Male Clinical Trials

398 recruitingLast updated: June 18, 2026

There are 398 actively recruiting male clinical trials across 66 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4, Early Phase 1. Top locations include Boston, Massachusetts, United States, Houston, Texas, United States, San Francisco, California, United States. Updated daily from ClinicalTrials.gov.


Male Trials at a Glance

398 actively recruiting trials for male are listed on ClinicalTrialsFinder across 6 cities in 66 countries. The largest study group is Not Applicable with 173 trials, with the heaviest enrollment activity in Boston, Houston, and San Francisco. Lead sponsors running male studies include ART Fertility Clinics LLC, Mayo Clinic, and Fondazione Policlinico Universitario Agostino Gemelli IRCCS.

Treatments under study

About Male Clinical Trials

Looking for clinical trials for Male? There are currently 4 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Male trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Male clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 398 trials

Recruiting
Phase 2

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

Malignant Solid NeoplasmMalignant Female Reproductive System NeoplasmRecurrent Malignant Solid Neoplasm+1 more
National Cancer Institute (NCI)70 enrolled187 locationsNCT06126276
Recruiting
Phase 2

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Malignant Female Reproductive System Neoplasm+12 more
National Cancer Institute (NCI)2,900 enrolled479 locationsNCT05564377
Recruiting
Phase 4

Neoadjuvant Weekly Paclitaxel and Biomarkers of Therapy Response

Breast Neoplasm Female
University of Wisconsin, Madison50 enrolled2 locationsNCT03096418
Recruiting
Phase 3

A Randomized Trial of Five Fraction Partial Breast Irradiation (RAPID2)

Breast Neoplasm FemaleRadiotherapyCosmetic Outcome
Ontario Clinical Oncology Group (OCOG)910 enrolled29 locationsNCT05417516
Recruiting

PROspective Study of Mothers' and Infants' Social and Epidemiologic Determinants of Health

Infertility, Female
Northwestern University1,000 enrolled1 locationNCT05358483
Recruiting

Natural History Study of Patients With Excess Androgen

Congenital Adrenal Hyperplasia (CAH)Familial Male-Limited Precocious Puberty (FMPP)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)3,000 enrolled2 locationsNCT00250159
Recruiting
Not Applicable

Single Infrapubic Versus Bilateral Subinguinal Microsurgical Varicocelectomy

Male infertilityBilateral Varicocele
Beni-Suef University40 enrolled1 locationNCT07650955
Recruiting
Phase 1

A Study to Understand What the Body Does to the Study Medicine Called PF-07799544 When Taken by Healthy Adults

Healthy male volunteers
Pfizer9 enrolled1 locationNCT07578636
Recruiting

Development of an AI Platform for the Analysis of Sperm and Prediction of Their Clinical Potential

Male infertilityInfertility (IVF Patients)Reproductive Issues+2 more
Fecundis Lab SL500 enrolled5 locationsNCT07456397
Recruiting
Phase 2

18F FES-PET/MRI for Tailoring Treatment of Luminal A and Lobular Breast Cancer

Breast Cancer FemaleLobular Breast CarcinomaPET/MRI+2 more
Università Vita-Salute San Raffaele119 enrolled1 locationNCT05982496
Recruiting
Phase 1Phase 2

ERADICATE: A Phase Ib/II Study of Elacestrant Plus Trastuzumab Deruxtecan in Patients With CDK4/6 Inhibitor and Endocrine-resistant HR+/HER2-low or HER2-ultralow Metastatic Breast Cancer

Breast CancerMetastatic Breast CancerBreast Cancer Female+2 more
Kristina A. Fanucci65 enrolled1 locationNCT07198724
Recruiting
Phase 2

Early Oxybutinin Treatment for Boys With Posterior Urethral Valves

Male Urogenital Diseases
University Hospital, Bordeaux50 enrolled1 locationNCT04526353
Recruiting

Biorepository in Participants Who Undergo OTC for Gonadotoxic Therapy

InfertilityAcute Ovarian FailureEarly Menopause And Infertility In Females After Treatment For Childhood Cancer
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)100 enrolled1 locationNCT05440617
Recruiting
Phase 1

Safety and Feasibility Study of Autologous Engineered Urethral Constructs for the Treatment of Strictures

Male Urogenital DiseasesUrologic DiseasesUrethral Stricture+1 more
Wake Forest University Health Sciences10 enrolled2 locationsNCT03258658
Recruiting
Phase 3

Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty

Urethral Stricture, Male
University of California, San Francisco60 enrolled2 locationsNCT05300685
Recruiting
Not Applicable

Interaction Between Inorganic Nitrate Supplementation and Metformin in Individuals With Prediabetes

PrediabetesMetforminsedentary+2 more
University of Virginia24 enrolled1 locationNCT07131384
Recruiting
Phase 4

Evaluation of a Long Versus Short Clomid Protocol for Controlled Ovarian Stimulation

Infertility, Female
University of Southern California120 enrolled1 locationNCT06701071
Recruiting

Male Infertility and Assisted Reproductive Technologies Research Biobank

Male infertilityInfertility (IVF Patients)
Reproductive Medicine Associates of New Jersey1,000 enrolled1 locationNCT06880302
Recruiting

Assessment of Female Sexual Function Index (FSFI) Scores at 1 Month After Endometrial Sampling Performed Under Sedo-Analgesia or Local Anesthesia

Female Sexual DysfunctionEndometrial SamplingFemale Sexual Function Index (FSFI)+1 more
Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization210 enrolled1 locationNCT07628660
Recruiting
Phase 4

Opioid Use After Laparoscopic Salpingectomy

Opioid UsePost Operative PainSterility, Female
Johns Hopkins University38 enrolled1 locationNCT06434233