Phase 2 Histiocytosis Clinical Trials
17 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–17 of 17 trials
Recruiting
Phase 2Phase 3
Open-label Study of ELA026 in Participants With Secondary Hemophagocytic Lymphohistiocytosis (sHLH)
Secondary Hemophagocytic Lymphohistiocytosis (sHLH)
Electra Therapeutics Inc.156 enrolled40 locationsNCT05416307
Recruiting
Phase 2
A Study With Tovorafenib (DAY101) as a Treatment Option for Progressive, Relapsed, or Refractory Langerhans Cell Histiocytosis
Recurrent Langerhans Cell HistiocytosisRefractory Langerhans Cell Histiocytosis
National Cancer Institute (NCI)48 enrolled117 locationsNCT05828069
Recruiting
Phase 2
Ruxolitinib as First Line Treatment in Primary Haemophagocytic Lymphohistiocytosis (R-HLH)
Haemophagocytic Lymphohistiocytosis
Assistance Publique - Hôpitaux de Paris20 enrolled1 locationNCT05762640
Recruiting
Phase 1Phase 2
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Non-small Cell Lung CancerMetastatic Lung CancerMetastatic Lung Non-Small Cell Carcinoma+18 more
Institut de Recherches Internationales Servier554 enrolled11 locationsNCT05786924
Recruiting
Phase 1Phase 2
Combination of Mitoxantrone Liposome and Etoposide, Dexamethasone, Pegaspargase and Golidocitinib (MEPL-G) in the Treatment of NK/T-cell Lymphoma Associated Hemophagocytic Lymphohistiocytosis (NKTCL-HLH)
Extranodal NK T Cell LymphomaHemophagocytic Lymphohistiocytosis (HLH)
Beijing Tongren Hospital25 enrolled1 locationNCT07525466
Recruiting
Phase 2
Targeted Approach to Langerhans Cell Histiocytosis (LCH) Using MEK Inhibitor, Trametinib
Langerhans Cell Histiocytosis
Cook Children's Health Care System75 enrolled1 locationNCT06582745
Recruiting
Phase 2
Optimization of the Time and Dosage of Vemurafenib in BRAF Positive Juvenile Patients With Refractory Histiocytosis
Histiocytosis
Anna Raciborska25 enrolled1 locationNCT04943198
Recruiting
Phase 2
Optimization of the Time and Dosage of Trametinib in BRAF Negative Juvenile Patients
Histiocytosis
Anna Raciborska12 enrolled1 locationNCT04943224
Recruiting
Phase 2Phase 3
Golidocitinib Combined With Selinexor for CAEBVD
EBVLymphohistiocytosisCAEBV
Beijing Friendship Hospital28 enrolled1 locationNCT07369739
Recruiting
Phase 2Phase 3
Prospective Single-Arm Clinical Trial of GO Regimen for HLH.
Lymphohistiocytosis, Hemophagocytic
Beijing Friendship Hospital28 enrolled1 locationNCT07339345
Recruiting
Phase 2
Efficacy and Safety of Low-Dose Cytarabine Combined With Thalidomide in Adult Patients With Untreated LCH
Langerhans Cell Histiocytosis
Cancer Institute and Hospital, Chinese Academy of Medical Sciences50 enrolled1 locationNCT07187193
Recruiting
Phase 2
Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders
Langerhan's Cell HistiocytosisJuvenile XanthogranulomaErdheim-Chester Disease+4 more
Carl Allen90 enrolled12 locationsNCT04079179
Recruiting
Phase 2
Mirdametinib in Histiocytic Disorders
Histiocytic DisordersRosai-Dorfman Disease (RDD)Langerhans Cell Histiocytosis (LCH)+1 more
Children's Hospital Medical Center, Cincinnati40 enrolled1 locationNCT06153173
Recruiting
Phase 2
Real-world Study of Darafenib or Trametinib and Clofarabine for High-risk/Recurrent/Refractory Langerhans Cell Histiocytosis in Children
Langerhans Cell Histiocytosis (LCH)
West China Second University Hospital20 enrolled1 locationNCT07022834
Recruiting
Phase 2Phase 3
LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis
Langerhans Cell Histiocytosis
North American Consortium for Histiocytosis1,400 enrolled42 locationsNCT02205762
Recruiting
Phase 2
To Evaluate the Efficacy, Safety, and PK Characteristics of FCN-159 in Pediatric Patients With Refractory/Recurrent LCH
Langerhans Cell HistiocytosisLCH
Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.56 enrolled11 locationsNCT05997602
Recruiting
Phase 2
Oral Prednisone in Treating LCH of Bone in Childhood and Adolescence
Langerhans Cell Histiocytosis of Bone
Shanghai Changzheng Hospital118 enrolled1 locationNCT06078969