Trigeminal Neuralgia Clinical Trials

18 recruiting

Trigeminal Neuralgia Trials at a Glance

22 actively recruiting trials for trigeminal neuralgia are listed on ClinicalTrialsFinder across 6 cities in 12 countries. The largest study group is Not Applicable with 9 trials, with the heaviest enrollment activity in Zagazig, Monaco, and Minneapolis. Lead sponsors running trigeminal neuralgia studies include University of Minnesota, Beijing Tiantan Hospital, and Zagazig University.

Browse trigeminal neuralgia trials by phase

Treatments under study

About Trigeminal Neuralgia Clinical Trials

Looking for clinical trials for Trigeminal Neuralgia? There are currently 18 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Trigeminal Neuralgia trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Trigeminal Neuralgia clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 22 trials

Recruiting
Phase 2

Ultra-Early Gamma Knife Stereotactic Radiosurgery for TN

Trigeminal Neuralgia (TN)
University of Alberta80 enrolled2 locationsNCT06949436
Recruiting

Neurosurgical Outcome Network

Trigeminal NeuralgiaHydrocephalusSubarachnoid Hemorrhage+14 more
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta4,500 enrolled27 locationsNCT06724029
Recruiting

The Will Erwin Headache Research Center - Cluster Headache Study

Trigeminal NeuralgiaCluster HeadacheCluster Headaches and Other Trigeminal Autonomic Cephalgias+3 more
The University of Texas Health Science Center, Houston1,500 enrolled1 locationNCT02910323
Recruiting
Phase 4

OnabotulinumtoxinA for Trigeminal Neuralgia

Trigeminal Neuralgia
Stanford University20 enrolled1 locationNCT06216886
Recruiting
Early Phase 1

Trigeminal Evoked Responses to Improve Rhizotomy

Trigeminal NeuralgiaRhizotomy
University of Minnesota30 enrolled1 locationNCT05738096
Recruiting

Trigeminal Neuralgia Electrophysiology

Trigeminal Neuralgia
University of Minnesota30 enrolled1 locationNCT05269472
Recruiting
Not Applicable

A Study to Investigate the Efficacy of Pain Reduction With Cryoneurolysis Compared With Sham-treatment in Adults With Trigeminal Neuralgia

Trigeminal Neuralgia
St. Olavs Hospital24 enrolled1 locationNCT06213155
Recruiting
Not Applicable

Assessment in Patients With Essential Trigeminal Neuralgia of Nerve Involvement by MRI in DTI and Functional Connectivity in "Resting State"

Trigeminal NeuralgiaDiffusion Tensor ImagingMicrovascular Decompression Surgery
Fondation Ophtalmologique Adolphe de Rothschild60 enrolled1 locationNCT05051072
Recruiting

Intravenous Lacosamide for the Treatment of Acute Pain in Trigeminal Neuralgia

Trigeminal Neuralgia
Hospital Universitari de Bellvitge20 enrolled1 locationNCT06851910
Recruiting
Not Applicable

Esketamine Combined Pulsed Radiofrequency for Acute/Subacute Zoster-associated Trigeminal Neuralgia

Zoster; Herpes, Trigeminal Neuralgia (Etiology)
Beijing Tiantan Hospital174 enrolled1 locationNCT06890897
Recruiting
Phase 1

Safety of Cultured Allogeneic Adult Umbilical Cord Stem Cells Exosomes for Trigeminal Neuralgia

Peripheral NeuropathyTrigeminal Neuralgia
The Foundation for Orthopaedics and Regenerative Medicine20 enrolled1 locationNCT05152368
Recruiting
Not Applicable

Impact of Individual Radiosensitivity on Late Toxicities of Radiosurgery in Essential Trigeminal Neuralgia

Trigeminal Neuralgia Treated by Radiosurgery
Centre Hospitalier Universitaire de Nice74 enrolled2 locationsNCT06863324
Recruiting

The Efficacy and Safety of Pulsed Radiofrequency Combined With Platelet-rich Plasma for the Trigeminal Neuralgia

PRPTrigeminal Neuralgia, Idiopathic
Beijing Tiantan Hospital270 enrolled1 locationNCT06472323
Recruiting
Not Applicable

Masseter Muscle Thickness in Gasser Ganglion Radiofrequency Treatment

Trigeminal NeuralgiaGasserian Ganglion; Lesion
Başakşehir Çam & Sakura City Hospital30 enrolled1 locationNCT06278194
Recruiting

Observational Study on the Treatment of Trigeminal Neuralgia by Radiosurgery

Trigeminal Neuralgia
Centre Hospitalier Princesse Grace150 enrolled1 locationNCT05677243
Recruiting
Not Applicable

Fluoroscopic-Guided Bipolar Versus Monopolar Pulsed Radiofrequency for Refractory Trigeminal Neuralgia

Trigeminal NeuralgiaRefractory Pain
Alexandria University20 enrolled2 locationsNCT06779578
Recruiting
Not Applicable

Comparison of Pulsed and Thermal Radiofrequency for Trigeminal Neuralgia

Trigeminal Neuralgia
Zagazig University60 enrolled1 locationNCT06684275
Recruiting
Phase 1

Deep Brain Stimulation for Refractory Trigeminal Neuralgia with a Pontine Lesion

Trigeminal Neuralgia
Université de Sherbrooke6 enrolled1 locationNCT05451251
Recruiting
Not Applicable

CT-guided vs Fluoroscopy-guided Trigeminal Ganglion Radiofrequency Thermocoagulation for Idiopathic Trigeminal Neuralgia

Trigeminal NeuralgiaTrigeminal Neuralgia, Idiopathic
Zagazig University60 enrolled1 locationNCT06620172
Recruiting

RSSearch Patient Registry-Long Term Study of Use of SRS/SBRT

NeoplasmsArteriovenous Malformation of Central Nervous SystemTrigeminal Neuralgia
The Radiosurgery Society50,000 enrolled13 locationsNCT01885299