Biomarker Exploration in Aging, Cognition and Neurodegeneration

This study is tracking older adults over time using brain scans (MRI and PET), blood tests, and memory assessments to identify early biological markers of Alzheimer's disease and other causes of age-related cognitive decline, with a focus on diverse populations including Spanish speakers. **You may be eligible if...** - You are 60 years old or older - You speak English or Spanish fluently - You have normal cognition (not diagnosed with dementia), with or without subjective memory concerns - You are in generally good health and able to complete all study visits including brain MRI and PET scans - Your vision and hearing are adequate for cognitive testing **You may NOT be eligible if...** - You have a significant neurological disease such as Parkinson's disease, multiple sclerosis, brain tumors, or a history of serious brain injury - You have a serious psychiatric condition such as schizophrenia or bipolar disorder (note: depression and anxiety are NOT exclusionary) - You have been diagnosed with dementia - You have major health conditions that would interfere with the study - You have contraindications to MRI or PET scanning Talk to your doctor to see if this trial is right for you.