Intrathecal Chemotherapy Through Ommaya Reservoir Upon Her-2 Negative Breast Cancer With Leptomeningeal Metastasis

This trial is testing a chemotherapy regimen delivered directly into the fluid around the brain and spinal cord (called intrathecal chemotherapy, via an Ommaya reservoir surgically placed under the scalp) for patients with HER2-negative breast cancer that has spread to the lining of the brain (leptomeningeal metastasis). **You may be eligible if...** - You are 18 or older with confirmed HER2-negative metastatic breast cancer - Cancer cells have been found in your cerebrospinal fluid, or imaging and symptoms suggest spread to the brain lining - You have not responded to or cannot tolerate standard treatments - Your ECOG performance status is 3 or less **You may NOT be eligible if...** - Your breast cancer is HER2-positive - You have not yet tried standard treatments - You have uncontrolled infections or other serious medical conditions - Your organ function does not meet the required thresholds Talk to your doctor to see if this trial is right for you.