Phase 1 Male Clinical Trials
44 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 44 trials
Recruiting
Phase 1
Single-ascending Dose Study of HEC-151 Injection
Healthy Adult Male
Sunshine Lake Pharma Co., Ltd.81 enrolled2 locationsNCT07376200
Recruiting
Phase 1Phase 2
Open-Label Study of Pocenbrodib Alone and in Combination With Abiraterone Acetate, Olaparib, or 177Lu-PSMA-617
Prostate CancerNeoplasmsNeoplasms by Site+7 more
Pathos AI, Inc.252 enrolled18 locationsNCT06785636
Recruiting
Phase 1
A Study to Evaluate the Effect of Food on the Bioavailability of AJ201, and Safety, Tolerability, and Pharmacokinetics of AJ201 in Japanese and White Healthy Male Participants
Food Effect in Healthy VolunteersHealthy Male Adults
AnnJi Pharmaceutical Co., Ltd.26 enrolled1 locationNCT07549919
Recruiting
Phase 1
A Study of ORN252 in Healthy Participants
Healthy Volunteers - Male and Female
Orna Therapeutics, Inc.20 enrolled1 locationNCT07439796
Recruiting
Phase 1Phase 2
Gedatolisib in Combination With Darolutamide in Metastatic Castration-Resistant Prostate Cancer
Prostate CancermCRPC (Metastatic Castration-resistant Prostate Cancer)Prostatic Neoplasms, Castration-Resistant+3 more
Celcuity Inc54 enrolled13 locationsNCT06190899
Recruiting
Phase 1Phase 2
ERADICATE: A Phase Ib/II Study of Elacestrant Plus Trastuzumab Deruxtecan in Patients With CDK4/6 Inhibitor and Endocrine-resistant HR+/HER2-low or HER2-ultralow Metastatic Breast Cancer
Breast CancerMetastatic Breast CancerBreast Cancer Female+2 more
Sarah Sammons, MD65 enrolled1 locationNCT07198724
Recruiting
Phase 1
A Phase 1 Comparative Study to Evaluate Pharmacokinetics, Immunogenicity, Safety and Tolerability of Bmab3000 and Herceptin Hylecta® After a Single 600 mg SC Injection in Healthy Male Volunteers
Healthy Male Participants
Biocon Biologics UK PLC150 enrolled1 locationNCT07299955
Recruiting
Phase 1
A Study to Evaluate the Safety of Increasing Doses of DF5112 in Healthy Adults
HealthyHealthy ParticipantsHealthy Adult Male+2 more
Dragonfly Therapeutics48 enrolled1 locationNCT07232121
Recruiting
Phase 1
MUC1-Activated T Cells for the Treatment of Relapsed and Resistant Ovarian Cancer
Recurrent Ovarian CarcinomaRecurrent Fallopian Tube CarcinomaRecurrent Primary Peritoneal Carcinoma+13 more
Mayo Clinic12 enrolled1 locationNCT06483048
Recruiting
Phase 1
A Drug-drug Interaction Study of Vorasidenib and a Combined Oral Contraceptive in Healthy Female Participants
Healthy Adult Female Participants
Institut de Recherches Internationales Servier (I.R.I.S.)28 enrolled1 locationNCT07235774
Recruiting
Phase 1
Talazoparib and Radiation Therapy in Treating Patients With Locally Recurrent Gynecologic Cancers
Malignant Female Reproductive System NeoplasmStage IV Cervical Cancer AJCC v8Stage IVA Cervical Cancer AJCC v8+22 more
M.D. Anderson Cancer Center24 enrolled2 locationsNCT03968406
Recruiting
Phase 1
Pharmacokinetic Comparison of Vonafexor Acid and Its Lysine Salt and Evaluation of Potential Drug-Drug Interactions
Healthy Adult Male and Female Volunteers
Enyo Pharma40 enrolled1 locationNCT07251153
Recruiting
Phase 1
A Study of ORX489 in Healthy Adult Participants, Aged 18 to 60 Years
Healthy Adult Male and Female Volunteers
Centessa Pharmaceuticals (UK) Limited212 enrolled1 locationNCT07413666
Recruiting
Phase 1Phase 2
Open Label, Dose Escalation, Repeat Dose Study Evaluating YCT-529 in Healthy Males
Male Contraception
YourChoice Therapeutics, Inc.88 enrolled1 locationNCT06542237
Recruiting
Phase 1
A Study of TJ101 Injection Before and After CMC Change Following Subcutaneous Injection in Healthy Adult Male Subjects in China
Healthy Adult Males in China
TJ Biopharma Co., Ltd.96 enrolled1 locationNCT07300436
Recruiting
Phase 1
A Comparative Bioavailability Study of Two Torasemide 10 mg Tablets Formulations in Healthy Adult Participants Under Fasting Conditions:
Healthy Adult Male and Female Volunteers
Berlin-Chemie AG Menarini Group26 enrolled1 locationNCT07201584
Recruiting
Phase 1
Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax
Malignant Solid NeoplasmAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8+71 more
M.D. Anderson Cancer Center43 enrolled1 locationNCT05092373
Recruiting
Phase 1
A Study to Assess the Pharmacokinetics of GEn-1124 After Single Oral Dosing in Healthy Subjects
Healthy Adult Male
GEn1E Lifesciences6 enrolled1 locationNCT07185113
Recruiting
Phase 1
Comparative Study of EnliTuo® Before and After Technology Change in Healthy Male Volunteers
Healthy Adult Male
Taizhou Mabtech Pharmaceutical Co.,Ltd86 enrolled1 locationNCT07246291
Recruiting
Phase 1
Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases
Malignant Neoplasm of Bone and Articular CartilageMalignant Neoplasms of Female Genital OrgansMalignant Neoplasms of Independent (Primary) Multiple Sites+7 more
M.D. Anderson Cancer Center44 enrolled1 locationNCT03093909