Phase 1 Medicine Clinical Trials
20 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 20 trials
Recruiting
Phase 1Phase 2
Mindfulness Meditation for Insomnia
InsomniaMindfulnessTelemedicine+2 more
Brigham and Women's Hospital30 enrolled1 locationNCT06972303
Recruiting
Phase 1
Clinical Investigation of Herbal Formulation and Its Efficacy in Polycystic Ovarian Syndrome
InfertilityPolycystic Ovarian Syndrome (PCOS)Herbal Medicine+1 more
Jinnah Postgraduate Medical Centre116 enrolled1 locationNCT07399535
Recruiting
Phase 1Phase 2
Study of Pazopanib Combined With Palbociclib for Refractory Solid Tumors With Co-amplified in the 11q13(FGF3/4/19/CCND1)
Solid Tumor, AdultPrecision MedicineNext-generation Sequencing
Tianjin Medical University Second Hospital65 enrolled1 locationNCT06895733
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of 5/2.5 mg s 4,5a-epoxy14-hydroxy-3-methoxy-17-methylmorphinan-6-one hydrochloride/naloxone tablet against the innovator 5/2.5 mg s 4,5a-epoxy14-hydroxy-3-methoxy-17-methylmorphinan-6-one hydrochloride/naloxone tablet conducted under fasting conditions in healthy volunteers.
5/2.5 mg s 4,5a-epoxy14-hydroxy-3-methoxy-17-methylmorphinan-6-one hydrochloride/naloxone belongs to a class of medicines called opioid analgesics and is prescribed for the relief of severe pain.
Zenith Technology Corporation Limited26 enrolled1 locationACTRN12620000327987
Completed
Phase 1
Comparative assessment of the absorption of a test formulation of 1 x 40 mg isotretinoin capsule against the innovator 1 x 40 mg isotretinoin capsule conducted under fed conditions in healthy male volunteers.
Isotretinoin is a medicine that is used to treat severe forms of acne.
Zenith Technology Corp Ltd40 enrolled1 locationACTRN12619000154101
Completed
Phase 1
Comparative assessment of the absorption of a test formulation of 1 x 40 mg isotretinoin capsule against the innovator 1 x 40 mg isotretinoin capsule conducted under fasting conditions in healthy male volunteers.
Isotretinoin is a medicine that is used to treat severe forms of acne.
Zenith Technology Corp Ltd38 enrolled1 locationACTRN12618001804279
Completed
Phase 1
A Multicentre, Randomised, Controlled, Observer-Blind Study to Evaluate Safety and Duration in Stomach of Modified Release Prototype Capsules in Healthy Adults
Non-adherence to medicines
Lyndra Australia Pty Ltd.40 enrolled1 locationACTRN12618000991213
Completed
Phase 1
Comparative assessment of the absorption of a test formulation of 1 x 30 mg isotretinoin capsule against the innovator 1 x 30 mg isotretinoin capsule conducted under fed conditions in healthy male volunteers.
Isotretinoin is a medicine that is used to treat severe forms of acne.
Zenith Technology Corporation Limited40 enrolled1 locationACTRN12618000935235
Completed
Phase 1
Comparative assessment of the absorption of a test formulation of 1 x 10 mg alitretinoin capsule against the innovator 1 x 10 mg alitretinoin capsule conducted under fed conditions in healthy male volunteers.
Bioequivalence study conducted in healthy volunteers comparing a formulation of alitretinoin with no health condition or problem studied.
Although this study is being conducted in healthy volunteers who are not being treated for the condition to which the medicine is used, alitretinoin is a medicine that is used to treat severe chronic eczema that is unresponsive to treatment with potent topical corticosteroids.
Zenith Technology Corp Ltd30 enrolled1 locationACTRN12618000247279
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of ferrous sulfate/sodium ascorbate modified release tablet against the innovator ferrous sulfate/sodium ascorbate modified release tablet conducted under fasting conditions with diet control in healthy male volunteers
Iron deficiency.
Although this study is being conducted in healthy volunteers who are not being treated for the condition to which the medicine is used, ferrous sulfate and vitamin C is an iron supplement indicated for the prevention and treatment of iron deficiency.
Zenith Technology Corp Ltd24 enrolled1 locationACTRN12618000222246
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of atorvastatin oral spray against the innovator atorvastatin capsule conducted under fasting conditions in healthy male and female volunteers
Pilot pharmacokinetic study conducted in healthy volunteers comparing two formulations of atorvastatin (oral spray and capsule) with no health condition or problem studied.
Although this study is being conducted in healthy volunteers who are not being treated for the condition to which the medicine is used, atorvastatin is used as an adjunct to diet for the treatment of patients with hypercholesterolaemia.
Zenith Technology Corp Ltd10 enrolled1 locationACTRN12618000208202
Completed
Phase 1
Comparative assessment of the absorption of a test formulation of 1 x 30 mg isotretinoin capsule against the innovator 1 x 30 mg isotretinoin capsules conducted under fasting conditions in healthy male volunteers.
Isotretinoin is a medicine that is used to treat severe forms of acne.
Zenith Technology Corp Ltd36 enrolled1 locationACTRN12617001407381
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of phentermine capsule against the innovator phentermine capsule conducted under fed conditions in healthy male and female volunteers in a pilot study
Bioequivalence pilot study conducted in healthy volunteers comparing two formulations of phentermine with no health condition or problem studied.
Although this study is being conducted in healthy volunteers who are not being treated for the condition to which the medicine is used, phentermine is a C5 Controlled Drug indicated in the management of obesity as a short-term adjunct in a medically monitored comprehensive regime of weight reduction.
Zenith Technology Corp Ltd10 enrolled1 locationACTRN12617000172303
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of voriconazole suspension against the innovator voriconazole suspension conducted under fasting conditions in healthy male and female volunteers
Bioequivalence study conducted in healthy volunteers comparing two formulations of voriconazole with no health condition or problem studied.
Although this study is being conducted in healthy volunteers who are not being treated for the condition to which the medicine is used, voriconazole is a triazole antifungal agent that is used to treat fungal and yeast infections.
Zenith Technology Corporation Limited24 enrolled1 locationACTRN12616001650482
Completed
Phase 1
Comparative assessment of the absorption of a test formulation of 1 x 30 mg alitretinoin capsule against the innovator 1 x 30 mg alitretinoin capsule conducted under fed conditions in healthy male volunteers.
Bioequivalence study conducted in healthy volunteers comparing a formulation of alitretinoin with no health condition or problem studied.
Although this study is being conducted in healthy volunteers who are not being treated for the condition to which the medicine is used, alitretinoin is a medicine that is used to treat severe chronic eczema that is unresponsive to treatment with potent topical corticosteroids.
Zenith Technology Corp Ltd30 enrolled1 locationACTRN12616001221448
Completed
Phase 1
Comparative assessment of the absorption of a generic formulation of Inhaled Insulin against the innovators Humalog KwikPen for injection and the AFREZZA Inhalation Powder Cartridge conducted under fasting conditions in healthy male and female volunteers
Pharmacokinetic and pharmacodynamic study conducted in healthy volunteers comparing three formulations of Insulin with no health condition or problem studied.
Insulin is a medicine that is used to lower blood glucose.
Zenith Technology Corp Ltd18 enrolled1 locationACTRN12615001100583
Completed
Phase 1
Comparative assessment in healthy male volunteers under fasting conditions of the absorption and pharmacokinetics of 3 generic formulations of isotretinoin capsules against the innovator isotretinoin capsule in a pilot study
Pilot study conducted in healthy volunteers comparing four formulations of isotretinoin with no health condition or problem studied.
Although this study is being conducted in healthy volunteers who are not being treated for the condition to which the medicine is used, isotretinoin is a medicine that is used to treat severe forms of acne.
Zenith Technology Corp Ltd16 enrolled1 locationACTRN12615001083583
Completed
Phase 1
Comparative assessment of the absorption of 3 generic formulations of isotretinoin capsules against the innovator isotretinoin capsule in a pilot study conducted under fasting conditions in healthy male volunteers
Pilot study conducted in healthy volunteers comparing four formulations of isotretinoin with no health condition or problem studied.
Although this study is being conducted in healthy volunteers who are not being treated for the condition to which the medicine is used, isotretinoin is a medicine that is used to treat severe forms of acne.
Zenith Technology Corp Ltd16 enrolled1 locationACTRN12615000569505
Completed
Phase 1
A single dose, randomized, blinded, pilot, comparative assessment of the absorption of a generic formulation of tibolone tablet against the innovator tibolone tablet conducted in healthy female volunteers under fasting conditions
Pilot bioequivalence study conducted in healthy volunteers comparing two formulations of tibolone with no health condition or problem studied.
Although this study is being conducted in healthy volunteers who are not being treated for the condition to which the medicine is used, tibolone belongs to a class of medicines called synthetic steroid hormone drugs and is prescribed for the short-term treatment of symptoms due to natural or surgical menopause.
Zenith Technology Corporation Limited8 enrolled1 locationACTRN12613000943741
Completed
Phase 1
Interactions between herbal medicines and the anticoagulant warfarin
Drug interactions of warfarin with herbal medicines in healthy male subjects. Relevant to Stroke prevention and people receiving warfarin
Prof Andrew McLachlan60 enrolled1 locationACTRN12607000054415