Phase 1 Heart Disease Clinical Trials
15 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–15 of 15 trials
Recruiting
Phase 1Phase 2
Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children
Mechanical VentilationCongenital Heart DiseaseChildren+8 more
Charite University, Berlin, Germany80 enrolled1 locationNCT07193719
Recruiting
Phase 1
A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease
Premature Coronary Heart DiseaseHeterozygous Familial Hypercholesterolemia
Verve Therapeutics, Inc.85 enrolled22 locationsNCT06164730
Recruiting
Phase 1Phase 2
A Study on Yiyang Huoluo Decoction in the Treatment of Coronary Heart Disease
Coronary Heart DiseaseCoronary Artery DiseaseAtheroscleroses
Xia Liang30 enrolled1 locationNCT07493603
Recruiting
Phase 1
Autologous Induced Pluripotent Stem Cells of Cardiac Lineage for Congenital Heart Disease
Congenital Heart DiseaseHeart Failure NYHA Class IIIHeart Failure NYHA Class IV+1 more
HeartWorks, Inc.50 enrolled1 locationNCT05647213
Recruiting
Phase 1Phase 2
Propranolol Treatment for Postoperative Chylothorax
Congenital Heart DiseasePostoperative Chylothorax
June Wu50 enrolled1 locationNCT06833320
Not Yet Recruiting
Phase 1
A study to compare safety, tolerability, and how the body processes a powdered penicillin injection (Extencilline®) given into the muscle or under the skin in healthy adults
Group A streptococcal infectionsRheumatic heart diseaseSyphilis
The Kids Research Institute Australia15 enrolled1 locationACTRN12625000684426
Completed
Phase 1
Subcutaneous infusions of benzathine penicillin G (SCIP) in healthy adults
Streptococcus pyogenes infectionRheumatic heart disease
Telethon Kids Institute24 enrolled1 locationACTRN12621000135819
Completed
Phase 1
A Dose-Escalation Safety Study of Yindan Softgels in Healthy Subjects
ischemic stroke sequelaeunstable angina pectoris of coronary heart disease (CHD)
Axeon Research (Au) Pty Ltd.40 enrolled1 locationACTRN12618000582257
Completed
Phase 1
Drug-Eluting Stent Study Evaluating a New Technology in Patients with Symptomatic Ischemic Heart Disease due to Coronary Artery Blockage
Symptomatic Ischemic Heart DiseaseCoronary Artery Disease
Svelte Medical Systems, Inc.30 enrolled3 locationsACTRN12611001131943
Completed
Phase 1
To determine whether a pharmacokinetic drug-drug interaction occurs between atorvastatin and elinogrel.
chronic coronary heart disease (CHD)
Novartis Pharmaceutical Pty Limited28 enrolled1 locationACTRN12611000315910
Recruiting
Phase 1
Weight Management Program for People with Cardiac Disease and Diabetes
weight management in people with existing coronary heart disease and/or type 2 diabetes mellitus
University of Technology, Sydney168 enrolled1 locationACTRN12609000488202
Recruiting
Phase 1
The effect of remote ischaemic preconditioning on lowering postoperative myocardial troponin I release in children with congenital heart disease undergoing cardiopulmonary bypass.
Congenital heart disease witithin neonates
Michael Cheung68 enrolled1 locationACTRN12607000004460
Completed
Phase 1
Effects of regular consumption of lupin kernel flour-enriched foods on risk factors for heart disease
Risk factors for heart disease in overweight healthy subjects
Western Australia Department of Agricultural80 enrolled1 locationACTRN12606000034538
Active
Phase 1
The Role of non-GP Staff in Chronic Disease Management in General Practice.
Diabetes MellitusHypertensionIschemic Heart Disease
Centre for GP Integration Studies, University of New South Wales.3,000 enrolled1 locationACTRN12605000788673
Not Yet Recruiting
Phase 1
Angiogenesis II-Safety and feasibility of autologous mesenchymal precursor cells (MPCs) in chronic myocardial ischaemia.
End stage Ischaemic heart disease
Mesoblast10 enrolled1 locationACTRN12605000727640