Phase 1 Male Clinical Trials
48 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 48 trials
Recruiting
Phase 1
A Study to Understand What the Body Does to the Study Medicine Called PF-07799544 When Taken by Healthy Adults
Healthy male volunteers
Pfizer9 enrolled1 locationNCT07578636
Recruiting
Phase 1Phase 2
ERADICATE: A Phase Ib/II Study of Elacestrant Plus Trastuzumab Deruxtecan in Patients With CDK4/6 Inhibitor and Endocrine-resistant HR+/HER2-low or HER2-ultralow Metastatic Breast Cancer
Breast CancerMetastatic Breast CancerBreast Cancer Female+2 more
Kristina A. Fanucci65 enrolled1 locationNCT07198724
Recruiting
Phase 1
Safety and Feasibility Study of Autologous Engineered Urethral Constructs for the Treatment of Strictures
Male Urogenital DiseasesUrologic DiseasesUrethral Stricture+1 more
Wake Forest University Health Sciences10 enrolled2 locationsNCT03258658
Recruiting
Phase 1Phase 2
Study of ABS-201 Evaluating Single and Multiple Ascending Doses in Healthy Adults With and Without Androgenetic Alopecia
Androgenetic alopecia (AGA)Healthy Volunteers - Male and Female
Absci Pty Ltd.227 enrolled4 locationsNCT07317544
Recruiting
Phase 1
Study of Aerosol Gemcitabine in Patients With Solid Tumors and Pulmonary Metastases
Malignant Neoplasm of Bone and Articular CartilageMalignant Neoplasms of Female Genital OrgansMalignant Neoplasms of Independent (Primary) Multiple Sites+7 more
M.D. Anderson Cancer Center44 enrolled1 locationNCT03093909
Recruiting
Phase 1
Safety and PK Study of BICX104 With or Without Bupropion Compared to Vivitrol
Healthy Adult Male and Female Volunteers
BioCorRx Pharmaceuticals Inc30 enrolled1 locationNCT07269873
Recruiting
Phase 1
Single-ascending Dose Study of HEC-151 Injection
Healthy Adult Male
Sunshine Lake Pharma Co., Ltd.81 enrolled2 locationsNCT07376200
Recruiting
Phase 1
A Study to Evaluate the Effect of Food on the Bioavailability of AJ201, and Safety, Tolerability, and Pharmacokinetics of AJ201 in Japanese and White Healthy Male Participants
Food Effect in Healthy VolunteersHealthy Male Adults
AnnJi Pharmaceutical Co., Ltd.26 enrolled1 locationNCT07549919
Recruiting
Phase 1
A Study of ORN252 in Healthy Participants
Healthy Volunteers - Male and Female
Orna Therapeutics, Inc.20 enrolled1 locationNCT07439796
Recruiting
Phase 1
Study to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]GRT6019
Healthy male volunteers
Grünenthal GmbH10 enrolled1 locationNCT07479745
Recruiting
Phase 1Phase 2
Gedatolisib in Combination With Darolutamide in Metastatic Castration-Resistant Prostate Cancer
Prostate CancermCRPC (Metastatic Castration-resistant Prostate Cancer)Prostatic Neoplasms, Castration-Resistant+3 more
Celcuity Inc54 enrolled13 locationsNCT06190899
Recruiting
Phase 1
A Phase 1 Comparative Study to Evaluate Pharmacokinetics, Immunogenicity, Safety and Tolerability of Bmab3000 and Herceptin Hylecta® After a Single 600 mg SC Injection in Healthy Male Volunteers
Healthy Male Participants
Biocon Biologics UK PLC150 enrolled1 locationNCT07299955
Recruiting
Phase 1
A Study to Evaluate the Safety of Increasing Doses of DF5112 in Healthy Adults
HealthyHealthy ParticipantsHealthy Adult Male+2 more
Dragonfly Therapeutics48 enrolled1 locationNCT07232121
Recruiting
Phase 1
MUC1-Activated T Cells for the Treatment of Relapsed and Resistant Ovarian Cancer
Recurrent Ovarian CarcinomaRecurrent Fallopian Tube CarcinomaRecurrent Primary Peritoneal Carcinoma+13 more
Mayo Clinic12 enrolled1 locationNCT06483048
Recruiting
Phase 1
A Drug-drug Interaction Study of Vorasidenib and a Combined Oral Contraceptive in Healthy Female Participants
Healthy Adult Female Participants
Institut de Recherches Internationales Servier (I.R.I.S.)28 enrolled1 locationNCT07235774
Recruiting
Phase 1
Talazoparib and Radiation Therapy in Treating Patients With Locally Recurrent Gynecologic Cancers
Malignant Female Reproductive System NeoplasmStage IV Cervical Cancer AJCC v8Stage IVA Cervical Cancer AJCC v8+22 more
M.D. Anderson Cancer Center24 enrolled2 locationsNCT03968406
Recruiting
Phase 1
Pharmacokinetic Comparison of Vonafexor Acid and Its Lysine Salt and Evaluation of Potential Drug-Drug Interactions
Healthy Adult Male and Female Volunteers
Enyo Pharma40 enrolled1 locationNCT07251153
Recruiting
Phase 1
A Study of ORX489 in Healthy Adult Participants, Aged 18 to 60 Years
Healthy Adult Male and Female Volunteers
Centessa Pharmaceuticals (UK) Limited212 enrolled1 locationNCT07413666
Recruiting
Phase 1Phase 2
Open Label, Dose Escalation, Repeat Dose Study Evaluating YCT-529 in Healthy Males
Male Contraception
YourChoice Therapeutics, Inc.88 enrolled1 locationNCT06542237
Recruiting
Phase 1
A Study of TJ101 Injection Before and After CMC Change Following Subcutaneous Injection in Healthy Adult Male Subjects in China
Healthy Adult Males in China
TJ Biopharma Co., Ltd.96 enrolled1 locationNCT07300436