Phase 2 ESS Clinical Trials
576 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 576 trials
Recruiting
Phase 2
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
DepressionDepressive DisorderMolecular Mechanisms of Pharmacological Action+10 more
National Institute of Mental Health (NIMH)50 enrolled1 locationNCT06511908
Recruiting
Phase 2
A Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)
Chronic respiratory failureNon-invasive ventilationRespiratory Insufficiency+7 more
University of Pennsylvania48 enrolled3 locationsNCT07071935
Recruiting
Phase 2
Neurobiology of Suicide
DepressionHealthy Volunteers
National Institute of Mental Health (NIMH)325 enrolled1 locationNCT02543983
Recruiting
Phase 2
Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV
Mild Neurocognitive DisorderMajor Depressive DisorderHIV
National Institute of Allergy and Infectious Diseases (NIAID)186 enrolled41 locationsNCT06705478
Recruiting
Phase 2
Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)
InfectionsAcute Respiratory Distress Syndrome
BioAegis Therapeutics Inc.600 enrolled70 locationsNCT05947955
Recruiting
Phase 1Phase 2
211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome
Hematopoietic and Lymphoid Cell NeoplasmAcute Myeloid Leukemia in RemissionChronic Myelomonocytic Leukemia+9 more
Fred Hutchinson Cancer Center30 enrolled1 locationNCT03670966
Recruiting
Phase 2
Efficacy and Safety of Sertraline Combined With Lactobacillus Crispatus in Adolescents With Depression
Major Depressive Disorder (MDD)Probiotic Intervention
First Affiliated Hospital of Chongqing Medical University60 enrolled2 locationsNCT07539805
Recruiting
Phase 2
A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder
Major Depressive Disorder
AbbVie195 enrolled33 locationsNCT07276997
Recruiting
Phase 2
Exogenous Ketone Supplementation in ICU Delirium
ICU deliriumCritical Illness
Vanderbilt University Medical Center40 enrolled1 locationNCT07364162
Recruiting
Phase 2
A Phase 2 Study to Assess STP938 as a Monotherapy in Adults With High Risk Essential Thrombocythaemia - The VECTRA Trial
Essential Thrombocythaemia
Step Pharma, SAS50 enrolled14 locationsNCT06786234
Recruiting
Phase 2
Intravenous Brincidofovir as an Antiviral for Treatment of Progressive Multifocal Leukoencephalopathy: A Pilot Study
Progressive Multifocal Leukoencephalopathy
National Institute of Neurological Disorders and Stroke (NINDS)24 enrolled1 locationNCT07511049
Recruiting
Phase 2
Cannabidiol and Older Adult Cannabis Users
PainDepressionSleep+1 more
University of Colorado, Boulder385 enrolled1 locationNCT06290063
Recruiting
Phase 2Phase 3
A Randomized Phase II Basket Trial EXTENDing Efficacy of Systemic Therapy With Local Consolidative Therapy for OligoProgressive Metastatic Disease (EXTEND-OP)
OligoProgressive Metastatic Disease
M.D. Anderson Cancer Center400 enrolled1 locationNCT06367972
Recruiting
Phase 1Phase 2
Clinical Trial of YH32364 in Patients With Locally Advanced or Metastatic EGFR Overexpressing Solid Tumors
Metastatic Solid TumorLocally Advanced Solid TumorEGFR Overexpression
Yuhan Corporation80 enrolled4 locationsNCT06975410
Recruiting
Phase 2
Sertraline Combined With Multi-Strain Probiotics for Adolescent Depression
Major Depressive Disorder (MDD)Probiotic Intervention
First Affiliated Hospital of Chongqing Medical University120 enrolled1 locationNCT07645157
Recruiting
Phase 2
Mindfulness-based Psilocybin Therapy for PTSD
Depression - Major Depressive DisorderPost Traumatic Stress Disorder
Anthony P King30 enrolled1 locationNCT07104916
Recruiting
Phase 2Phase 3
Evaluating Smoking Cessation Interventions for PWH in South Africa
Comorbidities and Coexisting ConditionsSmoking CessationHIV
Johns Hopkins University660 enrolled1 locationNCT05413122
Recruiting
Phase 2
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
Major Depressive Disorder (MDD)Depressive Disorder, Treatment-Resistant
ACADIA Pharmaceuticals Inc.153 enrolled21 locationsNCT07284667
Recruiting
Phase 2
A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors
Breast CancerColorectal, CancerEsophageal Cancer+9 more
Jazz Pharmaceuticals200 enrolled28 locationsNCT06695845
Recruiting
Phase 1Phase 2
Study on Safety and Efficacy of Two Doses of PRS CK STORM in the Modulation of the Cytokine Storm in Patients With Acute Respiratory Infection Caused by SARS-Cov-2, Influenza A, Influenza B and Respiratory Syncytial Virus (RSV)
Systemic Inflammatory Response SyndromeSARS CoV-2Respiratory distress syndrome+2 more
PEACHES BIOTECH50 enrolled3 locationsNCT06684379