Phase 3 Impairment Clinical Trials
15 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–15 of 15 trials
Recruiting
Phase 3
Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy
Visual ImpairmentRadiation Retinopathy
Jaeb Center for Health Research600 enrolled23 locationsNCT05844982
Recruiting
Phase 3
Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour
Cognitive ImpairmentMedulloblastoma, Childhood
Donald Mabbott140 enrolled20 locationsNCT05230758
Recruiting
Phase 3
GLP-1/GCG Dual Agonist in Type 2 Diabetes With Early Dementia (LIGHT-COG Study)
Type 2 DiabetesDementia, MildMild Cognitive Impairment
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School420 enrolled8 locationsNCT07083154
Recruiting
Phase 3
A Study Evaluating the Efficacy of Xanomeline/Trospium (XT) on Cognitive Impairment After 24 and 52 Weeks of Treatment in Adult Participants With Schizophrenia
Cognitive ImpairmentSchizophrenia; Psychosis
European Group for Research In Schizophrenia171 enrolled16 locationsNCT07084831
Recruiting
Phase 3
Evaluate the Use of [18F]-APN-1607 PET in Subjects With AD-related Cognitive Impairment and Subjects With Normal Cognitive Function
Subjects With Mild Cognitive Impairment (MCI) of AD, Alzheimer's Disease (AD) Dementia
JYAMS PET Research & Development Limited316 enrolled2 locationsNCT07422857
Recruiting
Phase 3
Biomarker Exploration in Aging, Cognition and Neurodegeneration
Cognitive ImpairmentCognitive DeclineAlzheimer Disease
University of California, Irvine300 enrolled1 locationNCT03860857
Recruiting
Phase 2Phase 3
MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction
Cognitive ImpairmentMitochondrial AlterationSchizophrenia and Related Disorders
Mclean Hospital100 enrolled3 locationsNCT06191965
Recruiting
Phase 3
Effect of Butyphthalide on Cognitive Level Change After Cerebral Vascular Event-a Randomized Control Trial (Be-CLEVER)
StrokePost-stroke Cognitive Impairment (PSCI)
Fudan University3,200 enrolled1 locationNCT05976152
Completed
Phase 3Phase 4
Effect of prophylactic azithromycin on chest infections in children with neurological and neuromuscular impairment
Neurological impairment
Menzies School of Health Research94 enrolled2 locationsACTRN12621001486819
Terminated
Phase 3
Action To promote brain HEalth iN Adults (ATHENA) trial: a pilot feasibility study to determine the effects of blood pressure lowering treatment provided by a Triple Pill strategy for attenuation of cognitive decline in participants at risk for dementia.
Cognitive ImpairmentCognitive DysfunctionHypertension+1 more
The George Institute for Global Health200 enrolled1 locationACTRN12621000121864
Recruiting
Phase 3
Joint UK and Australia multicentre, randomised, double blind, placebo controlled pragmatic trial comparing 52 weeks of azithromycin to placebo in children with neurological impairment at risk of lower respiratory tract infection (the PARROT trial).
Neurological impairment
University of Liverpool500 enrolled4 locationsACTRN12619001597189
Not Yet Recruiting
Phase 3
Better ways of pain management in adults with hip fractures
Cognitive ImpairmentHip Fracture Pain Management
Townsville Hospital122 enrolled3 locationsACTRN12618001884291
Completed
Phase 3
A Randomised Double-Blind Placebo-Controlled Multicenter Study with Extension to Evaluate the Efficacy Safety and Tolerability of Canagliflozin in the Treatment of Subjects with Type 2 Diabetes Mellitus Who Have Moderate Renal Impairment
Type 2 diabetes in patietns with moderate renal impairment.
Johnson& Johnson Pharmaceutical Research & Development, LLC240 enrolled15 locationsACTRN12610000194066
Recruiting
Phase 3
Vitamin D and Cognition Trial
Mild Cognitive Impairment and vitamin D (25-hydroxyvitamin D) blood concentration between 50 nmol/L and 12.5 nmol/L.
Professor Nicola Lautenschlager110 enrolled1 locationACTRN12607000321448
Recruiting
Phase 3
Preoperative intranenous N-Acetylcysteine for the prevention of renal failure in patients with renal impairment undergoing cardiac surgery
Renal Impairment in cardiac surgery
Prince of Wales Hospital200 enrolled1 locationACTRN12606000088549