Phase 1
Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression
Major Depression
Mclean Hospital80 enrolled1 locationNCT07560878
Recruiting
Early Phase 1
Pilot Study of [68Ga]Ga-ABY-025 Imaging in Patients Undergoing Treatment With HER2-targeted Therapy
Metastatic CancerHER2Locally Advanced Cancer+2 more
Vanderbilt-Ingram Cancer Center30 enrolled1 locationNCT06828588
Recruiting
Early Phase 1
Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
Alzheimer DiseaseMild Cognitive ImpairmentLogopenic Progressive Aphasia+1 more
Massachusetts General Hospital30 enrolled1 locationNCT06538311
Recruiting
Early Phase 1
Mental Health in Veterans and Families After Group Therapies
Post-Traumatic Stress Disorders
Soul Medicine Institute100 enrolled1 locationNCT01327690
Recruiting
Early Phase 1
Personalized DBS Targeting for Treating Depression
Treatment Resistant Depression (TRD)
Second Affiliated Hospital, School of Medicine, Zhejiang University5 enrolled1 locationNCT06784388
Recruiting
Early Phase 1
Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine
Major Depressive Disorder (MDD)
University of Pennsylvania10 enrolled1 locationNCT06788249
Recruiting
Early Phase 1
A Study of Niacin Regulation
Excessive Weight Gain
Mayo Clinic32 enrolled1 locationNCT06175403
Recruiting
Early Phase 1
Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm
Blood Pressure DisordersSalt; Excess
Wake Forest University Health Sciences120 enrolled1 locationNCT04026776
Recruiting
Early Phase 1
Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
DepressionDepressive SymptomsAlzheimer Disease+1 more
Johns Hopkins University20 enrolled1 locationNCT04123314
Recruiting
Early Phase 1
A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression
DepressionKnee Osteoarthritis
University of California, Los Angeles30 enrolled1 locationNCT06906939
Recruiting
Early Phase 1
Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma
Recurrent GlioblastomaProgressive Glioblastoma
Mayo Clinic8 enrolled1 locationNCT07076472