Leptomeningeal Metastasis Clinical Trials
0 recruiting
Showing 1–12 of 12 trials
Recruiting
Phase 1
Intrathecal Injection Pemetrexed And Bevacizumab in Patients With Leptomeningeal Metastases in NSCLC
Leptomeningeal MetastasisLung Cancer (NSCLC)
Shanghai Chest Hospital19 enrolled1 locationNCT06663306
Recruiting
Not Applicable
Double-Dose Third-Generation EGFR-TKI Plus Bevacizumab and Intrathecal Chemotherapy for Refractory Leptomeningeal Metastatic NSCLC: A Phase II Study
Leptomeningeal MetastasisLung Neoplasms, Non-Small Cell Lung Cancer
Second Affiliated Hospital of Nanchang University30 enrolled1 locationNCT07398599
Recruiting
Phase 1Phase 2
Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease
HER2-positive Breast CancerLeptomeningeal DiseaseLeptomeningeal Metastasis
H. Lee Moffitt Cancer Center and Research Institute39 enrolled2 locationsNCT04588545
Recruiting
Phase 2
Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib.
Leptomeningeal Metastasis
Guangzhou Medical University36 enrolled1 locationNCT06296745
Recruiting
Phase 4
Intrathecal Chemotherapy Through Ommaya Reservoir Upon Her-2 Negative Breast Cancer With Leptomeningeal Metastasis
HER2-negative Breast CancerLeptomeningeal Metastasis
Fudan University37 enrolled1 locationNCT06230055
Recruiting
Phase 2
Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients With Leptomeningeal Disease
HER2-positive Metastatic Breast CancerLeptomeningeal DiseaseLeptomeningeal Metastasis
UNICANCER30 enrolled11 locationsNCT05800275
Recruiting
Not Applicable
Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer
Leptomeningeal Metastasis
Guangzhou Medical University100 enrolled1 locationNCT06304441
Recruiting
Phase 2
A Study of the Safety and Efficacy of Pemetrexed Combined with Nivolumab Via Intraventricular Injection for the Treatment of Refractory Non-squamous Non-small Cell Lung Cancer with Leptomeningeal Metastases
Leptomeningeal Metastasis
Shanghai Cancer Hospital, China97 enrolled1 locationNCT06901817
Recruiting
Not Applicable
Evaluating High-dose Furmonertinib with Bevacizumab and Pemetrexed for EGFRm NSCLC with Leptomeningeal Metastasis
Non-small Cell Lung CancerLeptomeningeal MetastasisEGFR Gene Mutation
Henan Cancer Hospital60 enrolled2 locationsNCT06643000
Recruiting
Not Applicable
CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer with Leptomeningeal Disease
Leptomeningeal MetastasisEGFR Activating Mutation
British Columbia Cancer Agency10 enrolled1 locationNCT05257967
Recruiting
Phase 1
Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer
NSCLCLeptomeningeal MetastasisLow Dose Radiotherapy+1 more
Sichuan University10 enrolled1 locationNCT06431685
Recruiting
Efficacy and Safety of Intraventricule Pemetrexed Disodium Administered Via Ommaya Reservoir
Lung CancerLeptomeningeal Metastasis
Xiangya Hospital of Central South University64 enrolled1 locationNCT06399926