Phase 1 Gliomas Clinical Trials
11 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–11 of 11 trials
Recruiting
Phase 1
[212Pb]VMT-Alpha-NET in Metastatic or Inoperable Somatostatin-Receptor Positive Gastrointestinal Neuroendocrine Tumors, Pheochromocytoma/Paragangliomas, Small Cell Lung, Renal Cell, and Head and Neck Cancers
Kidney CancersHead and Neck TumorsSmall Cell Lung Cancers+3 more
National Cancer Institute (NCI)120 enrolled1 locationNCT06479811
Recruiting
Phase 1
Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma
GlioblastomaMalignant GliomaRecurrent Glioblastoma+2 more
Beijing Biotech36 enrolled1 locationNCT07551336
Recruiting
Phase 1Phase 2
Somatostatin-Receptors (SSTR)-Agonist [212Pb]VMT-alpha-NET in Metastatic or Inoperable SSTR+ Gastrointestinal Neuroendocrine Tumor and Pheochromocytoma/Paraganglioma Previously Treated With Systemic Targeted Radioligand Therapy
PheochromocytomaGastrointestinal Neuroendocrine TumorsSomatostatin Receptor Positive+1 more
National Cancer Institute (NCI)66 enrolled1 locationNCT06427798
Recruiting
Phase 1
A Study of Avutometinib for People With Solid Tumor Cancers
Solid TumorSolid Tumor, AdultNeuroblastoma+12 more
Memorial Sloan Kettering Cancer Center23 enrolled2 locationsNCT06104488
Recruiting
Phase 1Phase 2
5G-PEARL: Paxalisib in Malignant Brain Tumours
Glioblastoma Multiforme (GBM)Malignant Primary Gliomas
Institute of Cancer Research, United Kingdom64 enrolled1 locationNCT07391215
Recruiting
Phase 1Phase 2
5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours
Glioblastoma Multiforme (GBM)Malignant Primary GliomasGlioblastoma Multiform (Grade IV Astrocytoma)+1 more
Institute of Cancer Research, United Kingdom182 enrolled3 locationsNCT06630260
Recruiting
Phase 1Phase 2
Clinical Study on the Treatment of Malignant Brain Glioma by QH104 Cell Injection
GBMHigh-Grade GliomasBrain Gliomas
Dushu Lake Hospital Affiliated to Soochow University25 enrolled1 locationNCT06018363
Recruiting
Phase 1
Phase I Study of HMPL-306 for the Treatment of Gliomas With IDH1 and/or IDH2 Mutations
Gliomas Harboring IDH1 and/or IDH2 Mutations
Hutchmed52 enrolled1 locationNCT07025018
Recruiting
Phase 1
5G-EMERALD: Amivantamab in Malignant Brain Tumours
Glioblastoma Multiforme (GBM)Malignant Primary GliomasGlioblastoma Multiform (Grade IV Astrocytoma)+1 more
Institute of Cancer Research, United Kingdom12 enrolled2 locationsNCT06632236
Recruiting
Phase 1
Safety and Efficacy Study for DC Vaccine in Recurrent or Progressive High-grade Gliomas
WHO Grade III GliomasWHO Grade IV Gliomas
Beijing Tiantan Hospital12 enrolled1 locationNCT06253234
Recruiting
Phase 1Phase 2
TIL Therapy Combined With Pembrolizumab for Advanced Brain Cancer Including Gliomas and Meningiomas
Brain MetastasesBrain TumorBrain Cancer+4 more
Essen Biotech85 enrolled1 locationNCT06640582