Facial Pain Clinical Trials

17 recruitingLast updated: May 13, 2026

There are 17 actively recruiting facial pain clinical trials across 9 countries. Studies span Not Applicable, Phase 4, Phase 2. Top locations include Milan, Italy, Baghdad, Iraq, Banī Suwayf, Egypt. Updated daily from ClinicalTrials.gov.


Facial Pain Trials at a Glance

17 actively recruiting trials for facial pain are listed on ClinicalTrialsFinder across 6 cities in 9 countries. The largest study group is Not Applicable with 11 trials, with the heaviest enrollment activity in Milan, Baghdad, and Banī Suwayf. Lead sponsors running facial pain studies include Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Donald Nixdorf, and Ankara Etlik City Hospital.

Browse facial pain trials by phase

Treatments under study

About Facial Pain Clinical Trials

Looking for clinical trials for Facial Pain? There are currently 2 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Facial Pain trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Facial Pain clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 117 of 17 trials

Recruiting
Not Applicable

Effect of Occlusal Splint on Head and Neck Muscles in Patients With Bruxism and Myofascial Pain

masticatory muscle pain,BruxismMyofacial Pain Syndrome+1 more
Istanbul University40 enrolled1 locationNCT07090551
Recruiting
Phase 2

Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial Pain

MigraineCluster HeadacheCraniofacial Pain+3 more
Stanford University15 enrolled1 locationNCT04930887
Recruiting

Neurosurgical Outcome Network

DepressionTrigeminal NeuralgiaObsessive-Compulsive Disorder+20 more
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta4,500 enrolled27 locationsNCT06724029
Recruiting
Not Applicable

Comparing the Effectiveness of Online vs. Face-to-face Physiotherapy for Treating Temporomandibular Disorders

Temporomandibular disorder (TMD)Temporomandibular Disorders (TMD)TMD/Orofacial Pain+4 more
Semmelweis University90 enrolled2 locationsNCT07474662
Recruiting
Not Applicable

An Innovative Cognitive-Behavioral Treatment For Chronic Orofacial Pain

Chronic Primary Orofacial Pain (CPOP)Persistent Idiopathic Facial Pain (PIFP)
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta60 enrolled1 locationNCT07123233
Recruiting
Not Applicable

Reflex Therapy of Temporomandibular Dysfunctions

Temporomandibular Joint Dysfunction; Myofascial Pain Syndrome; Orofacial Pain; Musculoskeletal Disorders
Palacky University100 enrolled1 locationNCT07321483
Recruiting
Not Applicable

Treatment Validation for Myofascial Pain

Chronic Low Back Pain (CLBP)myofacial pain
Ajay Wasan, MD, Msc80 enrolled1 locationNCT07133139
Recruiting
Not Applicable

Effects Exercises in Temporomandibular Joint Disorders on Pain, Joint and Tongue Functions

TMDTMD/Orofacial Pain
Tayfun ISIK48 enrolled1 locationNCT07304557
Recruiting
Not Applicable

Orofacial Pain Self-management: Personality Moderation Effect

Temporomandibular disorder (TMD)Temporomandibular Disorders (TMD)Chronic Orofacial Pain+1 more
Fundación Universidad Católica de Valencia San Vicente Mártir98 enrolled1 locationNCT06932406
Recruiting
Not Applicable

Feasibility Testing of the "Face-Forward-Web" Program for Chronic Orofacial Pain

Orofacial PainFacial Pain
Massachusetts General Hospital30 enrolled1 locationNCT06754917
Recruiting
Phase 4

Effectiveness of Chlorzoxazone Versus Orphenadrine Citrate in Alleviating Bruxism Pain

BruxismOrofacial Pain
University of Baghdad60 enrolled1 locationNCT07109882
Recruiting
Not Applicable

Efficacy of Adding Greater Occipital Nerve Block to Trigger Point Injection in Patients With Neck Pain

Trigger pointsCervicogenic headacheNeck Pain+3 more
Ankara Etlik City Hospital60 enrolled1 locationNCT07058636
Recruiting

Exploration of the Utility of Dental-dedicated MRI for Dentistry

orthodonticsDental CrowdingEndodontic Disease+5 more
Donald Nixdorf300 enrolled1 locationNCT06948162
Recruiting
Not Applicable

KT vs IASTM on Upper Trapezius Myofascial Trigger Points To Compare Effect of KT VS IASTM on Pain Intensity, Pain Pressure Threshold, Cervical Range of Motion and Functional Disability Level.

Myofacial Pain Syndromes
Reham Sayed Mesaed50 enrolled1 locationNCT06899685
Recruiting
Not Applicable

Manual Therapy Effectivity and Exercises in Musicians

Orofacial Pain
Prof. Dr. Daniel Pecos Martín40 enrolled2 locationsNCT04977349
Recruiting

Emotion and Memory in Chronic Neuropathic Pain

Trigeminal NeuralgiaFacial Pain
University Health Network, Toronto400 enrolled1 locationNCT06518421
Recruiting
Phase 4

Trigger Point Injections in Anterior Cervical Surgery

myofacial painPain, BackCervical Fusion+1 more
George Washington University60 enrolled1 locationNCT04640896