Hot Flash Clinical Trials

19 recruitingLast updated: May 13, 2026

There are 19 actively recruiting hot flash clinical trials across 15 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 4. Top locations include Rochester, Minnesota, United States, Adelaide, Australia, Amsterdam, Netherlands. Updated daily from ClinicalTrials.gov.


Hot Flash Trials at a Glance

19 actively recruiting trials for hot flash are listed on ClinicalTrialsFinder across 6 cities in 15 countries. The largest study group is Not Applicable with 9 trials, with the heaviest enrollment activity in Rochester, Adelaide, and Amsterdam. Lead sponsors running hot flash studies include Mayo Clinic, Bespoke Clinical Research, and Astellas Pharma Global Development, Inc..

Browse hot flash trials by phase

Treatments under study

About Hot Flash Clinical Trials

Looking for clinical trials for Hot Flash? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Hot Flash trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Hot Flash clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 119 of 19 trials

Recruiting
Not Applicable

A Feasibility Study of Biometric Measurements Via Wearable Smart Watch Technology for Evaluation of Vasomotor Symptoms in Patients Treated With Androgen Deprivation Therapy for Prostate Cancer (Prostate 007)

Prostate CancerHot Flashes
University of Virginia18 enrolled1 locationNCT07535541
Recruiting

The Cardiovascular Impact of Hot Flushes

MenopauseHot Flashes
University of Minnesota60 enrolled1 locationNCT05251324
Recruiting
Phase 2Phase 3

Focusing on the Menopausal Transition to Improve Mid-Life Women's Health

MenopauseMenopause Related ConditionsCardiovascular+1 more
University of Colorado, Denver200 enrolled1 locationNCT06975111
Recruiting
Not Applicable

Improving Sympathetic Activity, Hot Flashes, and Sleep in Midlife Women Using Inspiratory Muscle Strength Training

MenopauseHot FlashesBlood Pressure Regulation
Mayo Clinic30 enrolled1 locationNCT06743269
Recruiting
Phase 4

The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity

ObesityMenopause Hot Flashes
Mayo Clinic40 enrolled1 locationNCT07218445
Recruiting
Phase 2

Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy

Prostate CancerProstate CarcinomaProstate Neoplasm+15 more
Shehzad Basaria, M.D.60 enrolled1 locationNCT06957691
Recruiting
Phase 2

Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients

Breast CancerHot Flashes
University of Arkansas110 enrolled1 locationNCT01530373
Recruiting
Phase 3

A Study to Confirm if Fezolinetant Helps Reduce Hot Flashes in Women With Breast Cancer Who Are Having Hormone Therapy

Hot Flashes
Astellas Pharma Global Development, Inc.540 enrolled117 locationsNCT06440967
Recruiting
Not Applicable

Men With Prostate Cancer: Optimizing Wellness by Enhanced Relief From Hot Flashes With Acupuncture

Hot FlashesVasomotor SymptomsAndrogen Deprivation Therapy+2 more
Inova Health Care Services24 enrolled1 locationNCT07335224
Recruiting
Not Applicable

JDS-HF3.0 Supplementation on Menopause Related Quality of Life Outcomes in Postmenopausal Women

Night SweatsHot FlashesJoint Pain+4 more
Bonafide Health250 enrolled1 locationNCT07238478
Recruiting

A Trial to Investigate the Accuracy of a Wearable Device in Collecting Data Related to Perimenopausal Symptoms in Women

PerimenopausePerimenopausal DepressionPerimenopausal Insomnia+5 more
IdentifyHer Limited110 enrolled1 locationNCT07022925
Recruiting
Not Applicable

Hot Flashes and Neurovascular Function in Women

MenopauseHot FlashesVasomotor System; Labile
Mayo Clinic120 enrolled1 locationNCT05193968
Recruiting
Not Applicable

Evaluation of the Beneficial Effects of a Product Containing Γ-aminobutyric Acid (GABA) on Climacteric Syndrome Disorders

Climacteric symptomsHot Flashes
Ospedale Policlinico San Martino112 enrolled1 locationNCT06864520
Recruiting
Phase 3

REDucing Hot FLASHes in Women Using Endocrine Therapy.

Breast CancerHot Flash Due to Medication
Reinier de Graaf Groep260 enrolled1 locationNCT06106529
Recruiting
Not Applicable

Strength and Aerobic Training Against Hot Flushes in Postmenopausal Women

Hot FlashesPostmenopausal Symptoms
Linkoeping University90 enrolled2 locationsNCT06030388
Recruiting
Not Applicable

Efficacy and Safety of Shatavari for Treatment of Menopausal Symptoms in Women: A Randomized, Double-blind, Three-arm, Parallel, Placebo-controlled Study

MenopauseHot FlashesMood
SF Research Institute, Inc.51 enrolled1 locationNCT06716554
Recruiting
Not Applicable

Reflexology Versus Acupressure on Sleep Disturbance and Hot Flashes

Hot FlashesPostmenopausal Flushing
Cairo University54 enrolled1 locationNCT06499311
Recruiting

Virtual perI-/Menopause Registry of AusTrALia

MenopauseHot FlashesCardiovascular Diseases+17 more
Bespoke Clinical Research10,000 enrolled1 locationNCT06487130
Recruiting

Natural Course of Hot Flash Symptoms in Men Receiving Androgen-Deprivation Therapy for Prostate Cancer – a Pilot Investigation.

Natural course of hot flashes in men with prostate cancer, receiving ADT for the first time.
A/Professor Henry Woo20 enrolled1 locationACTRN12613000566730