Phase 1 Impairment Clinical Trials
61 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 61 trials
Recruiting
Phase 1
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
HealthyMild Cognitive ImpairmentAlzheimer s Disease
National Institute of Mental Health (NIMH)90 enrolled1 locationNCT07169630
Recruiting
Phase 1
A Study to Assess the Safety and Pharmacokinetics of INCB123667 When Administered Orally to Adult Participants With Severe Renal Impairment or End Stage Renal Disease
Renal Impairment
Incyte Corporation16 enrolled2 locationsNCT07559396
Recruiting
Phase 1
A Study to Assess the Drug Levels and Safety of BMS-986435 in Participants With Normal Hepatic Function and Participants With Different Degrees of Hepatic Impairment
Healthy VolunteersHepatic Impairment
Bristol-Myers Squibb24 enrolled3 locationsNCT07248839
Recruiting
Phase 1
A Study to Test How BI 1291583 is Taken up in the Blood of People With and Without Liver Problems
HealthyHepatic Impairment
Boehringer Ingelheim32 enrolled3 locationsNCT07023354
Recruiting
Phase 1
Pharmacokinetics and Safety Study of Pelabresib in Patients With Advanced Malignancies and Hepatic Impairment
Advanced Malignancies and Hepatic Impairment
Novartis Pharmaceuticals24 enrolled5 locationsNCT07422610
Recruiting
Phase 1
A Study to Evaluate the Effect of Moderate or Severe Hepatic Impairment on the Pharmacokinetics (PK) of Inavolisib
Hepatic Impairment
Genentech, Inc.32 enrolled4 locationsNCT07144111
Recruiting
Phase 1
Pharmacokinetic Study of Vorasidenib in Severe Hepatically Impaired and Matched-Control Participants
Severe Hepatic ImpairmentNormal Hepatic Function
Institut de Recherches Internationales Servier (I.R.I.S.)20 enrolled3 locationsNCT07250633
Recruiting
Phase 1
A Phase I Study to Investigate the Effect of Hepatic Impairment of AZD9550 and AZD6234
Hepatic Impairment
AstraZeneca28 enrolled4 locationsNCT07546760
Recruiting
Phase 1
A Clinical Trial of MK-2828 in People With Kidney Disease (MK-2828-006)
End Stage Renal DiseaseRenal ImpairmentChronic Kidney Failure
Merck Sharp & Dohme LLC24 enrolled3 locationsNCT07348237
Recruiting
Phase 1
Safety And Tolerability Of Gamma Glutamylcysteine (GGC) Oral Supplementation In MCI Patients
Mild Cognitive Impairment (MCI)
Pravat Mandal9 enrolled1 locationNCT07583251
Recruiting
Phase 1
A Study to Learn How the Body Processes the Study Medicine PF-07328948 in People With and Without Reduced Liver Function
HealthyHepatic Impairment
Pfizer26 enrolled3 locationsNCT07269301
Recruiting
Phase 1
TREAD: Time Restricted Eating Intervention for Alzheimer's Disease
Alzheimer DiseaseMild Cognitive ImpairmentAlzheimer s Disease
University of California, San Diego60 enrolled1 locationNCT06548191
Recruiting
Phase 1
A Phase I Study to Investigate the Pharmacokinetics and Safety of Capivasertib in Participants With Moderate Hepatic Impairment
Moderate Hepatic Impairment
AstraZeneca20 enrolled2 locationsNCT07343960
Recruiting
Phase 1
A Study to Test How BI 3000202 is Taken up in the Blood of People With and Without Liver Problems
HealthyHepatic Impairment
Boehringer Ingelheim44 enrolled1 locationNCT07486102
Recruiting
Phase 1
A Study to Learn How the Body Processes the Study Medicine PF-07328948 in People With Reduced Kidney Function
HealthyRenal Impairment
Pfizer28 enrolled4 locationsNCT07315360
Recruiting
Phase 1
Radiprodil in Participants With Hepatic Impairment
Hepatic Impairment
GRIN Therapeutics, Inc.40 enrolled2 locationsNCT07457229
Recruiting
Phase 1
Effect of Hepatic Impairment on the Pharmacokinetics of Mirdametinib
HealthyHepatic Impairment
SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany32 enrolled3 locationsNCT06997276
Recruiting
Phase 1Phase 2
A Treatment for a Form of Age-Related Central Auditory Processing Disorder Consisting of Clemastine Fumarate Plus Engineered Sound
Noise-induced hearing lossHearing LossHearing Disorders+22 more
University of Colorado, Denver344 enrolled1 locationNCT07304024
Recruiting
Phase 1
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
DementiaALSMild Cognitive Impairment+2 more
National Institute of Mental Health (NIMH)184 enrolled1 locationNCT04396873
Recruiting
Phase 1
Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease
Cognitive ImpairmentSickle Cell DiseaseAttention Deficit Hyperactivity Disorder (ADHD)+1 more
St. Jude Children's Research Hospital72 enrolled1 locationNCT07226219