ClinicalTrialsFinder

Phase 2 Locally Advanced Rectal Cancer Clinical Trials

18 recruitingPhase 2

What is a Phase 2 trial?

Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.

Showing 1–18 of 18 trials

Recruiting
Phase 2

Node-sparing Radiotherapy Combined With Total Neoadjuvant CAPOX and Sintilimab for MSS Middle and Low Rectal Cancer

Locally Advanced Rectal Cancer
Jinhua Central Hospital37 enrolled1 locationNCT06204094
Recruiting
Phase 2

A Single-arm Phase II Clinical Study of Camrelizumab Combined With Long-course Chemoradiotherapy for Total Neoadjuvant Therapy in Locally Advanced Low pMMR/MSS Rectal Cancer

Locally Advanced Rectal Cancer
Chinese PLA General Hospital44 enrolled1 locationNCT07527026
Recruiting
Phase 2

CAPOX and PD-1 Antibody Combined With or Without Radiotherapy for MSS Locally Advanced Rectal Cancer

Neoadjuvant TherapyLocally Advanced Rectal Cancer
Fudan University192 enrolled1 locationNCT06281405
Recruiting
Phase 2

SCRT(Short Course Radiotherapy) Combined With CAPOX Plus QL1706 for Rectal Cancer Liver Metastases

Locally Advanced Rectal Cancer With Liver Metastases
Fujian Cancer Hospital42 enrolled2 locationsNCT06787183
Recruiting
Phase 2

Short-course Radiotherapy Followed by Sequential Chemotherapy With or Without PD-1 Monoclonal Antibody and Bevacizumab as Total Neoadjuvant Therapy in pMMR/MSS Locally Advanced Rectal Cancer （SPARK）

pMMR/MSS Locally Advanced Rectal Cancer
Dechang Diao86 enrolled1 locationNCT07005570
Recruiting
Phase 2

SCRT Combined With Chemotherapy and Iparomlimab and Tuvonralimab in MSS or pMMR Patients With Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer (LARC)
First Affiliated Hospital of Zhejiang University116 enrolled1 locationNCT06864013
Recruiting
Phase 2

A Single-center, Phase II Study on Efficacy & Safety of SCRT+CAPOX+Serplulimab+Bevacizumab for MSS Rectal Cancer

Locally Advanced Rectal Cancer (LARC)
First Affiliated Hospital of Wenzhou Medical University30 enrolled1 locationNCT07347951
Recruiting
Phase 2

Long-course Chemoradiotherapy or Short-course Radiotherapy Combined With CAPOX, PD-1antibody, and COX-2 Inhibitor for MSS Locally Advanced Rectal Cancer (SERRAC)

Neoadjuvant TherapyLocally Advanced Rectal Cancer
Fudan University138 enrolled1 locationNCT07150949
Recruiting
Phase 2

Involved-field Radiotherapy-TNT Combined With PD-1 Inhibitor for pMMR Locally Advanced Rectal Cancer (Neo-Field I)

Locally Advanced Rectal Cancer
Hebei Medical University Fourth Hospital90 enrolled1 locationNCT07057089
Recruiting
Phase 2

Total Neoadjuvant Treatment With or Without Tislelizumab for Locally Advanced Rectal Cancer.

Locally Advanced Rectal Cancer (LARC)
brenner baruch134 enrolled2 locationsNCT06940388
Recruiting
Phase 2

Optimizing Immunotherapy Combined With Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer (LARC)
Cancer Institute and Hospital, Chinese Academy of Medical Sciences228 enrolled2 locationsNCT07040098
Recruiting
Phase 2

MR-guided Adaptive Radiotherapy Combined With PD-1 Antibody and CAPOX for Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer
Fudan University46 enrolled1 locationNCT06840665
Recruiting
Phase 2

Short-course Radiotherapy Followed by AK112 and CAPOX as Neoadjuvant Therapy for Locally Advanced Rectal Cancer

Neoadjuvant TherapyLocally Advanced Rectal Cancer
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology45 enrolled1 locationNCT06802666
Recruiting
Phase 2

Short-course Radiotherapy Followed by Fruquintinib Plus Adebrelimab and CAPOX in the Full Course Neoadjuvant Treatment of Locally Advanced Rectal Cancer: a Multicenter, Single-arm, Open-label Study

Locally Advanced Rectal Cancer
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology45 enrolled1 locationNCT06234007
Recruiting
Phase 2

Neoadjuvant Long-course Chemoradiation Plus PD-1 Blockade for Mid-low Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer
Beijing Friendship Hospital186 enrolled8 locationsNCT05245474
Recruiting
Phase 2

SHR-1701 in Combination With Chemotherapy and Radiotherapy in Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer
Suzhou Suncadia Biopharmaceuticals Co., Ltd.73 enrolled1 locationNCT05300269
Recruiting
Phase 2

Consolidation Versus Induction Chemotherapy in Total Neoadjuvant Therapy of Rectal Cancer With High Risk for Recurrence

Locally Advanced Rectal Cancer
Institute of Oncology Ljubljana62 enrolled1 locationNCT05054959
Completed
Phase 2

Preoperative Radiotherapy and Chemotherapy in patients with locally advanced rectal cancer

Locally Advanced Rectal Cancer
Trans Tasman Radiation Oncology Group (TROG)40 enrolled6 locationsACTRN12610000175077