Early Phase 1 ESS Clinical Trials
43 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 43 trials
Recruiting
Early Phase 1
Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression
Major Depression
Mclean Hospital80 enrolled1 locationNCT07560878
Recruiting
Early Phase 1
Mental Health in Veterans and Families After Group Therapies
Post-Traumatic Stress Disorders
Soul Medicine Institute100 enrolled1 locationNCT01327690
Recruiting
Early Phase 1
Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine
Major Depressive Disorder (MDD)
University of Pennsylvania10 enrolled1 locationNCT06788249
Recruiting
Early Phase 1
A Study of Niacin Regulation
Excessive Weight Gain
Mayo Clinic32 enrolled1 locationNCT06175403
Recruiting
Early Phase 1
Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm
Blood Pressure DisordersSalt; Excess
Wake Forest University Health Sciences120 enrolled1 locationNCT04026776
Recruiting
Early Phase 1
Psilocybin for Depression in People With Mild Cognitive Impairment or Early Alzheimer's Disease
DepressionDepressive SymptomsAlzheimer Disease+1 more
Johns Hopkins University20 enrolled1 locationNCT04123314
Recruiting
Early Phase 1
A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression
DepressionKnee Osteoarthritis
University of California, Los Angeles30 enrolled1 locationNCT06906939
Recruiting
Early Phase 1
iNO300 Therapy in Critically Ill Patients With Pneumonia
PneumoniaCritical Illness
Massachusetts General Hospital34 enrolled1 locationNCT06950294
Recruiting
Early Phase 1
Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma
Recurrent GlioblastomaProgressive Glioblastoma
Mayo Clinic8 enrolled1 locationNCT07076472
Recruiting
Early Phase 1
Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
Alzheimer DiseaseMild Cognitive ImpairmentLogopenic Progressive Aphasia+1 more
Massachusetts General Hospital30 enrolled1 locationNCT06538311
Recruiting
Early Phase 1
First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the Brain
Healthy ParticipantsProgressive Supranuclear Palsy (PSP)
Invicro24 enrolled1 locationNCT07348276
Recruiting
Early Phase 1
An Open and Dose-escalation Early Clinical Study of CD19 and CD20 CAR-T Cell Therapy for Relapsed or Refractory Aggressive B-cell Lymphoma
R/R Aggressive B-cell Lymphoma
Peking University People's Hospital18 enrolled1 locationNCT07344818
Recruiting
Early Phase 1
Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study
DepressionEsketamineAdolescent+1 more
Min Su220 enrolled2 locationsNCT07247968
Recruiting
Early Phase 1
Metformin and Muscle Recovery
Muscle Atrophy or Weakness
University of Utah50 enrolled1 locationNCT06185179
Recruiting
Early Phase 1
Integrating Inuit Knowledge Principles in Multi-Level Mental Health Clinical Trials
Depression, Anxiety
University of Alberta40 enrolled2 locationsNCT07014852
Recruiting
Early Phase 1
REstoring CONsciousness With NEurostimulation of the Central Thalamus: The RECONNECT Study
Disorders of Consciousness
Samuel Snider, MD2 enrolled1 locationNCT07228286
Recruiting
Early Phase 1
Cognitive Behavioral Therapy and Trazodone Effects on Sleep and Blood Pressure in Insomnia
Blood Pressure, HighInsomniaBlood Pressure+2 more
Milton S. Hershey Medical Center600 enrolled4 locationsNCT06281756
Recruiting
Early Phase 1
Effects of Psilocybin in Obsessive Compulsive Disorder
Obsessive-Compulsive Disorder
Johns Hopkins University30 enrolled1 locationNCT05546658
Recruiting
Early Phase 1
Piloting Virtual Reality Environments to Treat PTSD in Healthcare Workers
Posttraumatic Stress Disorder
Weill Medical College of Cornell University20 enrolled1 locationNCT04887116
Recruiting
Early Phase 1
Tolerance Through Mixed Chimerism (Sip-Tego)
Kidney FailureTransplant Recipient (Kidney)Immunosuppresion+2 more
Tatsuo Kawai, MD, PhD12 enrolled1 locationNCT06972069