Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients

This study is comparing two medications — solifenacin (a bladder medication) and clonidine (a blood pressure medication) — to see which is more effective at reducing hot flashes in breast cancer patients who are taking hormone-blocking treatments like tamoxifen or aromatase inhibitors. **You may be eligible if...** - You have a history of invasive breast cancer or DCIS (an early-stage breast condition) - You are currently taking an aromatase inhibitor or tamoxifen - You have not used hormone replacement therapy for at least one month - You are 18 or older - You experience hot flashes at least 14 times per week and have had them for at least a month - If you take certain antidepressants or gabapentin, your dose has been stable for the past 4 weeks **You may NOT be eligible if...** - You are currently using hormone replacement therapy - You are not experiencing frequent hot flashes - You are not taking tamoxifen or an aromatase inhibitor - You have certain conditions or medications that would make the study drugs unsafe Talk to your doctor to see if this trial is right for you.